9027-60-5
Chemical Structure
N-Acetylneuraminate lyase (CgNal)
Synonym(s): Sialic acid aldolase (CgNal)
- CAS No.: 9027-60-5
- Formula:N/A
- Molecular Weight:N/A
SMILES: [N-Acetylneuraminate lyase (CgNal)]
Biological Activity: N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)) is a rate-limiting enzyme in bacteria metabolism that catalyzes the reversible aldol cleavage of sialic acid, and it regulates the overall metabolism of the bacterial sialic acid catabolic pathway. N-Acetylneuraminate lyase (CgNal) catalyzes the reversible condensation reaction of pyruvate and N-acetyl-d-mannosamine (ManNAc) to produce sialic acid N-acetylneuraminic acid (Neu5Ac). The protein expression of N-Acetylneuraminate lyase is downregulated at the translational level under the regulation of methyl methanesulfonate, and this change significantly impairs the adhesion and invasion abilities of bacteria to eukaryotic cells. N-Acetylneuraminate lyase is a key virulence-related protein in various pathogenic bacteria and is considered an antibiotic drug target. N-Acetylneuraminate lyase (CgNal) can be used in studies of invasive (extraintestinal) infectious diseases, Crohn's disease, and methicillin-resistant Staphylococcus aureus infections[1][2][3][4].
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N-Acetylneuraminate lyase (CgNal) | N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)) is a rate-limiting enzyme in bacteria metabolism that catalyzes the reversible aldol cleavage of sialic acid, and it regulates the overall metabolism of the bacterial sialic acid catabolic pathway. N-Acetylneuraminate lyase (CgNal) catalyzes the reversible condensation reaction of pyruvate and N-acetyl-d-mannosamine (ManNAc) to produce sialic acid N-acetylneuraminic acid (Neu5Ac). The protein expression of N-Acetylneuraminate lyase is downregulated at the translational level under the regulation of methyl methanesulfonate, and this change significantly impairs the adhesion and invasion abilities of bacteria to eukaryotic cells. N-Acetylneuraminate lyase is a key virulence-related protein in various pathogenic bacteria and is considered an antibiotic drug target. N-Acetylneuraminate lyase (CgNal) can be used in studies of invasive (extraintestinal) infectious diseases, Crohn's disease, and methicillin-resistant Staphylococcus aureus infections. | |||||||||||||||||||||
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References
- [1]. Vimr ER, et al. Diversity of microbial sialic acid metabolism. Microbiology and molecular biology reviews : MMBR. 2004 Mar;68(1):132-53. [Content Brief]
- [2]. Di Pasquale P, et al. Exposure of E. coli to DNA-Methylating Agents Impairs Biofilm Formation and Invasion of Eukaryotic Cells via Down Regulation of the N-Acetylneuraminate Lyase NanA. Frontiers in microbiology. 2016;7:147. [Content Brief]
- [3]. North RA, et al. Structure and inhibition of N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus. FEBS letters. 2016 Dec;590(23):4414-4428. [Content Brief]
- [4]. Li Y, et al. Pasteurella multocida sialic acid aldolase: a promising biocatalyst. Applied microbiology and biotechnology. 2008 Jul;79(6):963-70. [Content Brief]
