2. PROTAC
  3. Ligands for E3 Ligase
  4. (S,R,S)-AHPC-PEG2-SH

(S,R,S)-AHPC-PEG2-SH is a VHL ligand based on (S,R,S)-AHPC that recruits von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-PEG2-SH can be linked to a target protein ligand via a linker to form a PROTACs.

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(S,R,S)-AHPC-PEG2-SH

(S,R,S)-AHPC-PEG2-SH Chemical Structure

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(S,R,S)-AHPC-PEG2-SH Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

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Description

(S,R,S)-AHPC-PEG2-SH is a VHL ligand based on (S,R,S)-AHPC that recruits von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-PEG2-SH can be linked to a target protein ligand via a linker to form a PROTACs.

IC50 & Target

VHL

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S,R,S)-AHPC-PEG2-SH Related Antibodies
Molecular Weight

606.80

Formula

C29H42N4O6S2
SMILES

CC1=C(SC=N1)C2=CC=C(C=C2)CNC(C3C[C@H](CN3C(C(C(C)(C)C)NC(CCOCCOCCS)=O)=O)O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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(S,R,S)-AHPC-PEG2-SH Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-PEG2-SHLigands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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