436847-13-1
Chemical Structure
MRS2339
- CAS No.: 436847-13-1
- Formula:C12H15ClN5O6P
- Molecular Weight:391.70
InChIKey: FTSUGKZNIRUKKK-OBPILZPTSA-N
SMILES: OP(OC[C@]12[C@H]([C@@H](O)[C@H](N3C4=NC(Cl)=NC(N)=C4N=C3)[C@H]1C2)O)(O)=O
Biological Activity: MRS2339 is a ribose-modified nucleotide and a nucleotidase-resistant P2 receptor agonist. MRS2339 activates P2X4R. MRS2339 induces ionic currents via P2X receptors, reduces cardiomyocyte cross-sectional area and heart weight/body weight ratio, lacks vasodilatory activity, and extends the lifespan of mice with cardiomyopathy. MRS2339 can be used in research related to heart failure and cardiomyopathy[1][2].
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MRS2339 | MRS2339 is a ribose-modified nucleotide and a nucleotidase-resistant P2 receptor agonist. MRS2339 activates P2X4R. MRS2339 induces ionic currents via P2X receptors, reduces cardiomyocyte cross-sectional area and heart weight/body weight ratio, lacks vasodilatory activity, and extends the lifespan of mice with cardiomyopathy. MRS2339 can be used in research related to heart failure and cardiomyopathy. | |||||||||||||||||||||
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- [1]. Shen JB, et al. P2X purinergic receptor-mediated ionic current in cardiac myocytes of calsequestrin model of cardiomyopathy: implications for the treatment of heart failure. Am J Physiol Heart Circ Physiol. 2007;292(2):H1077-H1084. [Content Brief]
- [2]. Shen JB, et al. Prevention and rescue of cardiac dysfunction by methanocarba adenosine monophosphonate derivatives. Purinergic Signal. 2020;16(1):61-72. [Content Brief]
Keywords
