1. Recombinant Proteins
  2. TNF-alpha/TNFSF2 Protein, Human (P.pastoris)

TNF-alpha/TNFSF2 Protein, Human (P.pastoris)

Cat. No.: HY-P7058A
Handling Instructions

TNF-alpha/TNFSF2 Protein, Human (P.pastoris) is a strong pro-inflammatory cytokine, exhibits high efficacy and tumor cell targeting capability, with low toxicity effects on healthy cells.

For research use only. We do not sell to patients.

Protein Expression Service

Recombinant Proteins-MedChemExpress
Size Price Stock Quantity
10 μg $150 In-stock
Estimated Time of Arrival: December 31
50 μg $240 In-stock
Estimated Time of Arrival: December 31
100 μg   Get quote  
250 μg   Get quote  

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  • Technical Parameters

  • Properties

  • Documentation

rHuTNF-α/TNFSF2; TNF-alpha; Cachectin; DIF; TNFA; Differentiation-inducing factor



P. pastoris


P01375 (V77-L233)

Gene ID


Molecular Weight

Approximately 17.4 kDa

AA Sequence


Biological Activity
The ED50 is <0.08 ng/mL as measured by L-929 mouse fibrosarcoma cells, corresponding to a specific activity of >1.25 × 107 units/mg.

Lyophilized powder.


Lyophilized after extensive dialysis against PBS.

Endotoxin Level

<1 EU/μg, determined by LAL method.


It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.


Room temperature in continental US; may vary elsewhere.


Tumor necrosis factor α (TNF-α, also known as cachectin) is a strong pro-inflammatory cytokine playing an important role in the immune system during inflammation, cell proliferation, differentiation and apoptosis. TNF-α is type II transmembrane protein that can be expressed in both membrane-bound and secreted forms. Receptors for TNF-a are part of TNF receptor (TNFR) superfamily, with characteristic intracellular segment, a transmembrane domain, and an extracellular ligand-binding domain. They are type I transmembrane glycoproteins characterized by a cysteinerich motif (up to 40 aminoacids) repeated 2-6 times in the extracellular N-terminal domain[1]. Tumor necrosis factor-α (TNF-α) is a pleiotropic factor exhibiting antitumor effects, alters endothelial barrier function, reduces tumor interstitial pressure and mediates immune responses. TNF-α is associated with a number of cell signalling events, associated with cell necrosis and apoptosis, and is important for resistance to infection and cancer[2]

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TNF-alpha/TNFSF2 Protein, Human (P.pastoris)
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