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![(2'R,7R,8R,10S,13S,14S)-Methyl 10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,10,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate (Standard)](https://file.medchemexpress.com/product_pic/hy-w105644r.gif "Click to View (2'R,7R,8R,10S,13S,14S)-Methyl 10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,10,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate (Standard) Product Detail")
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
46 Results for "
Spiro
" in MedChemExpress (MCE) Product Catalog:
Products (46)
46 Results for "Spiro" in MCE Product Catalog:
Cat. No.: HY-W057101
CAS No.: 170508-14-2
Target:
Research Areas:
Methyl 6-{[(tert-butoxy)carbonyl]amino}spiro[3.3]heptane-2-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.
Cat. No.: HY-159487
Research Areas:
(2S,4R)-4-Hydroxy-1-((S)-2-(6-(4-methoxyphenyl)spiro[3.3]heptane-2-carboxamido)-3,3-dimethylbutanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide is an E3 ligase ligand-linker conjugate.
Cat. No.: HY-N1262
CAS No.: 1312716-25-8
Synonyms: Scutehenanine B
Category:
Target:
Cat. No.: HY-159539
CAS No.: 2226571-47-5
Target:
Research Areas:
PROTAC SMARCA2 degrader-6-Linker is a PROTAC linker.
Cat. No.: HY-N3534
CAS No.: 64052-90-0
Synonyms: CannabiSpirol
Target:
Cat. No.: HY-119697
CAS No.: 182926-45-0
Synonyms: (+)-Setosusin
Target:
Cat. No.: HY-N11663
CAS No.: 1403505-97-4
Target:
Cat. No.: HY-45169R
CAS No.: 127452-30-6
Target:
Ethyl 2-(6-(acetamidomethyl)-5-oxo-2,3-dihydro-5H-spiro[indolizine-1,2'-[1,3]dioxolan]-7-yl)butanoate (Standard) is the analytical standard of Ethyl 2-(6-(acetamidomethyl)-5-oxo-2,3-dihydro-5H-spiro[indolizine-1,2'-[1,3]dioxolan]-7-yl)butanoate. This product is intended for research and analytical applications.
Cat. No.: HY-172588
Target:
Research Areas:
GABAA receptor modulator-7 (compound 1m), a spiro-Barbiturate, is a GABAA receptor modulator. GABAA receptor modulator-7 reverses the action of anesthetics without affecting GABA-induced desensitization and can be used for study of antiepileptics and anxiolytics .
Cat. No.: HY-135208
CAS No.: 916048-02-7
Target:
Research Areas:
tert-Butyl 2-(5-chloro-2,2'-dioxospiro[indole-3,3'-pyrrolidine]-1-yl)acetate is an intermediate used in the synthesis of potent DP2 receptor antagonists based on a novel spiro-indolinone compound .
Target:
Research Areas:
Menin-MLL inhibitor 19, a potent exo-aza spiro inhibitor of menin-mll interaction, example A17, extracted from patent WO2019120209A1. Menin-MLL inhibitor 19 can be used for the reseaech of various diseases, such as cancer, myelodysplastic syndrome (MDS) and diabetes .
Cat. No.: HY-170490
Target:
Research Areas:
TTQ-SA is a near-infrared (NIR) spiro-AIEgen (aggregation-induced emission luminogen), that converts near-infrared light (NIR) into thermal energy, causing thermal damage and death of tumor cells. TTQ-SA exhibits cellular uptake and targeting ability in cancer cell MF-7. TTQ-SA silences the expression of survivin gene with combination of DNAzyme, enhances the sensitivity of tumor cells to photothermal therapy .
Cat. No.: HY-W008378R
CAS No.: 37052-78-1
Research Areas:
5-Methoxy-2-benzimidazolethiol (Standard) is the analytical standard of 5-Methoxy-2-benzimidazolethiol (HY-W008378). This product is intended for research and analytical applications. 5-Methoxy-2-benzimidazolethiol is a benzimidazole derivative. 5-Methoxy-2-benzimidazolethiol can serve as a ligand for transition metal complexes .
