Penpulimab (Anti-PD-1)
Based on 1 publication(s) in Google Scholar
Penpulimab (Anti-PD-1) is an IgG1 backbone anti-PD-1 monoclonal antibody with antitumor activities.
For research use only. We do not sell to patients.
- CAS No.: 2350298-92-7
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Publications Citing Use of MedChemExpress (MCE) Penpulimab (Anti-PD-1)
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Biological Activity
Human IgG1 (L234A/L235A) kappa
Human
PDCD1/PD-1/CD279
Penpulimab (Anti-PD-1) demonstrates better stability and a lower level of host-cell protein residue compared with IgG4 backbone anti-PD-1 antibodies[1].
Penpulimab (Anti-PD-1) does not mediate complement-dependent cytotoxicity (CDC) or antibody-dependent cell-mediated cytotoxicity (ADCC) and induces no remarkable IL-6 and IL-8 release by activated macrophages[1].
Penpulimab (Anti-PD-1) exhibits slower binding off-rate for human PD-1 than Nivolumab (HY-P9903) and Pembrolizumab (HY-P9902)[1].
Penpulimab (Anti-PD-1) potentiates T cell activation via PD-1/PD-L1 blockade[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MC38-hPD-L1 tumor-bearing B-hPD-1 humanized mouse model[2]
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Dosage:5 mg/kg
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Administration:IP, twice a week, 3weeks
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Result:Showed moderate inhibition of tumor growth (tumor volume: 58.4% of control group). Treatment combined with anlotinib (1 mg/kg, every day, p.o) significantly decreased tumor volume to 36.5% of control group.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG1-kappa
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 2350298-92-7
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Penpulimab (Anti-PD-1) Related Classifications
HY-P99108A Related Classifications
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