2652001-05-1
Chemical Structure
P-gp inhibitor 4
- CAS. Nr.: 2652001-05-1
- Formula:C38H38N2O8S2
- Molecular Weight:714.85
IUPAC Name: N-(4'-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-[1,1'-biphenyl]-4-yl)-4-methoxy-N-((4-methoxyphenyl)sulfonyl)benzenesulfonamide
InChIKey: OLEIDKRBRKPLJH-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)S(=O)(N(S(=O)(C2=CC=C(C=C2)OC)=O)C3=CC=C(C=C3)C4=CC=C(C=C4)CN5CCC6=CC(OC)=C(C=C6C5)OC)=O
Biological Activity: P-gp inhibitor 4 (Compound 8b) is a selective P-glycoprotein modulator with an EC50 of 94 nM. P-gp inhibitor 4 increases agent transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells[1].
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P-gp inhibitor 4 | P-gp inhibitor 4 (Compound 8b) is a selective P-glycoprotein modulator with an EC50 of 94 nM. P-gp inhibitor 4 increases agent transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells. | |||||||||||||||||||||
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Keywords
