1. Neuronal Signaling
    Stem Cell/Wnt
  2. Notch
  3. BMS-983970

BMS-983970 

Cat. No.: HY-12419 Purity: 99.42%
Handling Instructions

BMS-983970 is an oral pan-Notch inhibitor for the treatment of multiplecancers.

For research use only. We do not sell to patients.

BMS-983970 Chemical Structure

BMS-983970 Chemical Structure

CAS No. : 1584713-87-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 479 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 479 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BMS-983970 is an oral pan-Notch inhibitor for the treatment of multiplecancers[1].

IC50 & Target

Notch[1]

In Vivo

BMS-983970 demonstrates anti-tumor activity in T-cell acute lymphoblastic leukemia (T-ALL) and solid tumor xenograft models[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

518.50

Formula

C26H26F4N4O3

CAS No.
SMILES

O=C(N[[email protected]@H]1C(NC2=C(F)C=CC=C2C(C3=CC=CC=C3)=N1)=O)[[email protected]](CCC(F)(F)F)[[email protected]](CC4CC4)C(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (96.43 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9286 mL 9.6432 mL 19.2864 mL
5 mM 0.3857 mL 1.9286 mL 3.8573 mL
10 mM 0.1929 mL 0.9643 mL 1.9286 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (4.82 mM); Suspended solution; Need ultrasonic and warming

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (4.82 mM); Suspended solution; Need ultrasonic and warming

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.82 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.42%

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Product Name:
BMS-983970
Cat. No.:
HY-12419
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