21499-24-1
Chemical Structure
Agrimonolide
- CAS No.: 21499-24-1
- Formula:C18H18O5
- Molecular Weight:314.33
IUPAC Name: (S)-6,8-dihydroxy-3-(4-methoxyphenethyl)isochroman-1-one
InChIKey: TYFJTEPDESMEHE-HNNXBMFYSA-N
SMILES: O=C1C2=C(O)C=C(O)C=C2C[C@H](CCC3=CC=C(OC)C=C3)O1
Biological Activity: Agrimonolide is a phenethyl isocoumarin compound discovered from Agrimonia pilosa, exhibiting anti-inflammatory, antioxidant, and anticancer activities. Agrimonolide inhibits NF-κB, MAPK, and TLR4-mediated neuroinflammatory signaling, suppresses Notch and JAK2/STAT3 signaling to modulate Th17/Treg balance and maintain the intestinal barrier. Agrimonolide decreases HIF1A expression, inhibits glycolysis, and induces ferroptosis and cell cycle arrest via the mTOR pathway in tumor models, thereby suppressing cancer cell viability, proliferation, and metastasis. Agrimonolide exerts hepatoprotective and anti-fibrotic effects by regulating bile acid transporter expression and reducing hepatic bile acid accumulation. Agrimonolide is used for research on ulcerative colitis, ovarian cancer, non-small cell lung cancer, cholestatic liver injury, and neuroinflammation[1][2][3][4][5][6].
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Agrimonolide | 98% | Agrimonolide is a phenethyl isocoumarin compound discovered from Agrimonia pilosa, exhibiting anti-inflammatory, antioxidant, and anticancer activities. Agrimonolide inhibits NF-κB, MAPK, and TLR4-mediated neuroinflammatory signaling, suppresses Notch and JAK2/STAT3 signaling to modulate Th17/Treg balance and maintain the intestinal barrier. Agrimonolide decreases HIF1A expression, inhibits glycolysis, and induces ferroptosis and cell cycle arrest via the mTOR pathway in tumor models, thereby suppressing cancer cell viability, proliferation, and metastasis. Agrimonolide exerts hepatoprotective and anti-fibrotic effects by regulating bile acid transporter expression and reducing hepatic bile acid accumulation. Agrimonolide is used for research on ulcerative colitis, ovarian cancer, non-small cell lung cancer, cholestatic liver injury, and neuroinflammation. | ||||||||||||||||||||
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References
- [1]. Jiang J, et al. Agrimonolide mitigated DSS-induced colitis by modulating the balance between Treg and Th17 cells through the suppression of the Notch and JAK2/STAT3 signaling pathways. Heliyon. 2024 Jul 15;10(13):e33803. [Content Brief]
- [2]. Yang Y, et al. Agrimonolide inhibits glycolysis in ovarian cancer cells by regulating HIF1A. Mutation research. 2024;829:111884.
- [3]. Zhang X, et al. Agrimonolide Inhibits the Malignant Progression of Non-small Cell Lung Cancer and Induces Ferroptosis through the mTOR Signaling Pathway. Anticancer Agents Med Chem. 2024;24(18):1371-1381.
- [4]. Han L, et al. Agrimonolide from Agrimonia pilosa Ledeb attenuates cholestatic liver injury and macrophage infiltration via the inhibition of bile acid excretion transporters. International immunopharmacology. 2025 Nov 14;165:115186.
- [5]. Kim HW, et al. Acylphloroglucinolated Catechin and Phenylethyl Isocoumarin Derivatives from Agrimonia pilosa. J Nat Prod. 2016 Sep 23;79(9):2376-83. [Content Brief]
- [6]. Li W, et al. Agrimonolide exhibits anti-neuroinflammatory potential via TLR4-mediated pathways. Molecular and cellular neurosciences. 2025 Dec;135:104057.
