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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
42 Results for "
PDC
" in MedChemExpress (MCE) Product Catalog:
Products (42)
42 Results for "PDC" in MCE Product Catalog:
Cat. No.: HY-179166
Target:
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PROTAC sEH degrader-4 is a highly efficient PROTAC degrader that targets soluble epoxide hydrolase (sEH) (pDC50 = 10.3). PROTAC sEH degrader-4 can be used for research on inflammation-related diseases .
Cat. No.: HY-P990276
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Cat. No.: HY-170838
PDHK1-IN-1 (compound 17) is a selective inhibitor of PDHK1 (IC50=1.5 μM) with anticancer activity. PDHK1 negatively regulates the pyruvate dehydrogenase complex (PDC), limiting the tricarboxylic acid (TCA) cycle and oxidative phosphorylation. Overexpression of PDHK1 can shift the metabolism towards an increased glycolysis dependence (Warburg effect). PDHK1-IN-1 can inhibit the phosphorylation of the PDC E1α Ser232 recognition site of PDHK1 and the phosphorylation of Ser293 .
Cat. No.: HY-P11018
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Cat. No.: HY-RS10184
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PDC Human Pre-designed siRNA Set A contains three designed siRNAs for PDC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23854
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Pdc Rat Pre-designed siRNA Set A contains three designed siRNAs for Pdc gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS10777
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PNKD Human Pre-designed siRNA Set A contains three designed siRNAs for PNKD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P1094
CAS No.: 331645-84-2
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AZ-10417808 is a selective caspase-3 inhibitor. AZ-10417808 blocks apoptosis signaling pathway by inhibiting caspase-3 activity. AZ-10417808 can be used to study the effect of nicotine on plasmacytoid dendritic cell migration .
Cat. No.: HY-106195
CAS No.: 207395-85-5
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L 377202 is a peptide-drug conjugate (PDC). L 377202 consists of Doxorubicin (HY-15142A) and a prostate-specific antigen (PSA)-hydrolyzable peptide. L 377202 demonstrates strong inhibitory effects on PSA-secreting prostate cancer cells. L 377202 is promising for research of prostate cancer .
Cat. No.: HY-182173
CAS No.: 193631-87-7
pdC-CE phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
Cat. No.: HY-RS17399
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Pdc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pdc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-188016
CAS No.: 3086791-83-2
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MC-GGFG-TriPtolide is a peptide-drug conjugate (PDC) composed of a cell-penetrating peptide (MC), a cathepsin-cleavable GGFG peptide linker, and the payload drug Triptolide (HY-32735), and it is used for targeted intracellular delivery .
Cat. No.: HY-138794B
CAS No.: 2417089-75-7
Synonyms: (R)-XL177A
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XL177B is an inactive (R) enantiomer of XL177A (HY-138794). XL177B has no effect on CD86 or HLA-DR expression on pDCs. XL177B serves as a negative control. XL177B can be used in the research of multiple myeloma .
Cat. No.: HY-W800833
CAS No.: 55946-27-5
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Benzyl N-[2-(prop-2-enamido)ethyl]carbamate is a short aliphatic linker featuring a Cbz-protected amine and an acrylamide. Acrylamide is a Michael acceptor which is a good Michael acceptor which can be used in thiol-based bioconjugation or polymerization. Meanwhile, the Cbz protecting group can be removed using Pd-C hydrogenation to reveal a free amine that can participate in a wide variety of reactions such as couplings or reductive amination.
Cat. No.: HY-183718
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M4K3250 is a selective ALK2 PROTAC degrader with a pDC50 of 7.9. M4K3250 induces the formation of a ternary complex between ALK2 and the E3 ubiquitin ligase CRBN, thereby causing ALK2 degradation and inhibiting ALK2 activity. M4K3250 exhibits cytotoxicity in glioblastoma cells. M4K3250 can be used in studies related to glioblastoma .
Cat. No.: HY-183717
Research Areas:
M4K3233 is a selective ALK2 PROTAC degrader with a pDC50 of 7.3 and a pIC50 of 6.6. M4K3233 recruits CRBN to form a ternary complex with ALK2, mediating ALK2 degradation via the proteasomal and lysosomal pathways. M4K3233 induces moderate downregulation of RIPK2 and significant downregulation of SIK3 in mammalian cells. M4K3233 is applicable to research related to glioblastoma .
Cat. No.: HY-P75286
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: DLAT; E2 Component Of Pyruvate Dehydrogenase Complex; Prev. DLTA; M2 Antigen Complex 70 KDa Subunit; PDC-E2; PDCE2; Dihydrolipoyllysine-Residue Acetyltransferase Component Of Pyruvate Dehydrogenase Complex, Mitochondrial; PBC; Dihydrolipoamide Acetyltrans
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P80292
Synonyms: DLTA, DLAT, 70 kDa mitochondrial autoantigen of primary biliary cirrhosis, Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, M2 antigen complex 70 kDa subunit, Pyruvate dehydrogenase complex component E2, PBC, PDC-E2, PDCE2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
