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Art. -Nr.: HY-187116

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Rhodamine B ethyl ester

Rhodamine B ethyl ester is a hydrophilic cationic derivative of Rhodamine B (HY-Y0016), belonging to non-selective cytotoxic agents and transporters. Rhodamine B ethyl ester exhibits broad-spectrum in vitro cytotoxicity and exerts cytotoxic effects on human tumor cells. Rhodamine B ethyl ester binds effectively to lipid membranes, undergoes voltage-dependent transport across planar bilayer phosphatidylcholine membranes, and its transport can be determined by current relaxation after voltage jump. Rhodamine B ethyl ester can be used in research related to cancers such as epithelioid melanoma and colorectal adenocarcinoma.

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CAS. Nr.: 2390-63-8
Formel: C₃₀H₃₅ClN₂O₃
Molecular Weight:507.06

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Rhodamine B ethyl ester Chemical Structure

CAS. Nr.: 2390-63-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	EC50	0.38 μM	Cytotoxicity against human epithelial melanoma A375 cells assessed by Sulforhodamine B (SRB) assay after 72 h incubation, averaged from three independent experiments performed in triplicate. Cytotoxicity against human epithelial melanoma A375 cells assessed by Sulforhodamine B (SRB) assay after 72 h incubation, averaged from three independent experiments performed in triplicate.	s00044-020-02591-8
HT-29	EC50	0.41 μM	Cytotoxicity against human colorectal adenocarcinoma HT29 cells assessed by Sulforhodamine B (SRB) assay after 72 h incubation, averaged from three independent experiments performed in triplicate. Cytotoxicity against human colorectal adenocarcinoma HT29 cells assessed by Sulforhodamine B (SRB) assay after 72 h incubation, averaged from three independent experiments performed in triplicate.	s00044-020-02591-8
MCF7	EC50	0.23 μM	Cytotoxicity against human breast adenocarcinoma MCF-7 cells assessed by Sulforhodamine B (SRB) assay after 72 h incubation, averaged from three independent experiments performed in triplicate. Cytotoxicity against human breast adenocarcinoma MCF-7 cells assessed by Sulforhodamine B (SRB) assay after 72 h incubation, averaged from three independent experiments performed in triplicate.	s00044-020-02591-8
A2780	EC50	0.21 μM	Cytotoxicity against human ovarian carcinoma A2780 cells assessed by Sulforhodamine B (SRB) assay after 72 h incubation, averaged from three independent experiments performed in triplicate. Cytotoxicity against human ovarian carcinoma A2780 cells assessed by Sulforhodamine B (SRB) assay after 72 h incubation, averaged from three independent experiments performed in triplicate.	s00044-020-02591-8
FaDu	EC50	0.30 μM	Cytotoxicity against human squamous cell carcinoma FaDu cells assessed by Sulforhodamine B (SRB) assay after 72 h incubation, averaged from three independent experiments performed in triplicate. Cytotoxicity against human squamous cell carcinoma FaDu cells assessed by Sulforhodamine B (SRB) assay after 72 h incubation, averaged from three independent experiments performed in triplicate.	s00044-020-02591-8
NIH3T3	EC50	0.96 μM	Cytotoxicity against nonmalignant mouse NIH 3T3 fibroblasts assessed by Sulforhodamine B (SRB) assay after 72 h incubation, averaged from three independent experiments performed in triplicate. Cytotoxicity against nonmalignant mouse NIH 3T3 fibroblasts assessed by Sulforhodamine B (SRB) assay after 72 h incubation, averaged from three independent experiments performed in triplicate.	s00044-020-02591-8

In Vitro

Anti-cancerOthers

Anti-cancer

Rhodamine B ethyl ester (compound 1) exhibits cytotoxicity against human tumor cell lines A375, HT29, MCF-7, A2780 and FaDu, as well as non-malignant NIH 3T3 mouse fibroblasts, with EC₅₀ values ranging from 0.21 μM (A2780) to 0.96 μM (NIH 3T3), and shows low selectivity^[1].

Others

Rhodamine B ethyl ester (C₂RB) (0.2 μM) can translocate across DPhytanylPC planar bilayers, with a translocation rate constant of 1.1 s⁻¹ and a characteristic relaxation time of 0.12 s under a 100 mV voltage jump^[2].
Rhodamine B ethyl ester shows slower translocation rates in ester-type planar bilayer membranes (DPhPC, DOPC, DEPC) than in ether-linked DPhytanylPC bilayers, and its characteristic relaxation time rises as the fatty acid chains of membrane lipids get longer under a 100 mV voltage jump^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS. Nr. 2390-63-8
Molecular Weight 507.06
Formel C₃₀H₃₅ClN₂O₃
SMILES

O=C(C1=C(C2=C3C=CC(N(CC)CC)=CC3=[O+]C4=C2C=CC(N(CC)CC)=C4)C=CC=C1)OCC.[Cl-]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Serbian I, et al. Ester and amide derivatives of rhodamine B exert cytotoxic effects on different human tumor cell lines. Medicinal Chemistry Research, 2020, 29: 1655‑1661.

[2]. Rokitskaya TI, et al. Effect of Alkyl Chain Length on Translocation of Rhodamine B n-Alkyl Esters across Lipid Membranes. Biophysical journal. 2018 Aug 07;115(3):514-521.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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