NVP-TAC544
NVP-TAC544 is a focal adhesion kinase (FAK) inhibitor. NVP-TAC544 inhibits angiogenesis. NVP-TAC544 can be used for the research of melanoma (primary or metastatic).
For research use only. We do not sell to patients.
- CAS No.: 761436-62-8
- Formula: C22H25BrN6O4S
- Molecular Weight:549.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
NVP-TAC544 (0.1-2.5 μM; 1 h) dose-dependently inhibits FAK pY397 phosphorylation and increases Pyk2 pY402 phosphorylation in bovine aortic endothelial cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:bovine aortic endothelial cells (BAECs)
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Concentration:0.1 μM; 0.25 μM; 0.5 μM; 1 μM; 2.5 μM
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Incubation Time:1 h
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Result:Induced a dose-dependent decrease in FAK pY397 phosphorylation, with near-complete inhibition observed at concentrations ≥0.25 μM.
Induced a dose-dependent increase in Pyk2 pY402 phosphorylation, with peak activation (~2.5-fold increase versus DMSO control) observed at 0.25-1 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (age-matched littermates; wild-type and inducible endothelial cell-specific FAK knockout (i-EC-FAK-KO) genotypes)[1]
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Dosage:40 mg/kg
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Administration:i.p.; daily
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Result:Reduced bFGF-mediated angiogenesis by 80% in wild-type mice (P < 0.05).
Exerted no effect on bFGF-mediated angiogenesis in i-EC-FAK-KO mice.
Chemical Information
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CAS No. 761436-62-8
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Molecular Weight 549.44
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Formula C22H25BrN6O4S
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SMILES
O=S(NC)(C1=C(NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2Br)C=CC=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Weis SM, et al. Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. J Cell Biol. 2008;181(1):43-50. [Content Brief]
[2]. Chuang HH, et al. FAK in Cancer: From Mechanisms to Therapeutic Strategies. Int J Mol Sci. 2022;23(3):1726. Published 2022 Feb 2. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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