PROTAC sEH-degrader-4
PROTAC sEH-degrader-4 is a highly efficient PROTAC degrader that targets soluble epoxide hydrolase (sEH) (pDC50 = 10.3). PROTAC sEH-degrader-4 can be used for research on inflammation-related diseases.
(Pink: sEH ligand (HY-179169); Blue: Cereblon ligand (HY-179168); Black: linker).
For research use only. We do not sell to patients.
- Formula: C45H49F3N10O8
- Molecular Weight:914.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
PROTAC sEH-degrader-4 (Compound P4) (300 nM, 18 h) exhibits extreme degradation activity, with a pDC50 of 10.3 after 18 hours of incubation and a maximum degradation efficiency (Dmax = 96 %) in HeLa cells stably overexpressing the sEH-HiBiT fusion protein (HeLasEH-HiBiT). Significant degradation is also observed after a shorter incubation period of 6 hours[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 914.93
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Formula C45H49F3N10O8
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SMILES
O=C(NCCCC1=CN(CCN2CCN(C3=CC4=C(C(N(C(CC5)C(NC5=O)=O)C4=O)=O)C=C3)CC2)N=N1)C6=CC=C(O[C@H]7CC[C@H](NC(NC8=CC=C(OC(F)(F)F)C=C8)=O)CC7)C=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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