Art. -Nr.: HY-N3056

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Pinosylvin monomethyl ether

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Pinosylvin monomethyl ether has antibacterial effect and fungicidal activity.

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Reinheit: 99.98%
CAS. Nr.: 35302-70-6
Formel: C₁₅H₁₄O₂
Molecular Weight:226.27

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Pinosylvin monomethyl ether Chemical Structure

CAS. Nr.: 35302-70-6

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Pinosylvin monomethyl ether has antibacterial effect^[1] and fungicidal activity^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	10 μg/mL Compound: page 258, C1R33	Cytotoxicity against human A2780 cells by clonogenic assay Cytotoxicity against human A2780 cells by clonogenic assay	[PMID: 16499333]
HEK293	EC₅₀	3.5 μM Compound: 8	Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as induction of intracellular calcium level Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as induction of intracellular calcium level	[PMID: 26750258]
HEK293	IC₅₀	>10 μM Compound: 8	Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase of intracellular calcium level Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase of intracellular calcium level	[PMID: 26750258]
HEK293	IC₅₀	15 μM Compound: 8	Antagonist activity at human TRPV1 expressed in HEK293 cells Antagonist activity at human TRPV1 expressed in HEK293 cells	[PMID: 26750258]
HEK293	IC₅₀	23.7 μM Compound: 8	Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase of intracellular calcium level Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase of intracellular calcium level	[PMID: 26750258]
HEK293	IC₅₀	6.9 μM Compound: 8	Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase of intracellular calcium level Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase of intracellular calcium level	[PMID: 26750258]
J774	IC₅₀	23.7 μM Compound: 2	Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced MCP1 expression after 24 hrs by ELISA Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced MCP1 expression after 24 hrs by ELISA	[PMID: 29726680]
J774	IC₅₀	30.2 μM Compound: 2	Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced IL6 expression after 24 hrs by ELISA Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced IL6 expression after 24 hrs by ELISA	[PMID: 29726680]
J774	IC₅₀	37 μM Compound: 2	Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced nitric oxide production after 24 hrs by Griess assay Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 29726680]
RAW264.7	IC₅₀	10.5 μM Compound: 2	inhibitory concentration against PGE-2 production in LPS-stimulated RAW264.7 cells inhibitory concentration against PGE-2 production in LPS-stimulated RAW264.7 cells	[PMID: 15501064]

Chemical Information

CAS. Nr. 35302-70-6
Appearance Solid
Molecular Weight 226.27
Formel C₁₅H₁₄O₂
Color White to off-white
SMILES

OC1=CC(/C=C/C2=CC=CC=C2)=CC(OC)=C1
Structure Classification
- Phenols
- Monophenols
- Stilbenes
Initial Source
- Plants
- other families
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (441.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.4195 mL

22.0975 mL

44.1950 mL

5 mM

0.8839 mL

4.4195 mL

8.8390 mL

10 mM

0.4419 mL

2.2097 mL

4.4195 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (11.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (11.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lindberg LE, Willför SM, Holmbom BR. Antibacterial effects of knotwood extractives on paper mill bacteria. J Ind Microbiol Biotechnol. 2004;31(3):137-147. [Content Brief]

[2]. Schultz T P,et al. Structure-fungicidal properties of some 3- and 4-hydroxylated stilbenes and bibenzyl analogues[J]. Phytochemistry, 1992, 31(11):3801–3806.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.4195 mL	22.0975 mL	44.1950 mL	110.4875 mL
	5 mM	0.8839 mL	4.4195 mL	8.8390 mL	22.0975 mL
	10 mM	0.4419 mL	2.2097 mL	4.4195 mL	11.0487 mL
	15 mM	0.2946 mL	1.4732 mL	2.9463 mL	7.3658 mL
	20 mM	0.2210 mL	1.1049 mL	2.2097 mL	5.5244 mL
	25 mM	0.1768 mL	0.8839 mL	1.7678 mL	4.4195 mL
	30 mM	0.1473 mL	0.7366 mL	1.4732 mL	3.6829 mL
	40 mM	0.1105 mL	0.5524 mL	1.1049 mL	2.7622 mL
	50 mM	0.0884 mL	0.4419 mL	0.8839 mL	2.2097 mL
	60 mM	0.0737 mL	0.3683 mL	0.7366 mL	1.8415 mL
	80 mM	0.0552 mL	0.2762 mL	0.5524 mL	1.3811 mL
	100 mM	0.0442 mL	0.2210 mL	0.4419 mL	1.1049 mL

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Pinosylvin monomethyl ether

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Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Pinosylvin monomethyl ether

Bioactive Compound Library Max

Bioactive Compound Library

Anti-Infection Compound Library

Natural Product Library

Lipid Compound Library

Antifungal Compound Library

Antibacterial Compound Library

Phenols Library

Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Anti-Pulmonary Fibrosis Compound Library

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Natural Product Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Pinosylvin monomethyl ether Related Classifications

HY-N3056 Related Classifications