2. PROTAC
  3. Ligands for E3 Ligase
  4. Phenyl-glutarimide 4'-oxyacetic acid

Phenyl-glutarimide 4 ’-oxyacetic acid is a carboxylic acid-functionalized cerebellar ligand that can be used in the development of PROTAC deactivators. Phenyl-glutarimide 4 ’-oxyacetic acid binds to PROTAC has better hydrolytic stability and efficacy.

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Phenyl-glutarimide 4'-oxyacetic acid

Phenyl-glutarimide 4'-oxyacetic acid Chemical Structure

CAS No. : 2782024-58-0

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Phenyl-glutarimide 4'-oxyacetic acid Related Antibodies

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View All Ligands for E3 Ligase Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

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Description

Phenyl-glutarimide 4 ’-oxyacetic acid is a carboxylic acid-functionalized cerebellar ligand that can be used in the development of PROTAC deactivators. Phenyl-glutarimide 4 ’-oxyacetic acid binds to PROTAC has better hydrolytic stability and efficacy[1].

IC50 & Target

Cereblon

 

Molecular Weight

263.25

Formula

C13H13NO5
CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

O=C(COC1=CC=C(C2C(NC(CC2)=O)=O)C=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5.83 mg/mL (22.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7987 mL 18.9934 mL 37.9867 mL
5 mM 0.7597 mL 3.7987 mL 7.5973 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7987 mL 18.9934 mL 37.9867 mL 94.9668 mL
5 mM 0.7597 mL 3.7987 mL 7.5973 mL 18.9934 mL
10 mM 0.3799 mL 1.8993 mL 3.7987 mL 9.4967 mL
15 mM 0.2532 mL 1.2662 mL 2.5324 mL 6.3311 mL
20 mM 0.1899 mL 0.9497 mL 1.8993 mL 4.7483 mL
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Phenyl-glutarimide 4'-oxyacetic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phenyl-glutarimide 4'-oxyacetic acid2782024-58-0Ligands for E3 LigaseE3 ligase-recruiting Moietycerebellar ligandPROTACPGInhibitorinhibitorinhibit

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