Antitumor effects of dammarane-type saponins from steamed Notoginseng

  • Pharmacogn Mag. 2014 Jul;10(39):314-7. doi: 10.4103/0973-1296.137372.
Fan He  1 ,  Yan Ding  2 ,  Chun Liang  3 ,  Seok Bean Song  4 ,  De-Qiang Dou  1 ,  Gyu Yong Song  4 ,  Young Ho Kim  4
Affiliations
  • 1. Department of Pharmacognosy, Liaoning University of Traditional Chinese Medicine, Dalian, China.
  • 2. Institute of Chemistry and Applications of Plant Resources, Dalian Polytechnic University, Dalian, China.
  • 3. Herbal Medicine Improvement Research Center, Korea Institute of Oriental Medicine, Daejeon, Korea.
  • 4. College of Pharmacy, Chungnam National University, Daejeon, Korea.
PMID: 25210319 DOI: 10.4103/0973-1296.137372
Abstract

Six dammarane-type saponins were extracted from steamed Panax notoginseng. Their chemical structures were identified spectroscopically as ginsenosides Rh1 (1), Rg1 (2), 20 (S)-Rg3 (3), 20 (R)-Rg3 (4), Rb3 (5), and Rb1 (6). Compounds (0.1-10 μM) were tested for inhibition of tumor necrosis factor-α (TNF)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) luciferase reporter activity using a human kidney 293T cell-based assay. Ginsenoside Rb3 (5) showed the most significant activity with an IC50 of 8.2 μM. This compound also inhibited the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger Ribonucleic acid (mRNA) in a dose-dependent manner after HepG2 cells had been treated with TNF-α (10 ng/mL).

Keywords
Antitumor; Panax notoginseng; dammarane-type ginsenoside; inhibitory activity.
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