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Cat. No.: HY-179168

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Thalidomide-C4-N2-C2-N3

Thalidomide-C4-N2-C2-N3 is an E3 ligase ligand. Thalidomide-C4-N2-C2-N3 can bind to a target protein ligand with a linker to form a PROTAC molecule, PROTAC sEH-degrader-4 (HY-179166).

For research use only. We do not sell to patients.

CAS No.: 2825005-43-2
Formula: C₁₉H₂₁N₇O₄
Molecular Weight:411.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Thalidomide-C4-N2-C2-N3 Chemical Structure

CAS No.: 2825005-43-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Thalidomide-C4-N2-C2-N3 is an E3 ligase ligand. Thalidomide-C4-N2-C2-N3 can bind to a target protein ligand with a linker to form a PROTAC molecule, PROTAC sEH-degrader-4 (HY-179166)^[1].

IC₅₀ & Target^[1]

Cereblon

All Ligands for E3 Ligase Isoforms :

In Vitro

PROTAC sEH-degrader-4 contain two different ligands connected by a linker; one is an E3 ligase ligand (Thalidomide-C4-N2-C2-N3) (Compound N17) (HY-179168) and the other is for Ligands of sEH target protein (sEH-H ligand 2) (Compound A3) (HY-178826). PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2825005-43-2
Molecular Weight 411.41
Formula C₁₉H₂₁N₇O₄
SMILES

O=C(C1=C2C=CC(N3CCN(CCN=[N+]=[N-])CC3)=C1)N(C(CC4)C(NC4=O)=O)C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Schönfeld J, et al. Click chemistry enables rapid development of potent sEH PROTACs using a direct-to-biology approach. Chem Commun (Camb). 2025 Nov 13;61(92):18108-18111. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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