2. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  3. EGFR
  4. (Rac)-JBJ-04-125-02

(Rac)-JBJ-04-125-02 

Cat. No.: HY-135805A Purity: 98.01%
COA Handling Instructions

(Rac)-JBJ-04-125-02 is the racemate of JBJ-04-125-02. JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor.

For research use only. We do not sell to patients.

(Rac)-JBJ-04-125-02 Chemical Structure

(Rac)-JBJ-04-125-02 Chemical Structure

CAS No. : 2140807-05-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 308 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 308 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 280 In-stock
Estimated Time of Arrival: December 31
10 mg USD 450 In-stock
Estimated Time of Arrival: December 31
25 mg USD 880 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1400 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (Rac)-JBJ-04-125-02:

Top Publications Citing Use of Products

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • Biological Activity

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  • Customer Review

Description

(Rac)-JBJ-04-125-02 is the racemate of JBJ-04-125-02. JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor[1].

IC50 & Target[1]

EGFR (L858R/T790M)

0.26 nM (IC50)

In Vitro

JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 0.26 nM for EGFRL858R/T790M[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

543.61

Appearance

Solid

Formula

C29H26FN5O3S
CAS No.
SMILES

O=C(NC1=NC=CS1)C(C2=CC(F)=CC=C2O)N(CC3=C4C=C(C5=CC=C(N6CCNCC6)C=C5)C=C3)C4=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (459.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8396 mL 9.1978 mL 18.3955 mL
5 mM 0.3679 mL 1.8396 mL 3.6791 mL
10 mM 0.1840 mL 0.9198 mL 1.8396 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (3.83 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (3.83 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.83 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.01%

COA (251 KB) HNMR (297 KB) LCMS (142 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

(Rac)-JBJ-04-125-022140807-05-0EGFREpidermal growth factor receptorErbB-1HER1Allostericanti-proliferationT790M-mutantanti-tumorracemateInhibitorinhibitorinhibit

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