Cat. No.: HY-W008378S
CAS No.: 1219804-80-4
Research Areas:
5-Methoxy-2-benzimidazolethiol-d3 is the deuterated-labeled 5-Methoxy-2-benzimidazolethiol (HY-W008378). 5-Methoxy-2-benzimidazolethiol is a benzimidazole derivative. 5-Methoxy-2-benzimidazolethiol can serve as a ligand for transition metal complexes .
Cat. No.: HY-W699846
CAS No.: 922730-86-7
Research Areas:
5-(Methoxy-d3)-1H-benzo[d]imidazole-2-thiol is the deuterated-labeled 5-Methoxy-2-benzimidazolethiol (HY-W008378). 5-Methoxy-2-benzimidazolethiol is a benzimidazole derivative. 5-Methoxy-2-benzimidazolethiol can serve as a ligand for transition metal complexes .
Cat. No.: HY-160969
CAS No.: 1642147-15-6
Research Areas:
Spiro-duocarmycin is a DNA minor groove N3-adenine alkylating agent. Spiro-duocarmycin exerts cytotoxic effects via DNA alkylation. Spiro-duocarmycin is the active spirocyclized form of seco-DUBA, which is incorporated as an inactive prodrug into the linker-drug construct of antibody-drug conjugates (ADCs). DUBA serves as an ADC payload that can be conjugated with monoclonal antibodies to synthesize antibody-drug conjugates (ADCs) .
Target:
Research Areas:
closed-HMRG is an HMRG (HY-D2379) with a closed spiro-ring structure. HMRG is a fluorescent dye, which serves as the fluorescent active product generated by enzyme-activated fluorescent probes targeting proteases and glycosidases. Its detection mechanism relies on the intramolecular spirocyclization equilibrium: HMRG itself exists in an open non-spirocyclic structure under physiological pH, which maintains a conjugated π system and produces strong fluorescence; whereas its probe precursors (such as Leu-HMRG, Ac-GlyPro-HMRG and βGal-HMRG) exist in a closed spirocyclic form and show no fluorescence due to the disruption of the π-conjugated system; when the target enzyme cleaves the substrate fragment linked to the probe precursor, the closed spirocyclic structure converts to the open structure of HMRG, restoring the conjugated system and generating a strong fluorescent signal. Its detection wavelength is Ex/Em = 501/524 nm .
Cat. No.: HY-W105644R
CAS No.: 95716-70-4
Synonyms: Δ9,11-Eplerenone (Standard)
Target:
(2'R,7R,8R,10S,13S,14S)-Methyl 10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,10,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate (Standard) is the analytical standard of (2'R,7R,8R,10S,13S,14S)-Methyl 10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,10,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate. This product is intended for research and analytical applications.
Cat. No.: HY-N7292A
CAS No.: 21807-96-5
Target:
Cat. No.: HY-L943
37030 compounds
MCE-18 stands for Medicinal Chemistry Evolution 2018, which was first published in Journal of Medicinal Chemistry in 2019 for assessing molecular novelty and three-dimensional complexity. Developed based on Clarivate global pharmaceutical patent database, this descriptor was constructed via big-data analysis covering 28,161 patented lead compounds, 1,370 approved drugs and nearly 30,000 preclinical-to-phase III drug candidates from 23 top pharmaceutical companies worldwide between 1950 and 2018, followed by structural clustering and removal of redundant outdated scaffolds for data denoising. Its scoring system integrates five core structural features including aromatic ring (AR), aliphatic heterocycle (NAR), chiral center (CHIRAL), spiro atom (SPIRO), cyclic and acyclic sp³ carbon ratio together with a quadratic topological correction factor. Breaking the limitations of the single Fsp³ parameter, MCE-18 effectively distinguishes conventional flat aromatic scaffolds from modern 3D-enriched novel chemotypes, overcoming typical drawbacks of traditional compound libraries such as scaffold redundancy, low screening hit rates and poor compatibility with allosteric and PPI-related difficult targets.
This library contains over 37,000 structurally diverse compounds with favorable overall drug-likeness, suitable for high-throughput screening against canonical targets including kinases, GPCRs and proteases as well as challenging allosteric and PPI targets. Compounds comply with the developmental trend of modern novel drug discovery, supporting routine primary screening as well as early hit identification of allosteric modulators and PPI inhibitors, serving as an efficient screening resource for early-stage innovative drug discovery.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
