P-gp inhibitor 4 

P-gp inhibitor 4 (Compound 8b) is a selective P-glycoprotein modulator with an EC₅₀ of 94 nM. P-gp inhibitor 4 increases agent transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells^[1].

EC₅₀: 94 nM (P-glycoprotein)^[1]

P-gp inhibitor 4 (Compound 8b) (0-1 μM, 48 h) significantly increases the cytotoxic effect of antineoplastic drug with co-administration^[1].
P-gp inhibitor 4 does not alter the physiological properties of Caco-2 cells barrier model^[1].
P-gp inhibitor 4 selectively reduces the activity of P-gp and increases the transport of multiple P-gp substrates across gastro-intestinal barrier^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

714.85

C₃₈H₃₈N₂O₈S₂

2652001-05-1

COC1=CC=C(C=C1)S(=O)(N(S(=O)(C2=CC=C(C=C2)OC)=O)C3=CC=C(C=C3)C4=CC=C(C=C4)CN5CCC6=CC(OC)=C(C=C6C5)OC)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Contino M, et al. One molecule two goals: A selective P-glycoprotein modulator increases drug transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells. Eur J Med Chem. 2020 Dec 15;208:112843.  [Content Brief]