2. Protein Tyrosine Kinase/RTK
  3. FAK
  4. NVP-TAC544

NVP-TAC544 is a focal adhesion kinase (FAK) inhibitor. NVP-TAC544 inhibits angiogenesis. NVP-TAC544 can be used for the research of melanoma (primary or metastatic).

For research use only. We do not sell to patients.

NVP-TAC544

NVP-TAC544 Chemical Structure

CAS No. : 761436-62-8

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NVP-TAC544 Related Antibodies

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Description

NVP-TAC544 is a focal adhesion kinase (FAK) inhibitor. NVP-TAC544 inhibits angiogenesis. NVP-TAC544 can be used for the research of melanoma (primary or metastatic)[1][2].

In Vitro

NVP-TAC544 (0.1-2.5 μM; 1 h) dose-dependently inhibits FAK pY397 phosphorylation and increases Pyk2 pY402 phosphorylation in bovine aortic endothelial cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NVP-TAC544 Related Antibodies

Western Blot Analysis[1]

Cell Line: bovine aortic endothelial cells (BAECs)
Concentration: 0.1 μM; 0.25 μM; 0.5 μM; 1 μM; 2.5 μM
Incubation Time: 1 h
Result: Induced a dose-dependent decrease in FAK pY397 phosphorylation, with near-complete inhibition observed at concentrations ≥0.25 μM.
Induced a dose-dependent increase in Pyk2 pY402 phosphorylation, with peak activation (~2.5-fold increase versus DMSO control) observed at 0.25-1 μM.
In Vivo

NVP-TAC544 (40 mg/kg; i.p.; daily) produces an 80% reduction in bFGF-induced angiogenesis in wild-type C57BL/6 mice but fails to inhibit angiogenesis in i-EC-FAK-KO mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (age-matched littermates; wild-type and inducible endothelial cell-specific FAK knockout (i-EC-FAK-KO) genotypes)[1]
Dosage: 40 mg/kg
Administration: i.p.; daily
Result: Reduced bFGF-mediated angiogenesis by 80% in wild-type mice (P < 0.05).
Exerted no effect on bFGF-mediated angiogenesis in i-EC-FAK-KO mice.
Molecular Weight

549.44

Formula

C22H25BrN6O4S
CAS No.
SMILES

O=S(NC)(C1=C(NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2Br)C=CC=C1)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NVP-TAC544 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NVP-TAC544761436-62-8FAKPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinasebasic fibroblast growth factorbovine aortic endothelial cellsfocal adhesion kinaseinducible endothelial cell-specific FAK knockout micePyk2endothelial cellsuveal melanoma cellsYAPwild-type miceInhibitorinhibitorinhibit

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