509 Results for "

CD3+

" in MedChemExpress (MCE) Product Catalog:
Products (509)

509 Results for "CD3+" in MCE Product Catalog:

Noscapine-13C,d3
Noscapine-13C,d3
0 Images
Cat. No.: HY-13716S
CAS No.: 1217680-57-3
Noscapine- 13C,d3 is a 13C- labeled and deuterated labeled Noscapine . Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier [3] .
loading...
    loading...
View All Sizes
Rosuvastatin-13C,d3 sodium
Rosuvastatin-13C,d3 sodium
0 Images
Cat. No.: HY-17504BS2
Synonyms: ZD 4522-13C,d3 sodium; X-Plended-13C,d3 sodium; Crestor-13C,d3 sodium
Rosuvastatin- 13C,d3 sodium is 13C and deuterated labeled Rosuvastatin sodium (HY-17504B). Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM . Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels [3].
loading...
    loading...
View All Sizes
2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine-13C,d3
2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine-13C,d3
0 Images
Cat. No.: HY-33202S
2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine- 13C,d3 is the 13C- and deuterium labeled 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine.
loading...
    loading...
View All Sizes
Nelvutamig
Nelvutamig
0 Images
Cat. No.: HY-P991706
CAS No.: 3029433-56-2

Target:  

Phosphodiesterase (PDE) CD3

Research Areas:  

Cancer

Nelvutamig is a humanized immunoglobulin (H-gamma1_L-kappa)_scFvkh-G1(h-CH2-CH3) antibody targeting ENPP3/CD203c and CD3E. The corresponding isotype control is: Human immunoglobulin (H-gamma1_L-kappa)_scFvkh-G1(h-CH2-CH3) .
loading...
    loading...
View All Sizes
HPN601
HPN601
0 Images
Cat. No.: HY-P992370

Target:  

Transmembrane Glycoprotein Interleukin Related IFNAR

Research Areas:  

Cancer

HPN601 is a monoclonal antibody targeting CD326/EPCAM, as well as a protease-activated EpCAM-targeted T cell engager. HPN601 binds to EPCAM, CD3e and albumin, and induces T cell-mediated tumor cell killing. HPN601 significantly reduces the release levels of IFN-γ, IL-2, IL-6, and IL-10. HPN601 can be used for relevant research on cancers such as breast cancer and gastric cancer .
loading...
    loading...
View All Sizes
Trimegestone-13C,d3
Trimegestone-13C,d3
0 Images
Cat. No.: HY-106827S1
Synonyms: RU 27987-13C,d3
Trimegestone- 13C,d3 is 13C and deuterated labeled Trimegestone (HY-106827). Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC50 value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC50=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes .
loading...
    loading...
View All Sizes
Famotidine-13C,d3
Famotidine-13C,d3
0 Images
Cat. No.: HY-B0377S
CAS No.: 2744683-81-4
Synonyms: MK-208-13C,d3
Famotidine- 13C,d3 (MK-208- 13C,d3) is the deuterated, 13C-labeled Famotidine (HY-B0377). Famotidine (MK-208) is an orally active and highly selective histamine H2 receptor antagonist. It inhibits gastric acid secretion by blocking the Gs signaling pathway, and regulates intracellular cAMP and ERK pathways. Famotidine inhibits TLR3-mediated inflammatory pathways, and reduces the expression of various inflammatory mediators and interferon-related genes. Famotidine scavenges DPPH and nitric oxide free radicals, alleviates oxidative stress damage in gastric tissue, inhibits proMMP-9, improves vascular endothelial permeability, and restores the normal physiological functions of neutrophils and eosinophils. Famotidine crosses intestinal epithelial cells via facilitated diffusion and passive diffusion, blocks paracellular cation transport, and increases intestinal transepithelial electrical resistance. Famotidine reduces serum levels of transaminases and alkaline phosphatase, exerts analgesic effects and gastric protective effects simultaneously. Famotidine can be used in studies related to COVID-19, liver injury and acute gastric ulcer [3] .
loading...
    loading...
View All Sizes
Simeprevir-13C,d3
Simeprevir-13C,d3
0 Images
Cat. No.: HY-10241S
Synonyms: TMC435-13C,d3; TMC435350-13C,d3
Simeprevir- 13C,d3 is the 13C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses .
loading...
    loading...
View All Sizes
Clopidogrel-13C,d3 sulfate
Clopidogrel-13C,d3 sulfate
0 Images
Cat. No.: HY-107867S2
CAS No.: 1246814-55-0
Clopidogrel- 13C,d3 sulfate is the deuterium and 13C-labeled (±)-Clopidogrel (bisulfate) (HY-107867). (±)-Clopidogrel bisulfate is a platelet P2Y12 receptor inhibitor and an adenosine diphosphate (ADP) receptor antagonist. (±)-Clopidogrel bisulfate inhibits the binding of ADP to its receptors on the membranes of platelet cells, and blocks ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (±)-Clopidogrel bisulfate reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. (±)-Clopidogrel bisulfate has anti-inflammatory effects .
loading...
    loading...
View All Sizes
9(R)-HODE
9(R)-HODE
0 Images
Cat. No.: HY-113545
CAS No.: 10075-11-3
Synonyms: 9(R)-Hydroxyoctadecadienoic acid
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease

