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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3417 Results for "
mSWI/SNF complex
" in MedChemExpress (MCE) Product Catalog:
Products (3417)
3417 Results for "mSWI/SNF complex" in MCE Product Catalog:
Cat. No.: HY-P83718
Synonyms: FLJ25321 antibody;
HC5 antibody;
KIAA1838 antibody;
Macropain subunit C5 antibody;
Multicatalytic endopeptidase complex subunit C5 antibody;
Proteasome (prosome macropain) subunit beta type 1 antibody;
Proteasome beta 1 subunit antibody;
Proteasome component C5 antibody;
Proteasome gamma chain antibody;
Proteasome subunit beta type 1 antibody;
Proteasome subunit beta type-1 antibody;
Proteasome subunit HC5 antibody;
PSB1_HUMAN antibody;
PSC5 antibody;
PSMB 1 antibody;
PSMB1 antibody
Cat. No.: HY-P85514
Synonyms: Basic transcription factor 2 62 kDa subunit; Basic transcription factor 62 kDa subunit; BTF 2; BTF2; BTF2 p62; General transcription factor IIH polypeptide 1; General transcription factor IIH subunit 1; General transcription factor IIH, polypeptide 1, 62kDa; gtf2h1; TF2H1; TF2H1_HUMAN; TFB1; TFIIH; TFIIH basal transcription factor complex p62 subunit.
Cat. No.: HY-P811903
Synonyms: RMND5A; Required For Meiotic Nuclear Division 5 Homolog A; P44CTLH; GID2A; RMD5; GID2; E3 Ubiquitin-Protein Transferase RMND5A; 44-KD Protein Coding For CTLH Motif; GID complex Subunit 2 Homolog A; Protein RMD5 Homolog A; FLJ13910; Required For Meiotic Nuclear Division 5 Homolog A (S. Cerevisiae); C-Terminal To LisH Motif, 44 KDa; EC 2.3.2.27; CTLH
Cat. No.: HY-131384
CAS No.: 34262-64-1
Synonyms: 8,11,14-Icosatriynoic acid
Cat. No.: HY-170524
CAS No.: 3052313-73-9
연구분야:
TDI-015051 is a highly selective, orally active antiviral agent that targets the coronavirus NSP14 guanine-N7 methyltransferase. TDI-015051 binds to substrates in a non-competitive manner and forms a stable ternary complex, precisely blocking the capping and methylation processes of viral mRNA. TDI-015051 potently inhibits a variety of coronaviruses (including SARS-CoV-2 and MERS). By impairing viral replication and translation and inducing a moderate type I interferon-mediated immune response, it significantly reduces pulmonary viral load and exhibits a synergistic effect with Nirmatrelvir (HY-138687). In addition, TDI-015051 does not inhibit non-coronavirus methyltransferases, and the drug-resistant mutations it induces impair viral fitness, demonstrating excellent antiviral properties and safety. TDI-015051 can be used for research on COVID-19 and the replication mechanism of coronaviruses .The IC50 values of TDI-015051 against SARS-CoV-2, α-hCoV-NL63, α-hCoV-229E, β-hCoV-MERS are 0.15 nM, 1.7 nM, 2.6 nM and 3.6 nM, respectively, and the Ka value against SARS-CoV-2 is 0.061 nM .
Cat. No.: HY-170820
CAS No.: 3006788-11-7
Target:
Molecular Glues Eukaryotic Release Factor (eRF) Bcl-2 Family CDK EGFR HSP Androgen Receptor c-Myc
연구분야:
XYD049 is a CRBN-based molecular glue degrader targeting GSPT1, with a DC50 of 19 nM. XYD049 mediates the formation of a ternary complex between CRBN and GSPT1, thereby triggering CRBN- and proteasome-dependent degradation of GSPT1. By degrading GSPT1, XYD049 downregulates castration-resistant prostate cancer (CRPC)-related oncogenes, including BCL2, CDK2, E2F3, EGFR, HSP90B1, TMPRSS2, AR, AR-V7, PSA and c-Myc. XYD049 inhibits cancer cell growth and suppresses tumor growth in mice. XYD049 can be used for research on castration-resistant prostate cancer. XYD049 consists of a linker (black part) NH2-C5-NH-Boc (HY-W004710), a CRBN-based E3 ligase ligand (blue part) Thalidomide 4-fluoride (HY-41547), and a target protein ligand (red part) GSPT1 ligand-1 (HY-170821), among which the E3 ligase ligand plus linker forms the conjugate E3 Ligase Ligand-linker Conjugate 158 (HY-170822) .
