2. Anti-infection Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Stem Cell/Wnt MAPK/ERK Pathway
  3. HCV Branched Chain Amino Acid Transaminase (BCAT) Interleukin Related NF-κB ERK p38 MAPK JNK
  4. Platycodin D3

Platycodin D3 is a triterpenoid saponin that can be found in Platycodon grandiflorum. Platycodin D3 exhibits multiple activities including anti-inflammation, regulation of airway mucus secretion, improvement of asthmatic airway inflammation and remodeling, and inhibition of hepatitis C virus (HCV) replication. The IC50 value of Platycodin D3 against HCV NS5B RNA-dependent RNA polymerase is 8 μg/mL. Platycodin D3 can be used in studies related to asthma, hepatitis C virus infection and inflammatory diseases.

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Platycodin D3

Platycodin D3 Chemical Structure

CAS No. : 67884-03-1

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Based on 1 publication(s) in Google Scholar

Platycodin D3 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Platycodin D3

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Description

Platycodin D3 is a triterpenoid saponin that can be found in Platycodon grandiflorum. Platycodin D3 exhibits multiple activities including anti-inflammation, regulation of airway mucus secretion, improvement of asthmatic airway inflammation and remodeling, and inhibition of hepatitis C virus (HCV) replication. The IC50 value of Platycodin D3 against HCV NS5B RNA-dependent RNA polymerase is 8 μg/mL. Platycodin D3 can be used in studies related to asthma, hepatitis C virus infection and inflammatory diseases[1][2][3][4].

In Vitro

Platycodin D3 inhibits the activity of HCV NS5B RdRp with an IC50 of 8 μg/mL, and does not inhibit the activity of HCV NS3/4A protease[1].
Platycodin D3 (72 h) inhibits RNA replication of HCV genotype 1b in Huh7 replicon cells, with an EC50 of 2.33 μg/mL and a CC50 of 100 μg/mL in Huh7 cells, indicating low cytotoxicity[1].
Platycodin D3 (48 h) inhibits HCV genotype 2a (JFH1) RNA replication in infected Huh7 cells, with an EC50 of 27 μg/mL[1].
Platycodin D3 (0.5-5 μg/mL; 3 days) dose-dependently inhibits the expression of HCV NS5A protein in Huh7 cells harboring the subgenomic replicon of HCV genotype 1b[1].
Platycodin D3 (0-60 μM; 24 h) dose-dependently inhibits nitric oxide production in RAW 264.7 cells activated by LPS (HY-D1056) and IFN-γ, with an IC50 of 55 μM, and shows no cytotoxicity at concentrations up to 60 μM[2].
Platycodin D3 (20-50 μM; 16-24 h) dose-dependently inhibits iNOS protein expression and upregulates TNF-α mRNA expression in RAW 264.7 cells activated by LPS and IFN-γ[2].
Platycodin D3 (1-100 μM; 30 min pre-incubation) inhibits the production and secretion of MUC5AC mucin in PMA (HY-18739)-induced NCI-H292 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Platycodin D3 Related Antibodies

Western Blot Analysis[1]

Cell Line: Huh7 cells harboring HCV genotype 1b subgenomic replicon
Concentration: 0.5, 1, 5 μg/mL
Incubation Time: 3 days
Result: Prominently reduced HCV NS5A protein expression in a dose-dependent manner.
Resulted in near-complete inhibition of NS5A protein levels relative to untreated controls at 5 μg/mL.
In Vivo

Platycodin D3 (20-80 mg/kg/d for 8 weeks) reduces airway hyperresponsiveness, inflammatory responses, and pathological damage in asthmatic mice in a dose-dependent manner in vivo[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (male, 6-8 weeks old, 18-20 g, ovalbumin + aluminum hydroxide-induced asthma)[4]
Dosage: 20 mg/kg/d; 40 mg/kg/d; 80 mg/kg/d
Administration: daily; 8 weeks
Result: Enhanced airway dynamic compliance and reduced total airway resistance in a dose-dependent manner following methacholine challenge.
Reduced total inflammatory cells, eosinophils, macrophages, lymphocytes, and neutrophils in BALF in a dose-dependent manne.
Reduced BALF levels of eotaxin, IL-4, IL-5, IL-13, IFN-γ, and serum IgE in a dose-dependent manner.
Reduced lung tissue inflammatory cell infiltration, mucus hypersecretion, and goblet cell hyperplasia in a dose-dependent manner via HE and PAS staining.
Inhibited phosphorylation of NF-κBp65, p38, ERK1/2, and JNK1/2 proteins in lung tissue.
Molecular Weight

1387.46

Formula

C63H102O33
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C(C(OC1C(C(C(O)CO1)OC2C(C(CO)(O)CO2)O)O)C(C)O3)O)C3OC(C(C(O)CO4)O)C4OC(C56C(CC(C)(C)CC6)C7=CCC(C8(C(C(CO)(C(OC9OC(C(O)C(O)C9O)COC%10OC(C(O)C(O)C%10O)CO)C(O)C8)CO)CC%11)C)C%11(C)C7(C)CC5O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: 98.91%

SDS (252 KB)

COA (251 KB) HNMR (139 KB) CNMR (139 KB) RP-HPLC (115 KB) MS (119 KB)

Handling Instructions (2659 KB)
References
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Platycodin D3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Platycodin D367884-03-1Platycodin D 3Platycodin D-3HCVBranched Chain Amino Acid Transaminase (BCAT)Interleukin RelatedNF-κBERKp38 MAPKJNKHepatitis C virusBranched Chain Amino Acid Transaminase, Branched-Chain amino acids aminotransferaseILNuclear factor-κBNuclear factor-kappaBExtracellular signal regulated kinasesc-Jun N-terminal kinaseNCI-H292 cellsERK1/2Huh7 cellsRAW 264.7 cellsNF-κBp65p38 proteinshuman HCV NS5B RNA-dependent RNA polymeraseasthmatic miceJNK1/2Platycodon grandiflorumInhibitorinhibitorinhibit

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