MICA - MHC class I polypeptide-related sequence A Gene

Also Known as MIC-A; PERB11.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 100507436

About MICA

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,400,711-31,415,315 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 407 orthologues and 22 paralogues. Ubiquitous expression in lung (RPKM 8.7), endometrium (RPKM 7.4) and 25 other tissues.

Summary

This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]

MICA Products (5)

mRNA	Protein	Name
NM_000247.3	NP_000238.1	MHC class I polypeptide-related sequence A isoform 1 (MICA*001) precursor
NM_001177519.3	NP_001170990.1	MHC class I polypeptide-related sequence A isoform 2 (MICA*00801) precursor
NM_001289152.2	NP_001276081.1	MHC class I polypeptide-related sequence A isoform 3 (MICA*00801)
NM_001289153.2	NP_001276082.1	MHC class I polypeptide-related sequence A isoform 3 (MICA*00801)
NM_001289154.2	NP_001276083.1	MHC class I polypeptide-related sequence A isoform 4 (MICA*00801)

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
NOT enables beta-2-microglobulin binding	IDA IDA: Inferred from direct assay	8901601	GOA
enables natural killer cell lectin-like receptor binding	IDA IDA: Inferred from direct assay	11491531	GOA
enables natural killer cell lectin-like receptor binding	IPI IPI: Inferred from physical interaction	10426993	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11323699	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	11777960	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	15995699	GOA
involved in T cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	10426993	GOA
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	11485740	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	11224526	GOA
involved in gamma-delta T cell activation	IDA IDA: Inferred from direct assay	9497295	GOA
involved in immune response to tumor cell	IDA IDA: Inferred from direct assay	10359807	GOA
involved in natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	10426993	GOA
involved in negative regulation of natural killer cell activation	IDA IDA: Inferred from direct assay	20068167	GOA
involved in negative regulation of natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	20068167	GOA
involved in response to heat	IDA IDA: Inferred from direct assay	8901601	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	8901601	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	18676862	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	10363723	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18676862	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
MHC class I polypeptide-related sequence A	HLA class I antigen

MICA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MICA	Q29983	LGALS3	Homo sapiens	P17931	Crosslink	21712812

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MICA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70157	MICA Protein, Human (HEK293, His)	AAH16929.1 (E24-Q308)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70579	MICA Protein, Human (HEK293, Fc)	AAH16929.1 (E24-Q308)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77997	MICA Protein, Human (HEK293, His-Avi)	Q96QC4 (E24-Q308)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77998	MICA Protein, Human (Biotinylated, HEK293, His-Avi)	Q96QC4 (E24-Q308)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P700790	MICA Protein, Human (HEK293, mFc)	NP_001276081.1 (R105-S200)	≥ 95%, as determined by reducing SDS-PAGE.

MICA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81719	MICA Antibody (YA1464)	WB, IP, FC	Human
HY-P83760	MICA+MICB Antibody (YA3560)	WB, IP, FC	Human

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D0916	Thiazole orange dimer YOYO 1		97.00%	Unkown
HY-155311	NKG2D-IN-1	Inhibitor	99.84%	Unkown
HY-155312	NKG2D-IN-2	Inhibitor	/	Unkown
HY-101780A	Tinostamustine hydrochloride	Inhibitor	/	Unkown
HY-RS08424	MICA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-151782	H-(Gly)3-Lys(N3)-OH		/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992266	Anti-MICA/B Antibody (7C6)		/	Unkown
HY-P992391	IPH4301		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MICA	RGD	RGD:1311714