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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
244 Results for "
Notch
" in MedChemExpress (MCE) Product Catalog:
Products (244)
244 Results for "Notch" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P78009
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: Notch3; Notch 3-Like Protein; Prev. CADASIL; CADASIL1; Notch 3; CARASIL1; CASIL; FPLD1; Neurogenic Locus Notch Homolog Protein 3; IMF2; Notch (Drosophila) Homolog 3; LMNS; Notch Homolog 3 (Drosophila); Notch Receptor 3; Notch Homolog 3
Species:
Human
Source:
HEK293
1
1 Cited Publications
Target:
Research Areas:
ZLDI-8 is a Notch activating/cleaving enzyme ADAM-17 inhibitor and inhibits the cleavage of Notch protein. ZLDI-8 decreases the expression of pro-survival/anti-apoptosis and epithelial-mesenchymal transition (EMT) related proteins. ZLDI-8 is also a competitive and irreversible tyrosine phosphatase (Lyp) inhibitor with an IC50 of 31.6 μM and a Ki of 26.22 μM. ZLDI-8 inhibits the growth of MHCC97-H cells with an IC50 of 5.32 μM .
1
1
1
1 Cited Publications
JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity .
1
1 Cited Publications
Target:
Research Areas:
IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A .
1
1 Cited Publications
Synonyms: CHF5074; CSP-1103
Target:
Research Areas:
Itanapraced (CHF5074) is an orally active γ-secretase modulator and a non-steroidal anti-inflammatory derivative. Itanapraced reduces Aβ42 and Aβ40 secretion with IC50 values of 3.6 and 18.4 μM, respectively. Itanapraced inhibits cell apoptosis of hippocampal neurons induced by oxygen and glucose deprivation (OGD). Itanapraced can be used for the research of Alzheimer's disease .
1
1 Cited Publications
Synonyms: VPA-d4; 2-Propylpentanoic acid-d4
1
1 Cited Publications
Cat. No.: HY-N2830
CAS No.: 21499-24-1
1
1 Cited Publications
Cat. No.: HY-P70399
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: JAG1; Jagged 1; Prev. JAGL1; Alagille Syndrome; Prev. AGS; Jagged-1 Protein; HJ1; CD339 Antigen; CD339; Jagged1; AHD; CMT2HH; AWS; AGS1; Protein Jagged-1; DCHE; Jagged Canonical Notch Ligand 1; Delta-Like Protein
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P71633
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: JAG1; Jagged 1; Prev. JAGL1; Alagille Syndrome; Prev. AGS; Jagged-1 Protein; HJ1; CD339 Antigen; CD339; Jagged1; AHD; CMT2HH; AWS; AGS1; Protein Jagged-1; DCHE; Jagged Canonical Notch Ligand 1; Delta-Like Protein
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P73258
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: JAG1; Jagged 1; Prev. JAGL1; Alagille Syndrome; Prev. AGS; Jagged-1 Protein; HJ1; CD339 Antigen; CD339; Jagged1; AHD; CMT2HH; AWS; AGS1; Protein Jagged-1; DCHE; Jagged Canonical Notch Ligand 1; Delta-Like Protein
Species:
Human
Source:
HEK293
Cat. No.: HY-P99258
CAS No.: 1447814-75-6
Synonyms: OMP 52M51; Anti-Human Notch1 Recombinant Antibody
Cat. No.: HY-18614
CAS No.: 209984-68-9
Target:
Research Areas:
LY900009 is a potent and orally active, First-in-class inhibitor of Notch signaling via selective inhibition of the γ-secretase protein (GSI). LY900009 inhibits Notch signalling in tumor cell lines and endothelial cells (IC50=0.005-20 nM). LY900009 can be used for advanced cancer research .
Cat. No.: HY-P99320
CAS No.: 1359940-55-8
Synonyms: OMP 59R5; Anti-Human Notch2 Recombinant Antibody
Synonyms: VPA (Standard); 2-Propylpentanoic acid (Standard); Dipropylacetic acid (Standard)
Target:
Reference Standards Organoid HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite
Research Areas:
Valproic acid (Dipropylacetic Acid) (Standard) is an analytical standard for valproic acid. This product is intended for research and analytical applications. Valproic acid is an orally active HDAC inhibitor (IC50=0.5-2 mM), inhibits the activity of HDAC1 (IC50=400 μM), and induces the degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits the proliferation of small cell lung cancer (SCLC) cells. Valproic acid is used in the study of epilepsy, bipolar disorder, metabolic diseases, HIV infection, and migraine .
ASR-490 reduces the viability of HCT116 and SW620 cells by downregulating Notch1 signaling. ASR-490 overcomes Notch1 overexpression and inhibits the growth of HCT/Notch1 transfectants. ASR-490 inhibits the tumor growth in control (pCMV/HCT116) and Notch1/HCT116 in xenotransplanted mice .
Cat. No.: HY-164404
CAS No.: 2503017-11-4
NADI-351 is an orally active and potent Notch1 inhibitor that selectively disrupts Notch1 transcription complexes and reduces Notch1 recruitment to target genes. NADI-351 can be utilized in cancer research .
Cat. No.: HY-N1510
CAS No.: 22149-35-5
Cat. No.: HY-P1985
CAS No.: 2408730-51-6
Target:
Research Areas:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
