1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. Penpulimab

Penpulimab 

Cat. No.: HY-P99108

Penpulimab is an IgG1 backbone anti-PD-1 monoclonal antibody with antitumor activities.

For research use only. We do not sell to patients.

Penpulimab Chemical Structure

Penpulimab Chemical Structure

CAS No. : 2350298-92-7

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Description

Penpulimab is an IgG1 backbone anti-PD-1 monoclonal antibody with antitumor activities[1].

In Vitro

Penpulimab demonstrates better stability and a lower level of host-cell protein residue compared with IgG4 backbone anti-PD-1 antibodies[1].
Penpulimab does not mediate complement-dependent cytotoxicity (CDC) or antibody-dependent cell-mediated cytotoxicity (ADCC) and induces no remarkable IL-6 and IL-8 release by activated macrophages[1].
Penpulimab exhibits slower binding off-rate for human PD-1 than Nivolumab (HY-P9903) and Pembrolizumab (HY-P9902)[1].
Penpulimab potentiates T cell activation via PD-1/PD-L1 blockade[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Penpulimab (5 mg/kg; i.p.; twice a week, 3weeks) inhibits tumor growth in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MC38-hPD-L1 tumor-bearing B-hPD-1 humanized mouse model[2]
Dosage: 5 mg/kg
Administration: IP, twice a week, 3weeks
Result: Showed moderate inhibition of tumor growth (tumor volume: 58.4% of control group). Treatment combined with anlotinib (1 mg/kg, every day, p.o) significantly decreased tumor volume to 36.5% of control group.
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[Penpulimab]

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