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Cat. No.: HY-179168

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Thalidomide-C4-N2-C2-N3

Thalidomide-C4-N2-C2-N3 is an E3 ligase ligand. Thalidomide-C4-N2-C2-N3 can bind to a target protein ligand with a linker to form a PROTAC molecule, PROTAC sEH-degrader-4 (HY-179166).

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CAS No.: 2825005-43-2
Formule: C₁₉H₂₁N₇O₄
Masse moléculaire:411.41

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Thalidomide-C4-N2-C2-N3 Chemical Structure

CAS No.: 2825005-43-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Thalidomide-C4-N2-C2-N3 is an E3 ligase ligand. Thalidomide-C4-N2-C2-N3 can bind to a target protein ligand with a linker to form a PROTAC molecule, PROTAC sEH-degrader-4 (HY-179166)^[1].

IC₅₀ & Target

^[1]

Cereblon

Voir tous les produits spécifiques à Isoform Ligands for E3 Ligase :

In Vitro

PROTAC sEH-degrader-4 contain two different ligands connected by a linker; one is an E3 ligase ligand (Thalidomide-C4-N2-C2-N3) (Compound N17) (HY-179168) and the other is for Ligands of sEH target protein (sEH-H ligand 2) (Compound A3) (HY-178826). PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2825005-43-2
Masse moléculaire 411.41
Formule C₁₉H₂₁N₇O₄
SMILES

O=C(C1=C2C=CC(N3CCN(CCN=[N+]=[N-])CC3)=C1)N(C(CC4)C(NC4=O)=O)C2=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Schönfeld J, et al. Click chemistry enables rapid development of potent sEH PROTACs using a direct-to-biology approach. Chem Commun (Camb). 2025 Nov 13;61(92):18108-18111. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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