MICA Protein, Human (HEK293, His-Avi)
MHC class I chain-related protein A (MICA) is a highly polymorphic major histocompatability complex class I chain-related protein A. MICA is expressed on the cell surface and is a ligand for the NKG2-D type II integral membrane protein receptor and functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells, MICA has been associated with susceptibility to psoriasis 1 and psoriatic arthritis. MICA Protein, Human (HEK293, His-Avi) is the recombinant human-derived MICA protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
Description
MHC class I chain-related protein A (MICA) is a highly polymorphic major histocompatability complex class I chain-related protein A. MICA is expressed on the cell surface and is a ligand for the NKG2-D type II integral membrane protein receptor and functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells, MICA has been associated with susceptibility to psoriasis 1 and psoriatic arthritis. MICA Protein, Human (HEK293, His-Avi) is the recombinant human-derived MICA protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
Background
MHC class I chain-related protein A (MICA) is a highly polymorphic major histocompatability complex class I chain-related protein A. MICA is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. MICA is a ligand for the NKG2-D type II integral membrane protein receptor and functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations of MICA have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma[1][2].
Technical Parameters
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Species Human
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Source HEK293
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Tag C-Avi;C-8*His
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Accession
Q96QC4 (E24-Q308)
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Molecular Construction
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N-term
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MICA (E24-Q308)
Accession # Q96QC4 -
8*His-Avi
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C-term
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Protein Length
Partial
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Synonyms
MICA; MHC Class I Related Chain A Isoform B1; MHC Class I Polypeptide-Related Sequence A; MHC Class I Related Chain A Isoform B2; PERB11.1; MHC Class I Related Chain A Isoform C; Major Histocompatibility Complex Class I Chain-Related Protein A; MHC Class
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AA Sequence
EPHSLRYNLTVLSWDGSVQSGFLAEVHLDGQPFLRYDRQKCRAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIKDQKEGLHSLQEIRVCEIHEDNSTRSSQHFYYDGELFLSQNLETEEWTVPQSSRAQTLAMNVRNFLKEDAMKTKTHYHAMHADCLQELRRYLESGVVLRRTVPPMVNVTRSEASEGNITVTCRASSFYPRNIILTWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICRGEEQRFTCYMEHSGNHSTHPVPSGKVLVLQSHWQ
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Predicted Molecular Mass
35.8 kDa
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Molecular Weight
Approximately 55-70 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
References
[1]. Jeevankumar S, et al. Association of MICA gene Exon-5 polymorphism in oral submucous fibrosis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2023 Jan;135(1):110-116. [Content Brief]
[2]. Tchacrome I, et al. Diseases association with the polymorphic major histocompatibility complex class I related chain a: MICA gene. Transpl Immunol. 2022 Dec;75:101665. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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