Cat. No.: HY-174379
NTLiverTac PDE6D degrader-1 is a PDE6D NTLiverTac degrader with a DC50 of 4.09 μM. NTLiverTac PDE6D degrader-1 is formed by conjugating a PDE6D PROTAC degrader with the NTCP ligand Cholic acid (HY-N0324). NTLiverTac PDE6D degrader-1 triggers the ubiquitin-proteasome system-mediated degradation process by forming a complex with PDE6D and MDM2, inducing proteasome-dependent and NTCP-dependent degradation. NTLiverTac PDE6D degrader-1 inhibits PDE6D-dependent KRAS trafficking and suppresses KRAS-related oncogenic signaling cascades. NTLiverTac PDE6D degrader-1 inhibits the activation of the PI3K/AKT/mTOR signaling pathway and induces cellular Apoptosis. NTLiverTac PDE6D degrader-1 enters cancer cells via NTCP-mediated endocytosis. NTLiverTac PDE6D degrader-1 can be used in the research of hepatoblastoma (MDM2 ligand: (4R,5S)-Nutlin carboxylic acid (HY-128836); NTCP ligand: Cholic acid (HY-N0324); PDE6D ligand: Sorafenib (HY-10201)) .
Cat. No.: HY-W657887
CAS No.: 154866-92-9
Target:
Histone Methyltransferase GSK-3 Tau Protein Amyloid-β Glucocorticoid Receptor Androgen Receptor Adrenergic Receptor
연구분야:
GSK-3β/G9a-IN-1 (Compound T2) is an orally active, selective, blood-brain-barrier permeable, competitive G9a (substrate-competitive, IC50: 1.1 μM) and GSK-3β (ATP competitive, IC50: 0.8 μM) inhibitor. GSK-3β/G9a-IN-1 is a potent H3K9me2 inhibitor that reshapes chromatin landscape. GSK-3β/G9a-IN-1 lowers tau phosphorylation, reduces Aβ aggregation. GSK-3β/G9a-IN-1 displays inhibition toward glucocorticoid receptor, androgen receptor, and alpha-2A adrenergic receptor. GSK-3β/G9a-IN-1 also upregulates SAGA complex members such as Eny2 and Sgf29. GSK-3β/G9a-IN-1 markedly improves memory, restores social behaviors, and increases synaptic complexity in late-onset Alzheimer’s disease .
Cat. No.: HY-P85527
Synonyms: BRCA1/BRCA2 containing complex, subunit 5; BRCC 5; BRCC5; DNA repair protein RAD51 homolog 1; DNA repair protein rhp51; HRAD51; HsRad51; HsT16930; MRMV2; Rad 51; RAD51; RAD51 homolog; RecA homolog, E. coli; S. cerevisiae; RAD51 homolog A; RAD51 homolog; RAD51 recombinase; RAD51, S. cerevisiae, homolog of; RAD51_HUMAN; RAD51A; RECA; RecA like protein; RecA, E. coli, homolog of; Recombination protein A.
Cat. No.: HY-P86959
Synonyms: Activator recruited cofactor 240 kDa component antibody; Activator-recruited cofactor 240 kDa component antibody; ARC240 antibody; CAG repeat protein 45 antibody; CAGH45 antibody; HOPA antibody; KIAA0192 antibody; MED12 antibody; MED12_HUMAN antibody; Mediator complex subunit 12 antibody; Activator recruited cofactor 240 kDa component antibody; Activator-recruited cofactor 240 kDa component antibody; ARC240 antibody; CAG repeat protein 45 antibody; CAGH45 antibody; HOPA antibody; KIAA0192 antibody
Cat. No.: HY-P7S1354
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: S100A9; 60B8AG; Prev. CAGB; CGLB; Prev. CFAG; MIF; MRP-14; NIF; MRP14; Protein S100-A9; P14; Calgranulin B; Migration Inhibitory Factor-Related Protein 14; S100 Calcium-Binding Protein A9 (Calgranulin B); Leukocyte L1 complex Heavy Chain; S100 Calcium-Binding Protein A9; Calprotectin L1H Subunit; Calgranulin-B; S100-A9; L1AG; MAC387; S100 Calcium Binding Protein A9; LIAG
Species:
Rat
Source:
E. coli
Cat. No.: HY-P811903A
Synonyms: RMND5A; Required For Meiotic Nuclear Division 5 Homolog A; P44CTLH; GID2A; RMD5; GID2; E3 Ubiquitin-Protein Transferase RMND5A; 44-KD Protein Coding For CTLH Motif; GID complex Subunit 2 Homolog A; Protein RMD5 Homolog A; FLJ13910; Required For Meiotic Nuclear Division 5 Homolog A (S. Cerevisiae); C-Terminal To LisH Motif, 44 KDa; EC 2.3.2.27; CTLH
Cat. No.: HY-128795
CAS No.: 2095304-61-1
KH176m is the major active metabolite of KH176 (HY-121577). KH176m is a microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor that can cross the blood-brain barrier, with an IC50 of 0.16 µM against mouse mPGES-1 and 1.51 µM against human mPGES-1. KH176m blocks LPS- or IL-1β-induced PGE2 production, scavenges ROS, inhibits lipid peroxidation, accelerates NADPH consumption, suppresses the growth of prostate cancer spheroids, reduces the CD44 + CD24 − prostate cancer stem cell population, and protects fibroblasts with oxidative phosphorylation defects from redox stress-induced death. KH176m can be used in research related to mitochondrial diseases, inflammatory pain, inflammatory neurological diseases, inflammatory cancers, and prostate cancer .
