62252-26-0
62252-26-0
Chemical Structure
JLK-6
- CAS No.: 62252-26-0
- Formula:C10H8ClNO3
- Molecular Weight:225.63
IUPAC Name: 7-amino-4-chloro-3-methoxy-1H-isochromen-1-one
InChIKey: AMDGKLWVCUXONP-UHFFFAOYSA-N
SMILES: O=C1C2=CC(N)=CC=C2C(Cl)=C(OC)O1
Biological Activity: JLK-6 is a rhomboid protease GlpG inhibitor. JLK-6 reduces the production of Amyloid β-peptide by altering the cleavage of β-amyloid precursor protein by γ-secretase, with no effect on the cleavage of Notch receptors. JLK-6 can be used in research related to Alzheimer's disease[1][2].
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JLK-6 | JLK-6 is a rhomboid protease GlpG inhibitor. JLK-6 reduces the production of Amyloid β-peptide by altering the cleavage of β-amyloid precursor protein by γ-secretase, with no effect on the cleavage of Notch receptors. JLK-6 can be used in research related to Alzheimer's disease. | |||||||||||||||||||||
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References
- [1]. Peuchmaur M, et al. Further characterization of a putative serine protease contributing to the γ-secretase cleavage of β-amyloid precursor protein. Bioorganic & medicinal chemistry. 2013 Feb 15;21(4):1018-29. [Content Brief]
- [2]. Goel P, et al. Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases. Biochemistry. 2017 Dec 26;56(51):6713-6725. [Content Brief]
Keywords