9(R)-HODE is a monohydroxy fatty acid and metabolite of linoleic acid. It is formed from linoleic acid by COX and lipoxygenase (LO).9(R)-HODE induces chemotaxis, increases the levels of chemokine (C-C motif) receptor 9 (CCR9) and chemokine (C-X-C motif) receptor 4 (CXCR4), and inhibits IL-6 release in primary human monocytes. It inhibits CD3α- and CD28-induced proliferation of isolated human peripheral blood lymphocytes when used at a concentration of 25 μg/mL.
loading...
    loading...
View All Sizes
Ondansetron-13C,d3
Ondansetron-13C,d3
0 Images
Cat. No.: HY-B0002BS2
CAS No.: 2699607-85-5
Synonyms: GR 38032-13C,d3; SN 307-13C,d3
Ondansetron- 13C,d3 is the 13C- and deuterium labeled Ondansetron (HY-B0002B). Ondansetron (GR 38032; SN 307) is a highly selective 5-HT3 receptor antagonist with an IC50 value of 103 pM. Ondansetron exerts its antiemetic effect by antagonizing 5-HT receptors located in localized neurons in the peripheral and central nervous systems. Ondansetron can inhibit nausea and vomiting induced by chemotherapy and radiotherapy [3] .
loading...
    loading...
View All Sizes
Moxonidine-13C,d3 hydrochloride
Moxonidine-13C,d3 hydrochloride
0 Images
Cat. No.: HY-B0374AS
Synonyms: BDF5895-13C,d3 hydrochloride
Moxonidine- 13C,d3 hydrochloride is 13C and deuterated labeled Moxonidine hydrochloride (HY-B0374A). Moxonidine (BDF5895) is an orally active imidazoline type 1 receptor (I1-R) agonist. Moxonidine activates imidazoline I1 receptors and α2 adrenoceptors, affecting oxidized low-density lipoprotein uptake. Moxonidine reduces atherosclerotic lesions and lowers blood pressure. Moxonidine can be used in the study of hypertension, heart failure, and atherosclerosis [3] .
loading...
    loading...
View All Sizes
Azasetron Hydrochloride-13C,d3
Azasetron Hydrochloride-13C,d3
0 Images
Cat. No.: HY-W777959
CAS No.: 1329611-23-5
Azasetron Hydrochloride- 13C,d3 is the deuterium and 13C-labeled Azasetron (HY-B0019). Azasetron ((Rac)-SENS-401 free base) is an antiemetic drug with 5-HT3 receptor antagonist activity. Azasetron is often used as a preventive measure for postoperative nausea and vomiting or chemotherapy-induced nausea and vomiting. Azasetron does not impair neutrophil chemotaxis or phagocytosis and does not scavenge O(-)(2) or H(2)O(2) generated by cell-free systems .
loading...
    loading...
View All Sizes
2-Methoxyestradiol-13C,d3
2-Methoxyestradiol-13C,d3
0 Images
Cat. No.: HY-12033S
CAS No.: 1217470-09-1
2-Methoxyestradiol- 13C,d3 is the 13C- and deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa [3] .
loading...
    loading...
View All Sizes
Deucravacitinib-13C,d3
Deucravacitinib-13C,d3
0 Images
Cat. No.: HY-166594S
Deucravacitinib- 13C,d3 is the 13C- and deuterium labeled Deucravacitinib. Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases, which selectively binds to TYK2 pseudokinase (JH2) domain (IC50=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain. Deucravacitinib inhibits IL-12/23 and type I IFN pathways. Deucravacitinib, the FDA's world first de novo deuterium, is available for study in moderate to severe plaque psoriasis .
loading...
    loading...
View All Sizes
Clindamycin-13C,d3
Clindamycin-13C,d3
0 Images
Cat. No.: HY-B1455S1
CAS No.: 2140264-63-5
Clindamycin- 13C,d3 is the 13C- and deuterium labeled Clindamycin. Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria [3].
loading...
    loading...
View All Sizes
AMG-424
AMG-424
0 Images
Cat. No.: HY-P991461
Synonyms: XmAb968

Target:  

CD38

Research Areas:  

Cancer

AMG-424 (XmAb968) is a human bispecific antibody (bsAb) targeting CD38 & CD3E. AMG-424 kills CD38-expressing cancer cells, triggers T-cell proliferation and attenuates cytokine release. AMG 424 has antitumor activity in a bone marrow-invasive mouse cancer model and induces peripheral B-cell depletion in cynomolgus monkeys. AMG-424 can be used in multiple myeloma research. Recommended isotype control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3 .
loading...
    loading...
View All Sizes
Idebenone-13C,d3
Idebenone-13C,d3
0 Images
Cat. No.: HY-W777283
CAS No.: 1189907-75-2
Idebenone- 13C,d3 is the deuterium labeled and 13C-labeled Idebenone (HY-N0303). Idebenone, a well-appreciated mitochondrial protectant, exhibits protective efficacy against neurotoxicity and can be used for the research of Alzheimer's disease, Huntington's disease. Idebenone (oxidised form) has a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid in astroglial homogenates (IC50=16.65 μM) . Idebenone, a coenzyme Q10 analog and an antioxidant, induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells . Idebenone quickly crosses the blood-brain barrier.
loading...
    loading...
View All Sizes
S101
S101
0 Images
Cat. No.: HY-165526
CAS No.: 362508-67-6
Target:  

Aryl Hydrocarbon Receptor Apoptosis TNF Receptor

Research Areas:  

Inflammation/Immunology

S101 is an inhibitor of SLP-76 and AhR. By inhibiting SLP-76 phosphorylation, S101 blocks the TCR signaling pathway and prevents AhR nuclear translocation, thereby selectively suppressing the proliferation of activated T cells, inducing their apoptosis, and reducing TNF-α levels. S101 can be used in studies of graft rejection, psoriasis, and superantigen-induced toxic shock .
loading...
    loading...
View All Sizes
Octinoxate-13C,d3
Octinoxate-13C,d3
0 Images
Cat. No.: HY-B1234S
Octinoxate-13C,d3 is the deuterium labeled Octinoxate (HY-W245806). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo [3] .
loading...
    loading...
View All Sizes
Assay Types