GRB7 Protein, Human (GST)
GRB7 Protein, Human (GST) is the recombinant human-derived GRB7, expressed by E. coli , with GST labeled tag.
- Species: Human
- Source: E. coli
-
Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Technical Parameters
-
Product Properties
- Documentation
- Help & FAQs
Biological Activity
GRB7 Protein, Human (GST) is the recombinant human-derived GRB7, expressed by E. coli , with GST labeled tag.
GRB7 is an adapter protein that interacts with the cytoplasmic domains of numerous receptor kinases and modulates downstream signaling. It promotes the activation of downstream protein kinases, including STAT3, AKT1, MAPK1, and/or MAPK3, as well as the activation of HRAS. GRB7 plays a role in signal transduction in response to EGF and is involved in regulating cell proliferation and migration. Additionally, it contributes to the assembly and stability of RNA stress granules. When unphosphorylated, GRB7 binds to the 5'UTR of target mRNAs and represses their translation. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (by similarity).
Technical Parameters
-
Species Human
-
Source E. coli
-
Tag GST
-
Accession
Q14451-1 (M1-L532)
-
Gene ID2886
-
Protein Length
Full Length of Isoform-1
-
Synonyms
GRB7; GRB7 Adapter Protein; Growth Factor Receptor Bound Protein 7; B47; Growth Factor Receptor-Bound Protein 7; Growth Factor Receptor-Bound Protein 7 Isoform 1; Epidermal Growth Factor Receptor GRB-7; Growth Factor Receptor-Bound Protein 7 Isoform 2
-
AA Sequence
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL
-
Molecular Weight
Approximately 91 kDa, based on SDS-PAGE under reducing conditions.
-
Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
