Olanexidine hydrochloride
Based on 1 Customer Validation
Olanexidine hydrochloride is a monobiguanide compound with bactericidal activity. Olanexidine probably binds to the cell membrane, destroys membrane integrity. Olanexidine hydrochloride is active against a wide range of bacteria, including Gram-positive and Gram-negative bacteria. Olanexidine exhibits the bactericidal concentration of 109 μg/mL for Gram-positive bacilli.
For research use only. We do not sell to patients.
- Purity: 96.46%
- CAS No.: 146509-94-6
- Formula: C17H28Cl3N5
- Molecular Weight:408.80
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Olanexidine shows a bactericidal mechanism of (i) interacts with the bacterial surface molecules, such as lipopolysaccharide and lipoteichoic acid, (ii) disrupts the cell membranes of liposomes, which are artificial bacterial membrane models, (iii) enhances the membrane permeability of Escherichia coli, (iv) disrupts the membrane integrity of S. aureus, and (v) denatures proteins at relatively high concentrations (≥160 μg/ml)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 146509-94-6
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Appearance Solid
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Molecular Weight 408.80
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Formula C17H28Cl3N5
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Color White to off-white
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SMILES
N=C(NC(NCCCCCCCC)=N)NCC1=CC=C(C(Cl)=C1)Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 62.5 mg/mL (152.89 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4462 mL | 12.2309 mL | 24.4618 mL | 61.1546 mL |
| 5 mM | 0.4892 mL | 2.4462 mL | 4.8924 mL | 12.2309 mL | |
| 10 mM | 0.2446 mL | 1.2231 mL | 2.4462 mL | 6.1155 mL | |
| 15 mM | 0.1631 mL | 0.8154 mL | 1.6308 mL | 4.0770 mL | |
| 20 mM | 0.1223 mL | 0.6115 mL | 1.2231 mL | 3.0577 mL | |
| 25 mM | 0.0978 mL | 0.4892 mL | 0.9785 mL | 2.4462 mL | |
| 30 mM | 0.0815 mL | 0.4077 mL | 0.8154 mL | 2.0385 mL | |
| 40 mM | 0.0612 mL | 0.3058 mL | 0.6115 mL | 1.5289 mL | |
| 50 mM | 0.0489 mL | 0.2446 mL | 0.4892 mL | 1.2231 mL | |
| 60 mM | 0.0408 mL | 0.2038 mL | 0.4077 mL | 1.0192 mL | |
| 80 mM | 0.0306 mL | 0.1529 mL | 0.3058 mL | 0.7644 mL | |
| 100 mM | 0.0245 mL | 0.1223 mL | 0.2446 mL | 0.6115 mL |
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