1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
  3. (Rac)-JBJ-04-125-02

(Rac)-JBJ-04-125-02 

Cat. No.: HY-135805A Purity: 98.01%
Handling Instructions

(Rac)-JBJ-04-125-02 is the racemate of JBJ-04-125-02. JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 0.26 nM for EGFRL858R/T790M.

For research use only. We do not sell to patients.

(Rac)-JBJ-04-125-02 Chemical Structure

(Rac)-JBJ-04-125-02 Chemical Structure

CAS No. : 2140807-05-0

Size Price Stock Quantity
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (Rac)-JBJ-04-125-02:

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Description

(Rac)-JBJ-04-125-02 is the racemate of JBJ-04-125-02. JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 0.26 nM for EGFRL858R/T790M[1].

IC50 & Target

EGFR (L858R/T790M)

0.26 nM (IC50)

Molecular Weight

543.61

Formula

C₂₉H₂₆FN₅O₃S

CAS No.

2140807-05-0

SMILES

O=C(NC1=NC=CS1)C(C2=CC(F)=CC=C2O)N(CC3=C4C=C(C5=CC=C(N6CCNCC6)C=C5)C=C3)C4=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (459.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8396 mL 9.1978 mL 18.3955 mL
5 mM 0.3679 mL 1.8396 mL 3.6791 mL
10 mM 0.1840 mL 0.9198 mL 1.8396 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (3.83 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (3.83 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.83 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.01%

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Keywords:

(Rac)-JBJ-04-125-02EGFREpidermal growth factor receptorErbB-1HER1Allostericanti-proliferationT790M-mutantanti-tumorracemateInhibitorinhibitorinhibit

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Product Name:
(Rac)-JBJ-04-125-02
Cat. No.:
HY-135805A
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