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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
69 Results for "
ALK4
" in MedChemExpress (MCE) Product Catalog:
Products (69)
69 Results for "ALK4" in MCE Product Catalog:
Cat. No.: HY-135509
CAS No.: 1924207-18-0
Synonyms: PF-06463922 acetate
Research Areas:
Lorlatinib (PF-06463922) acetate is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor with anticancer activity. Lorlatinib acetate has Kis of <0.025 nM, <0.07 nM, and 0.7 nM for ROS1, wild type ALK, and ALK L1196M, respectively. Lorlatinib acetate targets to EML4-ALK, and inhibits ALK phosphorylation with IC50s of 15-43 nM (ALK L1196), 14-80 nM (ALK G1269A), 38-50 nM (ALK 1151Tins), 77-113 nM (ALK G1202R), respectively .
Cat. No.: HY-169481
CAS No.: 3027918-96-0
Research Areas:
AP-1 is a targeted ALK PROTAC degrader. AP-1 effectively degrades various ALK fusion/mutation forms, including degradation of NPM-ALK (DC50 = 4.6 nM) and EML4-ALK (DC50 = 357.6 nM), and exhibits a typical hook effect at high concentrations. AP-1 inhibits phosphorylation of downstream STAT3, downregulates gene expression in the JAK-STAT pathway, and kills ALK-positive tumor cells via activating the caspase-3-dependent apoptosis pathway. AP-1 shows cytotoxicity against a variety of cancer cells and possesses anti-tumor activity. AP-1 can be used in research related to non-small cell lung cancer, neuroblastoma, and anaplastic large cell lymphoma .
Cat. No.: HY-13521AR
CAS No.: 356559-13-2
Target:
Research Areas:
SB-505124 (hydrochloride) (Standard) is the analytical standard of SB-505124 (hydrochloride). This product is intended for research and analytical applications. SB-505124 hydrochloride is a selective inhibitor of TGF-β Receptor type I receptor (ALK4, ALK5, ALK7), with IC50s of 129 nM and 47 nM for ALK4, ALK5, respectively, but it does not inhibit ALK1, 2, 3, or 6.
Cat. No.: HY-13521R
CAS No.: 694433-59-5
Target:
Research Areas:
SB-505124 (Standard) is the analytical standard of SB-505124. This product is intended for research and analytical applications. SB-505124 is a selective inhibitor of TGF-β Receptor type I receptors (ALK4, ALK5, ALK7), with IC50s of 129 nM and 47 nM for ALK4, ALK5, respectively, but it does not inhibit ALK1, 2, 3, or 6.
Target:
Research Areas:
EML4-ALK kinase inhibitor 1 is a potent orally active inhibitor of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), with an IC50 of 1 nM .
Cat. No.: HY-E70714
Target:
Research Areas:
EML4-ALK is a fusion-type protein tyrosine kinase produced through gene rearrangement. EML4-ALK can be used for the study of non-small cell lung carcinoma (NSCLC) and neuroblastoma (NB). EML4-ALK has multiple mutants. EML4 ALK F1174L Recombinant Human Active Protein Kinase is a recombinant EML4 ALK F1174L protein that can be used to study EML4 ALK F1174L-related functions .
Cat. No.: HY-161749
CAS No.: 3049802-45-8
Research Areas:
PROTAC ALK degrader-1 (compound B1) is an ALK degrader based on PROTACs, with the DC50 of 26 nM in H3122 EML4-ALK. PROTAC ALK degrader-1 can be used to synthesis PROTAC ALK degrader-2 (HY-161750) with superior bioavailability .
Cat. No.: HY-175849
Research Areas:
ALK degrader 1 is a potent, hydrophobic tag (HyT)-based degrader that induces ubiquitin-proteasome system (UPS)-dependent EML4-ALK degradation (DC50 = 0.13 μM). ALK degrader 1 demonstrates potent ALK degradation and antiproliferative effects in ALK-dependent cell lines, while showing minimal cytotoxicity in ALK fusion-negative cells. ALK degrader 1 triggers cell cycle arrest at the G0/G1 phase and stimulates apoptosis. ALK degrader 1 not only facilitates efficient degradation of the ALK protein but also disrupts key downstream effectors, including the STAT3 signaling axis. ALK degrader 1 mediates robust EML4-ALK degradation in vivo. ALK degrader 1 can be used for ALK-related diseases research .
Cat. No.: HY-174315
Research Areas:
WZH-17-002 is a CRBN‑recruiting ALK PROTAC degrader. WZH‑17‑002 degrades ALK proteins, including EML4‑ALK and the compound mutants. WZH‑17‑002 inhibits the development of drug resistance in ALK‑fusion non‑small‑cell lung cancer. WZH‑17‑002 can be used for research related to non‑small‑cell lung cancer .
