Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
brain catecholamine
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "brain catecholamine" in MCE Product Catalog:
Synonyms: DHEA sulfate sodium (Standard); Prasterone sulfate sodium (Standard)
Category:
Cat. No.: HY-106470
CAS No.: 20170-20-1
Synonyms: Pasalin
Target:
Research Areas:
Difenamizole (Pasalin) is an orally active pyrazole non-steroidal anti-inflammatory agent and pain inhibitor, which capable of crossing the blood-brain barrier. Difenamizole inhibits the release of catecholamines by monoaminergic neurons, reduces the concentrations of dopamine metabolites and normetanephrine (NE) in the striatum, and thereby regulates the levels of dopamine and norepinephrine in the brain. Difenamizole is not only antagonized by dopamine in the brain, but also exerts synergistic effects with Oxidopamine (6-OHDA) (HY-B1081/A), Phenoxybenzamine (HY-B0431), Reserpine (HY-N0480), and other agents. Difenamizole inhibits conditioned, emotional and aggressive behaviors in rodents, and can be used in studies of pain and related neurobehaviors .
Cat. No.: HY-N2332
CAS No.: 21019-30-7
Synonyms: MLA
Cat. No.: HY-N2332AR
CAS No.: 351344-10-0
Synonyms: MLA citrate (Standard)
Research Areas:
Methyllycaconitine citrate (Standard) is the analytical standard of Methyllycaconitine citrate (HY-N2332A). This product is intended for research and analytical applications. Methyllycaconitine (MLA) citrate is a blood-brain barrier-permeable antagonist of α7 nicotinic acetylcholine receptor (α7nAChR) with an IC50 of 2 nM. Methyllycaconitine citrate inhibits Aβ25-35-induced autophagy by restoring the mTOR pathway, and prevents reactive oxygen species (ROS) production, microglial activation, reduced dopamine uptake, loss of dopaminergic terminals and catecholamine secretion. Methyllycaconitine citrate induces hippocampal glutamate efflux, enhances long-term potentiation, and improves memory acquisition. Methyllycaconitine citrate can be used in research related to Alzheimer's disease, cerebral palsy, ParKinson's disease and schizophrenia .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
