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Cat. No.: HY-179166

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PROTAC sEH degrader-4

PROTAC sEH degrader-4 is a highly efficient PROTAC degrader that targets soluble epoxide hydrolase (sEH) (pDC₅₀ = 10.3). PROTAC sEH degrader-4 can be used for research on inflammation-related diseases.
(Pink: ligand (HY-179169); Blue: Cereblon ligand (HY-179168); Black: linker).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₄₅H₄₉F₃N₁₀O₈
Masse moléculaire:914.93

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

PROTAC sEH degrader-4 Chemical Structure

Stock

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Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

PROTAC sEH degrader-4 is a highly efficient PROTAC degrader that targets soluble epoxide hydrolase (sEH) (pDC₅₀ = 10.3). PROTAC sEH degrader-4 can be used for research on inflammation-related diseases^[1]. (Pink: ligand (HY-179169); Blue: Cereblon ligand (HY-179168); Black: linker).

Voir tous les produits spécifiques à Isoform PROTACs :

In Vitro

PROTAC sEH degrader-4 (Compound P4) (300 nM, 18 h) exhibits extreme degradation activity, with a pDC₅₀ of 10.3 after 18 hours of incubation and a maximum degradation efficiency (D_max = 96 %) in HeLa cells stably overexpressing the sEH-HiBiT fusion protein (HeLasEH-HiBiT). Significant degradation is also observed after a shorter incubation period of 6 hours^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Inflammation-related Diseases

Chemical Information

Masse moléculaire 914.93
Formule C₄₅H₄₉F₃N₁₀O₈
SMILES

O=C(NCCCC1=CN(CCN2CCN(C3=CC4=C(C(N(C(CC5)C(NC5=O)=O)C4=O)=O)C=C3)CC2)N=N1)C6=CC=C(O[C@H]7CC[C@H](NC(NC8=CC=C(OC(F)(F)F)C=C8)=O)CC7)C=C6
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Schönfeld J, et al. Click chemistry enables rapid development of potent sEH PROTACs using a direct-to-biology approach. Chem Commun (Camb). 2025 Nov 13;61(92):18108-18111. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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