Cat. No.: HY-N3519

Platycodin D3

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Platycodin D3 is a triterpenoid saponin that can be found in Platycodon grandiflorum. Platycodin D3 exhibits multiple activities including anti-inflammation, regulation of airway mucus secretion, improvement of asthmatic airway inflammation and remodeling, and inhibition of hepatitis C virus (HCV) replication. The IC₅₀ value of Platycodin D3 against HCV NS5B RNA-dependent RNA polymerase is 8 μg/mL. Platycodin D3 can be used in studies related to asthma, hepatitis C virus infection and inflammatory diseases.

For research use only. We do not sell to patients.

Purity: 98.91%
CAS No.: 67884-03-1
Formula: C₆₃H₁₀₂O₃₃
Molecular Weight:1387.46

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Platycodin D3 Chemical Structure

CAS No.: 67884-03-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
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References
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Biological Activity

Description

All Interleukin Related Isoforms :

All NF-κB Isoforms :

All ERK Isoforms :

All p38 MAPK Isoforms :

All JNK Isoforms :

In Vitro

Platycodin D3 inhibits the activity of HCV NS5B RdRp with an IC₅₀ of 8 μg/mL, and does not inhibit the activity of HCV NS3/4A protease^[1].
Platycodin D3 (72 h) inhibits RNA replication of HCV genotype 1b in Huh7 replicon cells, with an EC₅₀ of 2.33 μg/mL and a CC₅₀ of 100 μg/mL in Huh7 cells, indicating low cytotoxicity^[1].
Platycodin D3 (48 h) inhibits HCV genotype 2a (JFH1) RNA replication in infected Huh7 cells, with an EC₅₀ of 27 μg/mL^[1].
Platycodin D3 (0.5-5 μg/mL; 3 days) dose-dependently inhibits the expression of HCV NS5A protein in Huh7 cells harboring the subgenomic replicon of HCV genotype 1b^[1].
Platycodin D3 (0-60 μM; 24 h) dose-dependently inhibits nitric oxide production in RAW 264.7 cells activated by LPS (HY-D1056) and IFN-γ, with an IC₅₀ of 55 μM, and shows no cytotoxicity at concentrations up to 60 μM^[2].
Platycodin D3 (20-50 μM; 16-24 h) dose-dependently inhibits iNOS protein expression and upregulates TNF-α mRNA expression in RAW 264.7 cells activated by LPS and IFN-γ^[2].
Platycodin D3 (1-100 μM; 30 min pre-incubation) inhibits the production and secretion of MUC5AC mucin in PMA (HY-18739)-induced NCI-H292 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Huh7 cells harboring HCV genotype 1b subgenomic replicon
Concentration:

0.5, 1, 5 μg/mL
Incubation Time:

3 days
Result:

Prominently reduced HCV NS5A protein expression in a dose-dependent manner.
Resulted in near-complete inhibition of NS5A protein levels relative to untreated controls at 5 μg/mL.

In Vivo

Platycodin D3 (20-80 mg/kg/d for 8 weeks) reduces airway hyperresponsiveness, inflammatory responses, and pathological damage in asthmatic mice in a dose-dependent manner in vivo^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (male, 6-8 weeks old, 18-20 g, ovalbumin + aluminum hydroxide-induced asthma)^[4]
Dosage:

20 mg/kg/d; 40 mg/kg/d; 80 mg/kg/d
Administration:

daily; 8 weeks
Result:

Enhanced airway dynamic compliance and reduced total airway resistance in a dose-dependent manner following methacholine challenge.
Reduced total inflammatory cells, eosinophils, macrophages, lymphocytes, and neutrophils in BALF in a dose-dependent manne.
Reduced BALF levels of eotaxin, IL-4, IL-5, IL-13, IFN-γ, and serum IgE in a dose-dependent manner.
Reduced lung tissue inflammatory cell infiltration, mucus hypersecretion, and goblet cell hyperplasia in a dose-dependent manner via HE and PAS staining.
Inhibited phosphorylation of NF-κBp65, p38, ERK1/2, and JNK1/2 proteins in lung tissue.

Chemical Information

CAS No. 67884-03-1
Appearance Solid
Molecular Weight 1387.46
Formula C₆₃H₁₀₂O₃₃
Color White to off-white
SMILES

OC(C(C(OC1C(C(C(O)CO1)OC2C(C(CO)(O)CO2)O)O)C(C)O3)O)C3OC(C(C(O)CO4)O)C4OC(C56C(CC(C)(C)CC6)C7=CCC(C8(C(C(CO)(C(OC9OC(C(O)C(O)C9O)COC%10OC(C(O)C(O)C%10O)CO)C(O)C8)CO)CC%11)C)C%11(C)C7(C)CC5O)=O
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kim JW, et al. Triterpenoid Saponins Isolated from Platycodon grandiflorum Inhibit Hepatitis C Virus Replication. Evid Based Complement Alternat Med. 2013;2013:560417. [Content Brief]

[2]. Wang C, et al. Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-alpha in activated RAW 264.7 cells. Int Immunopharmacol. 2004;4(8):1039-1049. [Content Brief]

[3]. Ryu J, et al. Effects of the root of Platycodon grandiflorum on airway mucin hypersecretion in vivo and platycodin D(3) and deapi-platycodin on production and secretion of airway mucin in vitro. Phytomedicine. 2014;21(4):529-533. [Content Brief]

[4]. Peng F, et al. Protective Effects of Platycodin D3 on Airway Remodeling and Inflammation via Modulating MAPK/NF-κB Signaling Pathway in Asthma Mice. Evid Based Complement Alternat Med. 2022;2022:1612829. Published 2022 Aug 10. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Platycodin D3

1 Cited Publications

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Platycodin D3

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