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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
328 Results for "
pathogenicity
" in MedChemExpress (MCE) Product Catalog:
Products (328)
328 Results for "pathogenicity" in MCE Product Catalog:
Cat. No.: HY-147412D
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FAM labled Ultevursen sodiumis a FAM labled Ultevursen sodium (HY-147412A). Ultevursen sodium (QR-421a) is a splice-modulating antisense oligonucleotide targeting exon 13 of the USH2A gene, which restores the functional expression of Usherin protein by inducing exon skipping. Ultevursen sodium binds to USH2A pre-mRNA and modulates the splicing process to specifically skip exon 13 carrying the pathogenic mutation c.2299delG, generating an in-frame transcript and a truncated yet functionally normal protein. Ultevursen sodium exhibits concentration-dependent exon skipping activity in human cells and retinal organoid models, and restores Usherin expression and retinal function in zebrafish and gene-edited mouse models. Ultevursen sodium can be used for related research on type 2 Usher syndrome and non-syndromic retinitis pigmentosa .
Cat. No.: HY-147412E
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Cy3 labled Ultevursen sodium is a Cy3 labled Ultevursen sodium (HY-147412A). Ultevursen sodium (QR-421a) is a splice-modulating antisense oligonucleotide targeting exon 13 of the USH2A gene, which restores the functional expression of Usherin protein by inducing exon skipping. Ultevursen sodium binds to USH2A pre-mRNA and modulates the splicing process to specifically skip exon 13 carrying the pathogenic mutation c.2299delG, generating an in-frame transcript and a truncated yet functionally normal protein. Ultevursen sodium exhibits concentration-dependent exon skipping activity in human cells and retinal organoid models, and restores Usherin expression and retinal function in zebrafish and gene-edited mouse models. Ultevursen sodium can be used for related research on type 2 Usher syndrome and non-syndromic retinitis pigmentosa .
Cat. No.: HY-182788
CAS No.: 3113741-59-3
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Multitarget AD-IN-7 is an orally active multi-target anti-AD compound. Multitarget AD-IN-7 exhibits inhibitory activity against GSK-3β and GSK-3α (IC50 = 0.66, 0.83 nM). Multitarget AD-IN-7 upregulates the expression of p-GSK-3β-Ser9, inhibits the phosphorylation of tau-Ser396, targets Aβ1-42, chelates pathogenic metal ions, scavenges ABTS•+, upregulates the expression of β-catenin and neurogenesis biomarkers, and promotes neurite outgrowth. Multitarget AD-IN-7 improves motor ability in Alzheimer's disease zebrafish. Multitarget AD-IN-7 is applicable to research related to Alzheimer's disease .
Cat. No.: HY-N18656
CAS No.: 90131-48-9
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N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)) is a rate-limiting enzyme in bacteria metabolism that catalyzes the reversible aldol cleavage of sialic acid, and it regulates the overall metabolism of the bacterial sialic acid catabolic pathway. N-Acetylneuraminate lyase (CgNal) catalyzes the reversible condensation reaction of pyruvate and N-acetyl-d-mannosamine (ManNAc) to produce sialic acid N-acetylneuraminic acid (Neu5Ac). The protein expression of N-Acetylneuraminate lyase is downregulated at the translational level under the regulation of methyl methanesulfonate, and this change significantly impairs the adhesion and invasion abilities of bacteria to eukaryotic cells. N-Acetylneuraminate lyase is a key virulence-related protein in various pathogenic bacteria and is considered an antibiotic drug target. N-Acetylneuraminate lyase (CgNal) can be used in studies of invasive (extraintestinal) infectious diseases, Crohn's disease, and methicillin-resistant Staphylococcus aureus infections .
Cat. No.: HY-L072
58 compounds
Exosomes are small membrane vesicles of endocytic origin that are secreted by most cells in culture. Exosomes contain nucleic acids, proteins, lipids, amino acids, and metabolites, etc. Their diverse constituents can reflect their cell of origin. Exosomes are associated with immune responses, viral pathogenicity, pregnancy, cardiovascular diseases, central nervous system-related diseases, and cancer progression. Proteins, metabolites, and nucleic acids delivered by exosomes into recipient cells effectively alter their biological response. Such exosome-mediated responses can be disease promoting or restraining.
The biology of exosomes in disease is still emerging, and the number of studies addressing their utility in the diagnosis and treatment of various pathologies has increased substantially. MCE supplies a unique collection of 58 compounds with the activity of inhibiting or stimulating exsomes secretion/biosynthesis. MCE Exosomes Compound Library is a useful tool for exsomes research.
Cat. No.: HY-L172
150 compounds
Immunity refers to the ability of the body to resist the invasion of pathogenic microorganisms and resist a variety of diseases. Immunocompromised will inevitably lead to a series of diseases. Immunopotentiator are a class of compounds that enhance immune function and induce immune response. Immunopotentiator can activate the proliferation and differentiation of one or more kinds of immune active cells in the body, promote the secretion of lymphocytes, and then enhance the immune function of the body. Immunopotentiator are mainly used in the treatment of tumors, infectious diseases and immunodeficiency diseases. In addition, immunopotentiator are often used as adjuvants in combination with vaccine antigens to enhance the immunogenicity of vaccines.
