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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
40 Results for "
Arg1
" in MedChemExpress (MCE) Product Catalog:
Products (40)
40 Results for "Arg1" in MCE Product Catalog:
Cat. No.: HY-P991870
Cat. No.: HY-RS14543
Target:
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TINAGL1 Human Pre-designed siRNA Set A contains three designed siRNAs for TINAGL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-163426S
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Cat. No.: HY-P6423S
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Cat. No.: HY-100742AR
CAS No.: 2003234-63-5
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(R)-GNE-140 (Standard) is the analytical standard of (R)-GNE-140 (HY-100742A). This product is intended for research and analytical applications. (R)-GNE-140 is a potent inhibitor of lactate dehydrogenase (LDH) A, B and C, with IC50 values of 3, 5 and 5 nM against LDHA, LDHB, LDHC, respectively. (R)-GNE-140 blocks the conversion of pyruvate to lactate, reduces lactate production and histone lysine lactylation, and inhibits glycolysis. (R)-GNE-140 attenuates cardiac hypertrophy, alleviates PM2.5-induced pulmonary inflammation and fibrosis, blocks MRSA-induced Arg1 expression. (R)-GNE-140 is applicable to research related to pathological cardiac hypertrophy, pulmonary fibrosis, MRSA infection and pancreatic cancer [1] .
Cat. No.: HY-N20682
CAS No.: 2866266-56-8
Target:
Cat. No.: HY-P71369
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TINAGL1; Lipocalin 7; Prev. LCN7; OLRG-2; TINAGRP; Tubulointerstitial Nephritis Antigen-Like 1, Isoform CRA_a; P3ECSL; Oxidized LDL-Responsive Gene 2 Protein; LIECG3; Oxidized-LDL Responsive Gene 2; Arg1; Androgen Regulated Gene 1; Tubulointerstitial Neph
Species:
Human
Source:
HEK293
Cat. No.: HY-P11882
CAS No.: 947545-69-9
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Cat. No.: HY-187035
CAS No.: 868066-26-6
SNX631 is an orally active and selective CDK8/CDK19 inhibitor. SNX631 reduces the phosphorylation of STAT1/STAT3 S727, and upregulates miR-21-5p, miR-21-3p and miR-221 in cancer cells. SNX631 transcription-independently inhibits meiotic resumption in mouse oocytes, blocks nuclear envelope breakdown, first polar body extrusion and mitochondrial expansion and aggregation, with no cytotoxicity. SNX631, in combination with Lapatinib (HY-50898) or Trastuzumab (HY-P9907), synergistically inhibits cancer cell growth, upregulates the tumor suppressor BTG2, prevents Lapatinib-induced upregulation of oncogenic miRNAs, overcomes drug resistance, reduces the infiltration of αSMA+ stromal fibroblasts and ARG1+ M2 macrophages, and exhibits favorable biosafety. SNX631 can be used in studies related to HER2-positive breast cancer and cancer [1] .
Cat. No.: HY-RS18727
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Research Areas:
Tinagl1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tinagl1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P6421S
Target:
Cat. No.: HY-P6422S
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Cat. No.: HY-P6424S
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Cat. No.: HY-P6425S
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Cat. No.: HY-182719
CAS No.: 2374807-41-5
AZD0011, a prodrug of AZD0011-PL (HY-182718), is an orally active arginase 1 inhibitor with an IC50 of 328 nM. AZD0011 undergoes in vivo hydrolysis to release an arginase inhibitor payload, inhibiting arginine hydrolysis, increases arginine levels in plasma and the tumor microenvironment. AZD0011 restores innate immune function and inhibits tumor growth. AZD0011 can be used for the research of cancer, such as fibrosarcoma [1].
Cat. No.: HY-184203
SM-06-09 is a potent, highly selective, orally active tetrazolone-based HDAC6 inhibitor with an IC50 value of 0.49 nM. SM-06-09 promotes tumor-associated macrophage (TAM) polarization toward an antitumor M1-like phenotype and enhances macrophage phagocytosis, antigen presentation, and T-cell activation. SM-06-09 remodels the tumor immune microenvironment, exhibits antitumor activity in melanoma models, and enhances the efficacy of anti-PD-1 immune checkpoint blockade [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
