PHGDH-IN-5

製品番号: HY-161456 純度: 98.12%: Data Sheet SDS COA 取扱説明書
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PHGDH-IN-5 (Compound B12) is a covalen inhibitor of PHGDH with an IC₅₀ value of 0.29 μM. PHGDH-IN-5 can inhibit cell proliferation in cancer cell lines overexpressing PHGDH. PHGDH-IN-5 can reduce the production of serine derived from glucose in MDA-MB-468 cells.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

PHGDH-IN-5 構造式

CAS 番号 : 17402-86-7

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 209	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 209	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$190	在庫あり	Estimated Time of Arrival: December 31
10 mg	$300	在庫あり	Estimated Time of Arrival: December 31
25 mg	$600	在庫あり	Estimated Time of Arrival: December 31
50 mg	$960	在庫あり	Estimated Time of Arrival: December 31
100 mg	$1540	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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•関連タンパク質:

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

IC50: 0.29 μM (PHGDH)^[1].

体外実験

PHGDH-IN-5 can inhibit the proliferation of MDA-MB-468, NCI-H1975, HT1080, and PC9 cells, with IC₅₀ values ranging from 9.93 μM to 21.2 μM^[1].
PHGDH-IN-5 (10-30 μM) reduces the production of M+3-serine derived from 13C6-glucose in MDA-MB-468 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

211.19

分子式

C₈H₅NO₄S

CAS 番号

17402-86-7

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=S1(C2=CC=CC([N+]([O-])=O)=C2C=C1)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (473.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7351 mL	23.6754 mL	47.3507 mL
5 mM	0.9470 mL	4.7351 mL	9.4701 mL
10 mM	0.4735 mL	2.3675 mL	4.7351 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (23.68 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 98.12%

Select Batch:

データシート (278 KB) SDS (251 KB)

COA (258 KB) HNMR (243 KB) LCMS (97 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Cao XY, et al. Identification of benzo[b]thiophene-1,1-dioxide derivatives as novel PHGDH covalent inhibitors. Bioorg Chem. 2024;146:107330. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.7351 mL	23.6754 mL	47.3507 mL	118.3768 mL
	5 mM	0.9470 mL	4.7351 mL	9.4701 mL	23.6754 mL
	10 mM	0.4735 mL	2.3675 mL	4.7351 mL	11.8377 mL
	15 mM	0.3157 mL	1.5784 mL	3.1567 mL	7.8918 mL
	20 mM	0.2368 mL	1.1838 mL	2.3675 mL	5.9188 mL
	25 mM	0.1894 mL	0.9470 mL	1.8940 mL	4.7351 mL
	30 mM	0.1578 mL	0.7892 mL	1.5784 mL	3.9459 mL
	40 mM	0.1184 mL	0.5919 mL	1.1838 mL	2.9594 mL
	50 mM	0.0947 mL	0.4735 mL	0.9470 mL	2.3675 mL
	60 mM	0.0789 mL	0.3946 mL	0.7892 mL	1.9729 mL
	80 mM	0.0592 mL	0.2959 mL	0.5919 mL	1.4797 mL
	100 mM	0.0474 mL	0.2368 mL	0.4735 mL	1.1838 mL

PHGDH-IN-5 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PHGDH-IN-517402-86-7Phosphoglycerate Dehydrogenase (PHGDH)MDA-MB-468、NCI-H1975、HT1080PC9cancerInhibitorinhibitorinhibit

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