CTNNA1 Protein, Human (sf9, GST)
CTNNA1 Protein, Human (sf9, GST) is the recombinant human-derived CTNNA1, expressed by Sf9 insect cells , with GST labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
CTNNA1 Protein, Human (sf9, GST) is the recombinant human-derived CTNNA1, expressed by Sf9 insect cells , with GST labeled tag.
Background
CTNNA1 is a protein that associates with the cytoplasmic domain of various cadherins. Its binding to cadherins forms a complex linked to the actin filament network, which is crucial for the cell-adhesion properties of cadherins. CTNNA1 can interact with both E-cadherin and N-cadherin. Initially thought to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the connection between cadherins and the actin cytoskeleton at adherens junctions, later studies revealed that cortical actin is more dynamic than E-cadherin/catenin complexes, and CTNNA1 does not bind to F-actin within the complex, suggesting an alternative linkage mechanism between actin and adherens junction components. The homodimeric form of CTNNA1 may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for actin filament binding. It is also involved in the regulation of WWTR1/TAZ, YAP1, and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity) and may play a critical role in cell differentiation.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag GST
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Accession
P35221-1 (M1-I906)
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Gene ID1495
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Protein Length
Full Length of Isoform-1
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Synonyms
CTNNA1; Catenin (Cadherin-Associated Protein), Alpha 1, 102kDa; Catenin Alpha 1; Epididymis Secretory Sperm Binding Protein; Catenin Alpha-1; Cadherin-Associated Protein; CAP102; Alpha E-Catenin; Renal Carcinoma Antigen NY-REN-13; CTNNA1 Protein; Alpha-E-
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AA Sequence
MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDRTAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVASTKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEFKAMDSI
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Molecular Weight
Approximately 123 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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