Target:
연구분야:
I-XW-053 is a specific anti-HIV-1 capsid inhibitor (IC50=164.2 μM). By binding to the CA NTD-NTD hexamerization interface and the R173 region of CTD (Kd=66.3 μM), I-XW-053 disrupts capsid function and reduces polymerization levels. I-XW-053 effectively blocks HIV-1 uncoating, inhibits reverse transcription and early replication, and exhibits broad-spectrum activity against primary HIV-1 isolates in peripheral blood mononuclear cells. I-XW-053 can be widely used in studies related to HIV-1 infection .
Cat. No.: HY-186271
CAS No.: 2148927-98-2
Target:
연구분야:
TLR4 agonist-2 is a TLR4 agonist with EC50 values of 0.82 μM and 0.43 μM for mTLR4 and hTLR4, respectively. TLR4 agonist-2 induces the production of TLR4-dependent cytokines and chemokines. TLR4 agonist-2 can be used for immunological research .
Cat. No.: HY-P80984
Synonyms: CK-5; CK5; Cytokeratin-5; Cytokeratin5; DDD; DDD1; EBS2; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K2C5_HUMAN; K5; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); Keratin 5; Keratin ; keratin complex 2, basic, gene 5; keratin, type II cytoskeletal 5 ; Keratin-5; Keratin5; KRT 5; Krt5; KRT5A; type II cytoskeletal 5 ; Type-II keratin Kb5;
Cat. No.: HY-P83701
Synonyms: HLA class I histocompatibility antigen E alpha chain antibody;
EA1.2 antibody;
EA2.1 antibody;
HLA 6.2 antibody;
HLA class I histocompatibility antigen alpha chain E antibody;
HLA class I histocompatibility antigen E alpha chain precursor antibody;
HLA class I histocompatibility antigen E alpha chain precursor antibody;
HLA6.2 antibody;
HLAE antibody;
Lymphocyte antigen antibody;
Major histocompatibility complex class I E antibody;
MHC antibody;
MHC class I antigen E antibody;
MHC HLA E alpha 1 antibody;
MHC HLA E alpha 2.1 antibody;
QA1 antibody;
Cat. No.: HY-P812022
Synonyms: MTREX; Mtr4 Exosome RNA Helicase; KIAA0052; FSAP118; SKIV2L2; Mtr4; Dob1; Functional Spliceosome-Associated Protein 118; Superkiller Viralicidic Activity 2-Like 2; ATP-Dependent RNA Helicase SKIV2L2; ATP-Dependent RNA Helicase DOB1; TRAMP-Like complex Helicase; Exosome RNA Helicase MTR4; Ski2 Like RNA Helicase 2; Superkiller Viralicidic Activity 2-Like 2 (S. Cerevisiae); ATP-Dependent Helicase SKIV2L2; EC 3.6.4.13; EC 3.6.1; DOB1; MTR4
Cat. No.: HY-P812022A
Synonyms: MTREX; Mtr4 Exosome RNA Helicase; KIAA0052; FSAP118; SKIV2L2; Mtr4; Dob1; Functional Spliceosome-Associated Protein 118; Superkiller Viralicidic Activity 2-Like 2; ATP-Dependent RNA Helicase SKIV2L2; ATP-Dependent RNA Helicase DOB1; TRAMP-Like complex Helicase; Exosome RNA Helicase MTR4; Ski2 Like RNA Helicase 2; Superkiller Viralicidic Activity 2-Like 2 (S. Cerevisiae); ATP-Dependent Helicase SKIV2L2; EC 3.6.4.13; EC 3.6.1; DOB1; MTR4
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
