2. Membrane Transporter/Ion Channel Cell Cycle/DNA Damage
  3. P2X Receptor Nucleoside Antimetabolite/Analog
  4. MRS2339

MRS2339 is a ribose-modified nucleotide and a nucleotidase-resistant P2 receptor agonist. MRS2339 activates P2X4R. MRS2339 induces ionic currents via P2X receptors, reduces cardiomyocyte cross-sectional area and heart weight/body weight ratio, lacks vasodilatory activity, and extends the lifespan of mice with cardiomyopathy. MRS2339 can be used in research related to heart failure and cardiomyopathy.

For research use only. We do not sell to patients.

MRS2339

MRS2339 Chemical Structure

CAS No. : 436847-13-1

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MRS2339 Related Antibodies

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Description

MRS2339 is a ribose-modified nucleotide and a nucleotidase-resistant P2 receptor agonist. MRS2339 activates P2X4R. MRS2339 induces ionic currents via P2X receptors, reduces cardiomyocyte cross-sectional area and heart weight/body weight ratio, lacks vasodilatory activity, and extends the lifespan of mice with cardiomyopathy. MRS2339 can be used in research related to heart failure and cardiomyopathy[1][2].

IC50 & Target[1]

P2X4 Receptor

 

In Vitro

MRS2339 (10 μM) induces a P2X-like ionic current with identical voltage dependence and reversal potential to 2-meSATP in isolated wild-type and CSQ mouse ventricular cardiac myocytes[1].
MRS2339 (10-9-10-5 M) shows no vasodilator effect in isolated wild-type mouse thoracic aorta ring preparations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MRS2339 Related Antibodies
In Vivo

MRS2339 (delivered via mini-osmotic pump; approximately 6 μl/day; for 28 days) significantly extends the median lifespan of CSQ mice, a heart failure model, reduces the cross-sectional area of cardiomyocytes, and decreases the ratio of heart weight to body weight[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: calsequestrin (CSQ) transgenic (TG) mice (either sex, ~3 months old)[1]
Dosage: 3 μM
Administration: miniosmotic pump; ~6 μl/day; 28 days
Result: Increased median lifespan to 115 days (log rank test, P = 0.02) compared to vehicle controls.
Reduced cardiac myocyte cross-sectional area to 281 μm2 (n = 6 mice, P < 0.05 vs.
vehicle).
Reduced heart weight-to-body weight ratio to 10.5 mg/gram (n = 9 hearts, P < 0.05 vs.
vehicle).
Molecular Weight

391.70

Formula

C12H15ClN5O6P
CAS No.
SMILES

OP(OC[C@]12[C@H]([C@@H](O)[C@H](N3C4=NC(Cl)=NC(N)=C4N=C3)[C@H]1C2)O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MRS2339 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRS2339436847-13-1MRS 2339MRS-2339P2X ReceptorNucleoside Antimetabolite/AnalogP2XRscardiomyopathic miceheart failurecardiac hypertrophycardiomyopathycardiac myocyteswild-type mouse thoracic aorta ring preparationsCSQ miceP2X4 receptorsCSQ mouse ventricular cardiac myocytesP2X receptorsInhibitorinhibitorinhibit

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