P-gp inhibitor 4
P-gp inhibitor 4 (Compound 8b) is a selective P-glycoprotein modulator with an EC50 of 94 nM. P-gp inhibitor 4 increases agent transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells.
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- CAS No.: 2652001-05-1
- Formule: C38H38N2O8S2
- Masse moléculaire:714.85
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
EC50: 94 nM (P-glycoprotein)[1]
P-gp inhibitor 4 (Compound 8b) (0-1 μM, 48 h) significantly increases the cytotoxic effect of antineoplastic drug with co-administration[1].
P-gp inhibitor 4 does not alter the physiological properties of Caco-2 cells barrier model[1].
P-gp inhibitor 4 selectively reduces the activity of P-gp and increases the transport of multiple P-gp substrates across gastro-intestinal barrier[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDCK-MDR1
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Concentration:100 nM, 500 nM and 1 μM
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Incubation Time:48 h
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Result:Showed no cytotoxicity. Significantly increased the cytotoxic effect of antineoplastic drug.
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Cell Line:Caco-2 cells
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Concentration:0.1 nM-100 µM
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Incubation Time:72 h
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Result:Displayed a dose-dependence cytotoxicity that was significant at ≥ 10 μM concentration. Did not reduce cell viability at 100 nM.
Chemical Information
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CAS No. 2652001-05-1
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Masse moléculaire 714.85
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Formule C38H38N2O8S2
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SMILES
COC1=CC=C(C=C1)S(=O)(N(S(=O)(C2=CC=C(C=C2)OC)=O)C3=CC=C(C=C3)C4=CC=C(C=C4)CN5CCC6=CC(OC)=C(C=C6C5)OC)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
P-gp inhibitor 4 Related Classifications
HY-146391 Related Classifications
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