Olanexidine 

Olanexidine is an antibacterial agent. Olanexidine is active against a wide range of bacteria, imcluding both Gram-positive and Gram-negative bacteria Olanexidine is also an antiseptic. Olanexidine can be used in the research of infection and inflammation^[1][2][3].

Olanexidine (50 μM, 48 h) exhibits broad-spectrum bactericidal activity against Gram-positive cocci and Gram-negative bacteria^[1].
Olanexidine (50 μg/mL, 24 h) inhibits chronic inflammatory reactions in oral mucosal cells^[2].
Olanexidine (Olanexidine gluconate, 0-15000 μg/mL) inhibits the binding ability of virus-like particles to the binding receptor of human norovirus and increases the aggregation of virus-like particles^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Olanexidine (1 -2% in saline, applied to the skin) is active against transient or resident bacterial flora on the skin of male cynomolgus monkeys^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

372.34

C₁₇H₂₇Cl₂N₅

146510-36-3

N=C(NCC1=CC=C(Cl)C(Cl)=C1)NC(NCCCCCCCC)=N

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hagi A, et al. Bactericidal Effects and Mechanism of Action of Olanexidine Gluconate, a New Antiseptic. Antimicrob Agents Chemother. 2015 Aug;59(8):4551-9.  [Content Brief]

  [2]. Nii T, Yumoto H, Hirota K, Miyake Y. Anti-inflammatory effects of olanexidine gluconate on oral epithelial cells. BMC Oral Health. 2019 Nov 8;19(1):239.  [Content Brief]

  [3]. Imai K, et al. Disinfection efficacy and mechanism of olanexidine gluconate against norovirus. Am J Infect Control. 2022 Jul;50(7):764-771.  [Content Brief]

  [4]. Nakata H, et al. Effects of olanexidine gluconate on preoperative skin preparation: an experimental study in cynomolgus monkeys. J Med Microbiol. 2017 May;66(5):678-685.  [Content Brief]