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Cat. No.: HY-P99108A

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Penpulimab (Anti-PD-1)

Name: Penpulimab (Anti-PD-1)
Brand: MedChemExpress
SKU: HY-P99108A
Availability: PreOrder

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Penpulimab (Anti-PD-1) is an IgG1 backbone anti-PD-1 monoclonal antibody with antitumor activities.

For research use only. We do not sell to patients.

CAS No.: 2350298-92-7

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Penpulimab (Anti-PD-1) Chemical Structure

CAS No.: 2350298-92-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Penpulimab (Anti-PD-1) is an IgG1 backbone anti-PD-1 monoclonal antibody with antitumor activities^[1].

Isotype

Human IgG1 (L234A/L235A) kappa

Recommend Isotype Controls

Human IgG1 (L234A/L235A) kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

PDCD1/PD-1/CD279

In Vitro

Penpulimab (Anti-PD-1) demonstrates better stability and a lower level of host-cell protein residue compared with IgG4 backbone anti-PD-1 antibodies^[1].
Penpulimab (Anti-PD-1) does not mediate complement-dependent cytotoxicity (CDC) or antibody-dependent cell-mediated cytotoxicity (ADCC) and induces no remarkable IL-6 and IL-8 release by activated macrophages^[1].
Penpulimab (Anti-PD-1) exhibits slower binding off-rate for human PD-1 than Nivolumab (HY-P9903) and Pembrolizumab (HY-P9902)^[1].
Penpulimab (Anti-PD-1) potentiates T cell activation via PD-1/PD-L1 blockade^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Penpulimab (Anti-PD-1) (5 mg/kg; i.p.; twice a week, 3weeks) inhibits tumor growth in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

MC38-hPD-L1 tumor-bearing B-hPD-1 humanized mouse model^[2]
Dosage:

5 mg/kg
Administration:

IP, twice a week, 3weeks
Result:

Showed moderate inhibition of tumor growth (tumor volume: 58.4% of control group). Treatment combined with anlotinib (1 mg/kg, every day, p.o) significantly decreased tumor volume to 36.5% of control group.

Gene ID

5133 [NCBI]

Accession

Q15116

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

IgG1-kappa

Application

ELISA, FACS, Functional assay

Chemical Information

CAS No. 2350298-92-7
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

bioRxiv

2025 Sep 7.

Purity & Documentation

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Huang Z, et al. Penpulimab, an Fc-Engineered IgG1 Anti-PD-1 Antibody, With Improved Efficacy and Low Incidence of Immune-Related Adverse Events. Front Immunol. 2022 Jun 27;13:924542. [Content Brief]

[2]. Yunlong Shan, et al. Anlotinib enhanced penpulimab efficacy through remodeling of tumor vascular architecture and immune microenvironment in hPD-L1/hPD-1 humanized mouse model. Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021) 2581-2581.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

Penpulimab (Anti-PD-1)

1 Cited Publications

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Amount: USD 0.00

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Publications (1)
Purity & Documentation
References

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Penpulimab (Anti-PD-1)

Publications Citing Use of MedChemExpress (MCE) Penpulimab (Anti-PD-1)