MCE designs a unique collection of 150 compounds with definite or potential Immunopotentiating effect, mainly targeting the NOD-like Receptor (NLR), Toll-like Receptor (TLR), NF-κB, etc. It is an effective tool for development and research of anti-cancer, anti-infectious diseases and anti-immunodeficiency diseases compounds.
Cat. No.: HY-W558657A
CAS No.: 14990-09-1
Tert-Butyl cinnamate is a tert-butyl cinnamate with antifungal activity and comonomer function, which exhibits an average inhibition rate of 73.0% against phytopathogenic fungi at a concentration of 0.5 mM. Tert-Butyl cinnamate can be used in studies related to phytopathogenic fungal infections .
Cat. No.: HY-W743904
CAS No.: 84-31-1
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Cat. No.: HY-130323
CAS No.: 67597-26-6
13-HPOT is a linolenic acid hydroperoxide and an antibacterial agent. 13-HPOT interacts with lipid representatives of bacterial inner membranes. 13-HPOT exerts dose-dependent in vitro antibacterial activity against Pectobacterium carotovorum, Pseudomonas syringae pv. syringae DC3000, and Xanthomonas translucens pv. translucens .
Cat. No.: HY-N7368
CAS No.: 55366-56-8
Category:
Flavonols other families Flavonoids Neurological Disease Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-P10785
CAS No.: 83785-07-3
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Cat. No.: HY-L137
124 compounds
Targeted protein degradation(TPD) is a novel and promising approach to new drug discovery and development. It shows great potential for treating diseases with “undruggable” pathogenic protein targets and for overcoming drug resistance. Molecular glues and PROTACs are both targeted protein degraders that have attracted the most attention.
Molecular glues are small molecular degraders that mainly induce novel interaction between an E3 ligase and a target protein to form a ternary complex, leading to protein ubiquitination and subsequent proteasome degradation. Compared with PROTACs, molecular glues generally possess more favorable drug-like properties, such as lower MW, higher cell permeability, and better oral absorption. Molecular glues are emerging as a promising new therapeutic strategy.
MCE supplies a unique collection of 124 molecular glues which target various proteins. MCE Molecular Glue Compound Library is a useful tool to conduct scientific research and disease mechanism study.
Cat. No.: HY-L224
2,478 compounds
Diarrhea is a disease symptom, and the pathophysiologic basis of diarrhea is a disturbance in intestinal water and electrolyte balance, which may be due to increased secretion of osmotically active electrolytes (secretory diarrhea) or increased intake of osmotically active substances (osmotic diarrhea). Food poisoning, pathogenic bacterial infections, and intestinal-related diseases can all contribute to the development of diarrhea. Traditional Chinese Medicine (TCM) considers diarrhea to be a symptom of an imbalance in the body's systems, particularly related to the functions of the spleen and stomach. Spleen qi deficiency, dampness-heat, liver and spleen disharmony are closely related to diarrhea. Many types of Chinese herbs regulate the function of diarrhea, such as: Dysosmae Verspiellis Rhixoma Et Radix, Ginkgo Semen, Forsythiae Fructus, and Campsis Flos.
MCE can provide 2,478 active monomers that can be obtained from TCM herbs with diarrhea-regulating functions, which can be applied to drug development and disease mechanism research.
Cat. No.: HY-184308
CAS No.: 3123321-73-0
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Antifungal agent-165 is an antifungal agent with in vitro activity against Rhizoctonia solani. Antifungal agent-165 inhibits catalase (CAT) activity, drives intracellular ROS accumulation, and induces oxidative damage. Antifungal agent-165 disrupts fungal hyphal morphology, compromises cell membrane integrity, and triggers cellular content leakage in Rhizoctonia solani. Antifungal agent-165 can be used for the research of potato black scurf disease .
Cat. No.: HY-N19641
CAS No.: 244182-09-0
Synonyms: Dichlorodiaportin
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Cat. No.: HY-N19907
CAS No.: 1374428-43-9
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Lactitol (D-Lactitol) is a non-absorbable disaccharide and Bacterial regulator. Lactitol reduces the populations of Bacteroides, Clostridium, coliforms and Eubacterium, while increasing the populations of Lactobacillus and Streptococcus. Lactitol can be used in the research of portosystemic encephalopathy and chronic constipation .
Cat. No.: HY-W011117
CAS No.: 112398-08-0
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Danofloxacin is an orally active quinolone antibiotic. Danofloxacin targets bacterial DNA gyrase and inhibits bacterial DNA replication, transcription and growth. Danofloxacin can be used for various bacterial infections caused by Escherichia coli, Mycoplasma and other pathogens .
Cat. No.: HY-N7368R
CAS No.: 55366-56-8
Category:
Flavonols other families Flavonoids Phenols Polyphenols Plants
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