Cat. No.: HY-105369
CAS No.: 154015-73-3
Research Areas:
KF-20444 is an orally active ALK inhibitor with blood-brain barrier penetration. KF-20444 exhibits strong inhibitory activity against ALK fusion proteins (EML4-ALK) and ALK resistance mutations (including L1196M, G1202R, and F1174L). KF-20444 effectively suppresses the phosphorylation of ALK in ALK-driven cancer cell lines, thereby inhibiting cancer cell proliferation and inducing apoptosis. KF-20444 demonstrates anti-tumor efficacy in mouse models bearing ALK-positive non-small cell lung cancer (NSCLC) or neuroblastoma. KF-20444 can be used for the study of ALK-driven malignancies .
Cat. No.: HY-175527
Research Areas:
ALK degrader 2 is an orally active ALK HyT degrader that degrades EML4-ALK levels (DC50 = 8 nM) and nucleophosmin (NPM)-ALK protein levels (DC50 = 102 nM). ALK degrader 2 mediates ALK degradation via the Hsp70 chaperone system and ubiquitin-proteasome pathway. ALK degrader 2 induces significant S-phase cell cycle arrest and apoptosis in H3122 cells. ALK degrader 2 shows anti-tumor activity in mice bearing H3122 xenografts. ALK degrader 2 can be used for the study of non-small cell lung cancer (NSCLC). (Pink: ALK ligand (HY-W754809), Blue: Hyt (HY-W013021), Black: Linker (HY-Y1760), ALK ligand-linker conjugate (HY-175528)) .
Cat. No.: HY-P76718
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ACVR1B; Activin Receptor-Like Kinase 4; Prev. ACVRLK4; Activin Receptor Type-1B; ALK4; Activin A Receptor, Type II-Like Kinase 4; SKR2; Activin Receptor Type IB; ActRIB; ACTR-IB; Serine/Threonine-Protein Kinase Receptor R2; ALK-4; Activin A Receptor Type
Species:
Rat
Source:
HEK293
Cat. No.: HY-P77294
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ACVR1B; Activin Receptor-Like Kinase 4; Prev. ACVRLK4; Activin Receptor Type-1B; ALK4; Activin A Receptor, Type II-Like Kinase 4; SKR2; Activin Receptor Type IB; ActRIB; ACTR-IB; Serine/Threonine-Protein Kinase Receptor R2; ALK-4; Activin A Receptor Type
Species:
Rhesus Macaque
Source:
HEK293
Cat. No.: HY-P7486
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: ACVR1B; Activin Receptor-Like Kinase 4; Prev. ACVRLK4; Activin Receptor Type-1B; ALK4; Activin A Receptor, Type II-Like Kinase 4; SKR2; Activin Receptor Type IB; ActRIB; ACTR-IB; Serine/Threonine-Protein Kinase Receptor R2; ALK-4; Activin A Receptor Type
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P705994
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ACVR1B; Activin Receptor-Like Kinase 4; Prev. ACVRLK4; Activin Receptor Type-1B; ALK4; Activin A Receptor, Type II-Like Kinase 4; SKR2; Activin Receptor Type IB; ActRIB; ACTR-IB; Serine/Threonine-Protein Kinase Receptor R2; ALK-4; Activin A Receptor Type
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-111482R
CAS No.: 614749-78-9
Target:
Research Areas:
SM 16 (Standard) is the analytical standard of SM 16 (HY-111482). This product is intended for research and analytical applications. SM 16 is a ALK5/ALK4 Kinase inhibitor with Kis of 10 and 1.5 nM, respectively.
Cat. No.: HY-P75571
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ACVR1B; Activin Receptor-Like Kinase 4; Prev. ACVRLK4; Activin Receptor Type-1B; ALK4; Activin A Receptor, Type II-Like Kinase 4; SKR2; Activin Receptor Type IB; ActRIB; ACTR-IB; Serine/Threonine-Protein Kinase Receptor R2; ALK-4; Activin A Receptor Type 1B; Activin A Receptor, Type IB
Species:
Human
Source:
HEK293
Cat. No.: HY-P75572
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: ACVR1B; Activin Receptor-Like Kinase 4; Prev. ACVRLK4; Activin Receptor Type-1B; ALK4; Activin A Receptor, Type II-Like Kinase 4; SKR2; Activin Receptor Type IB; ActRIB; ACTR-IB; Serine/Threonine-Protein Kinase Receptor R2; ALK-4; Activin A Receptor Type 1B; Activin A Receptor, Type IB
Species:
Human
Source:
HEK293
Cat. No.: HY-P7485
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ACVR1B; Activin Receptor-Like Kinase 4; Prev. ACVRLK4; Activin Receptor Type-1B; ALK4; Activin A Receptor, Type II-Like Kinase 4; SKR2; Activin Receptor Type IB; ActRIB; ACTR-IB; Serine/Threonine-Protein Kinase Receptor R2; ALK-4; Activin A Receptor Type 1B; Activin A Receptor, Type IB
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
