3049802-45-8
3049802-45-8
Chemical Structure
PROTAC ALK degrader-1
- CAS No.: 3049802-45-8
- Formula:C47H55ClN10O9S
- Molecular Weight:971.52
InChIKey: AQSXITZTNPSWAK-UHFFFAOYSA-N
SMILES: CC(C)S(C1=C(NC2=C(Cl)C=NC(NC3=C(OC(C)C)C=C(C4CCN(CC(NCC(NCCNC5=CC=CC(C(N6C7CCC(NC7=O)=O)=O)=C5C6=O)=O)=O)CC4)C(C)=C3)=N2)C=CC=C1)(=O)=O
Biological Activity: PROTAC ALK degrader-1 (compound B1) is an ALK degrader based on PROTACs, with the DC50 of 26 nM in H3122 EML4-ALK. PROTAC ALK degrader-1 can be used to synthesis PROTAC ALK degrader-2 (HY-161750) with superior bioavailability[1].
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PROTAC ALK degrader-1 | PROTAC ALK degrader-1 (compound B1) is an ALK degrader based on PROTACs, with the DC50 of 26 nM in H3122 EML4-ALK. PROTAC ALK degrader-1 can be used to synthesis PROTAC ALK degrader-2 (HY-161750) with superior bioavailability. | |||||||||||||||||||||
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