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Art. -Nr.: HY-N10392

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(S)-Erypoegin K

(S)-Erypoegin K is a potent anticancer agent. (S)-Erypoegin K shows potent anti-proliferative activity against HL-60 cells. (S)-Erypoegin K induces apoptosis.

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CAS. Nr.: 2055053-90-0
Formel: C₂₀H₁₈O₆
Molecular Weight:354.35

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

(S)-Erypoegin K Chemical Structure

CAS. Nr.: 2055053-90-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

(S)-Erypoegin K is a potent anticancer agent. (S)-Erypoegin K shows potent anti-proliferative activity against HL-60 cells. (S)-Erypoegin K induces apoptosis^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
GCIY	IC₅₀	0.27 μM Compound: (S)-EpK	Cytotoxicity against human GCIY cells assessed as reduction in cell viability measured after 48 hrs by MTS/CellTiter96 aqueous one solution cell proliferation assay Cytotoxicity against human GCIY cells assessed as reduction in cell viability measured after 48 hrs by MTS/CellTiter96 aqueous one solution cell proliferation assay	[PMID: 33341500]
HL-60	IC₅₀	90 nM Compound: (S)-EpK	Antiproliferative activity against human HL60 cells assessed as inhibition of cell viability incubated for 48 hrs by MTS assay Antiproliferative activity against human HL60 cells assessed as inhibition of cell viability incubated for 48 hrs by MTS assay	[PMID: 32299660]
MKN-1	IC₅₀	0.327 μM Compound: (S)-EpK	Cytotoxicity against human MKN-1 cells assessed as reduction in cell viability measured after 48 hrs by MTS/CellTiter96 aqueous one solution cell proliferation assay Cytotoxicity against human MKN-1 cells assessed as reduction in cell viability measured after 48 hrs by MTS/CellTiter96 aqueous one solution cell proliferation assay	[PMID: 33341500]

In Vitro

(S)-Erypoegin K (0-1 µM; 48 h)shows potent anti-proliferative activity against HL-60 cells with an IC₅₀ of 90 nM^[1].
(S)-Erypoegin K (0.1, 0.5 µM; 24 h) induces marked activation of caspase-3 and −9 in HL-60 cells in a time- and dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2055053-90-0
Molecular Weight 354.35
Formel C₂₀H₁₈O₆
SMILES

CC(O)([C@@H]1CC2=C(O1)C=C(C3=C2OC=C(C3=O)C4=CC=C(C=C4)O)O)C
Structure Classification
- Flavonoids
- Isoflavones
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Hikita K, et al. Induction of enantio-selective apoptosis in human leukemia HL-60 cells by (S)-erypoegin K, an isoflavone isolated from Erythrina poeppigiana. Bioorg Med Chem. 2020 Jun 1;28(11):115490. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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