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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
244 Results for "
Notch
" in MedChemExpress (MCE) Product Catalog:
Products (244)
244 Results for "Notch" in MCE Product Catalog:
BMS-983970 is an oral pan-Notch inhibitor for the treatment of multiplecancers .
Cat. No.: HY-RS09451
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NOTCH3 Human Pre-designed siRNA Set A contains three designed siRNAs for NOTCH3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-15211
CAS No.: 623165-93-5
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MRK 003 is an orally active γ-secretase inhibitor. MRK 003 targets the Notch signaling pathway by blocking the proteolytic cleavage of Notch receptors. MRK 003 inhibits tumor cell proliferation, induces apoptosis, downregulates anti-apoptotic proteins, upregulates phosphorylated Akt, suppresses angiogenesis, and overcomes microenvironment-mediated proliferative protection. MRK 003 can be used in research related to lung cancer, multiple myeloma, non-Hodgkin's lymphoma, pancreatic ductal adenocarcinoma, glioblastoma, and breast cancer .
Cat. No.: HY-158012
CAS No.: 2064292-78-8
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LY3056480 is a γ-secretase inhibitor. LY3056480 inhibits the Notch signaling pathway, upregulates Atoh1, promotes hair cell regeneration, and drives supporting cell transdifferentiation. LY3056480 is applicable to research related to sensorineural hearing loss .
Cat. No.: HY-P991423
Synonyms: 21H3RK
Cat. No.: HY-P1985A
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Cat. No.: HY-RS09445
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NOTCH1 Human Pre-designed siRNA Set A contains three designed siRNAs for NOTCH1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS09448
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NOTCH2 Human Pre-designed siRNA Set A contains three designed siRNAs for NOTCH2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19796
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Notch2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Notch2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-15185R
CAS No.: 1290543-63-3
Synonyms: PF-3084014 (Standard)
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Nirogacestat (Standard) is the analytical standard of Nirogacestat. This product is intended for research and analytical applications. Nirogacestat (PF-3084014) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers .
Cat. No.: HY-120372
CAS No.: 1584631-89-9
BMS-871 is an orally active pan-Notch inhibitor with IC50 values of 4/1/4/3 nM for Notch1/2/3/4, respectively. BMS-871 significantly inhibited the proliferation of TALL-1 and MDA-MB-157 cells and demonstrated significant antitumor activity in T-acute lymphoblastic leukemia and triple-negative breast cancer xenograft models. BMS-871 can be used to study leukemia and breast cancer .
Cat. No.: HY-164451
CAS No.: 362653-62-1
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GSI-18 is a γ-secretase inhibitor with anticancer activity. GSI-18 inhibits the attachment-free growth of pancreatic cancer cells by inhibiting Notch signaling .
Cat. No.: HY-RS09447
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Notch1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Notch1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-103538
CAS No.: 62252-26-0
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JLK-6 is a rhomboid protease GlpG inhibitor. JLK-6 reduces the production of Amyloid β-peptide by altering the cleavage of β-amyloid precursor protein by γ-secretase, with no effect on the cleavage of Notch receptors. JLK-6 can be used in research related to Alzheimer's disease .
Cat. No.: HY-E70292
Synonyms: GALNT11
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N-Acetylgalactosaminyltransferase 11 (GALNT11) is a glycosylation transferase capable of activating the Notch signal .
Cat. No.: HY-P990476
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Cat. No.: HY-P990177
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Cat. No.: HY-RS09446
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Notch1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Notch1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS09452
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NOTCH4 Human Pre-designed siRNA Set A contains three designed siRNAs for NOTCH4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
