![Pyrrolo[2,1-f][1,2,4]triazin-4-amine](https://file.medchemexpress.com/product_pic/hy-w003471.gif "Click to View Pyrrolo[2,1-f][1,2,4]triazin-4-amine Product Detail")
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
29 Results for "
Map4k4
" in MedChemExpress (MCE) Product Catalog:
Products (29)
29 Results for "Map4k4" in MCE Product Catalog:
Cat. No.: HY-P702743
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: Map4k4; Non-Specific Serine/Threonine Protein Kinase; Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4; Epididymis Secretory Protein Li 31; HGK; Ste20 Group Protein Kinase HGK; NIK; Uncharacterized Protein Map4k4; FLH21957; HPK/GCK-Like Kinase; Hep
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-W003471
CAS No.: 159326-68-8
Pyrrolo[2,1-f][1,2,4]triazin-4-amine is a MAP4K4 inhibitor with a surface plasmon resonance (SPR) Kd of 88 μM and a ligand efficiency of 0.56 .
Cat. No.: HY-100343R
CAS No.: 1449277-10-4
Target:
Research Areas:
GNE-495 (Standard) is the analytical standard of GNE-495 (HY-100343). This product is intended for research and analytical applications. GNE-495 is a potent and selective MAP4K4 inhibitor with an IC50 of 3.7 nM.
Cat. No.: HY-111754R
CAS No.: 2306178-56-1
Target:
Research Areas:
DMX-5804 (Standard) is the analytical standard of DMX-5804 (HY-111754). This product is intended for research and analytical applications. DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice .
Cat. No.: HY-P81378A
Synonyms: Map4k4; HGK, KIAA0687, NIK; Mitogen-activated protein kinase kinase kinase kinase 4; HPK/GCK-like kinase HGK; MapK/ERK kinase kinase kinase 4 (MEK kinase kinase 4; MEKKK 4); Nck-interacting kinase
Cat. No.: HY-W207224
CAS No.: 287177-12-2
Target:
Research Areas:
F1386-0303 is a highly selective MAP4K4 inhibitor with an IC50 of 34 nM against human targets. F1386-0303 exerts cardiomyocyte protective and function-preserving effects through mechanisms such as alleviating oxidative stress, inhibiting caspases, and maintaining mitochondrial membrane potential, while it does not interfere with the activity of Doxorubicin (HY-15142A) in cancer cells. F1386-0303 is rapidly cleared and has no bioavailability in mice, but it is well-suited as a tool compound for target validation. F1386-0303 can be applied to studies related to cardiac ischemia-reperfusion injury, Doxorubicin-induced cardiotoxicity, myocardial infarction and other related conditions .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
