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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
167 Results for "
Fibronectin
" in MedChemExpress (MCE) Product Catalog:
Products (167)
167 Results for "Fibronectin" in MCE Product Catalog:
Cat. No.: HY-P5812
CAS No.: 1224095-25-3
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MT-4 is a derivative of a tissue transglutaminase (TG2) inhibitor. MT-4 targets the complex of TG2 and fibronectin (FN) (TG2/FN) and inhibits the adhesion of tumor cells to the matrix. MT-4 inhibits the adhesion of ovarian cancer (OC) cells to the peritoneum and increases the sensitivity of OC cells to paclitaxel.
Cat. No.: HY-P990654
CAS No.: 1253180-81-2
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Cat. No.: HY-102073
CAS No.: 946369-04-6
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TG53 is a potent inhibitor of tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction. TG53 inhibits formation of a complex with integrin β1 and activation of FAK and c-Src during SKOV3 cell attachment onto FN. TG53 can be used for ovarian cancer research .
Cat. No.: HY-P1076A
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Cat. No.: HY-P0314A
CAS No.: 2171504-22-4
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Cat. No.: HY-P1816
CAS No.: 136466-51-8
Cat. No.: HY-177739
CAS No.: 1590409-23-6
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Antifibrotic agent 2 (Compound 636) is a polycyclic pyridinone derivative with antifibrotic activity. Antifibrotic agent 2 reduces the pathological accumulation of fibrosis-related proteins such as fibronectin and collagen, prevents excessive fibrous connective tissue from depositing in organs or tissues, and reverses or delays the remodeling of tissue fibrosisby regulating the abnormal proliferation and activation of fibroblasts. Antifibrotic agent 2 can be used for research on pulmonary fibrosis .
Cat. No.: HY-155643
CAS No.: 3033465-55-0
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PROTAC TG2 degrader-1 is a tissue transglutaminase (TG2) PROTAC degrader with a Kd of 68.9 μM. PROTAC TG2 degrader-1 recruits the VHL E3 ubiquitin ligase to the fibronectin-binding site of TG2, forms a ternary complex, and induces proteasome-dependent degradation of TG2. PROTAC TG2 degrader-1 inhibits ovarian cancer cell migration and adhesion to fibronectin, without producing a significant inhibitory effect on cell proliferation. PROTAC TG2 degrader-1 can be used in related research on ovarian cancer .
Cat. No.: HY-16141R
CAS No.: 188968-51-6
Synonyms: EMD 121974 (Standard)
Cilengitide (Standard) (EMD 121974 (Standard)) is the analytical standard of Cilengitide (HY-16141). This product is intended for research and analytical applications. Cilengitide (EMD 121974) is an integrin (integrin) inhibitor with blood-brain barrier permeability, with IC50 values against human targets as follows: 0.61 nM for αvβ3, 8.4 nM for αvβ5, 14.9 nM for α5β1, 5400 nM for αIIbβ3, 2050 nM for αvβ6, 2350 nM for αvβ8. Cilengitide inhibits the binding of integrins to vitronectin, fibronectin, fibrinogen and LAP (TGF-β), and serves as an internal standard for solid-phase integrin binding assays. Cilengitide inhibits tumor cell viability, induces apoptosis, reduces the phosphorylation levels of STAT3, AKT and mTOR, downregulates the expression of PD-L1, inhibits cell viability and angiogenesis, regulates anti-tumor immune responses and slows tumor growth. Cilengitide can be used in research related to glioblastoma, melanoma, advanced solid tumors and refractory brain tumors .
Cat. No.: HY-P0314
CAS No.: 109292-46-8
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Synonyms: E6007
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Milategrast is useful as cell adhesion inhibitor or cell infiltration inhibitor. Milategrast in vitro inhibites the adhesion of Jurkat cells to human fibronectin with an IC50 of ＜5 μM .
Cat. No.: HY-170601
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PROTAC JNK1 Degrader-1 is a JNK1 PROTAC degrader with a DC50 of 10 nM. PROTAC JNK1 Degrader-1 reduces the level of fibronectin. PROTAC JNK1 Degrader-1 can be used for the research of pulmonary fibrosis .
Cat. No.: HY-106979
CAS No.: 186752-78-3
Synonyms: SAR-943
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Olcorolimus (SAR-943) is a Rapamycin (HY-10219) derivative. Olcorolimus can reduce IL-4, IL-5, eosinophil, neutrophil, lymphocyte, cellular fibronectin; lung epithelial cell proliferation and mucus hypersecretory phenotype in Ovalbumin (HY-W250978)-sensitized BALB/c mice. Olcorolimus can be used for the researches of inflammation and immunology, such as asthma .
Cat. No.: HY-P10984
CAS No.: 206536-96-1
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Cat. No.: HY-P2719
CAS No.: 107978-77-8
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Cat. No.: HY-P1897
CAS No.: 97461-84-2
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Cat. No.: HY-P2635
CAS No.: 91575-25-6
Cat. No.: HY-P0306A
Synonyms: Heparin Binding Peptide TFA
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Cat. No.: HY-P3520
CAS No.: 97461-82-0
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
