Pteris wallichiana Agardh

Agrimonolide is a phenethyl isocoumarin compound discovered from Agrimonia pilosa, exhibiting anti-inflammatory, antioxidant, and anticancer activities. Agrimonolide inhibits NF-κB, MAPK, and TLR4-mediated neuroinflammatory signaling, suppresses Notch and JAK2/STAT3 signaling to modulate Th17/Treg balance and maintain the intestinal barrier. Agrimonolide decreases HIF1A expression, inhibits glycolysis, and induces ferroptosis and cell cycle arrest via the mTOR pathway in tumor models, thereby suppressing cancer cell viability, proliferation, and metastasis. Agrimonolide exerts hepatoprotective and anti-fibrotic effects by regulating bile acid transporter expression and reducing hepatic bile acid accumulation. Agrimonolide is used for research on ulcerative colitis, ovarian cancer, non-small cell lung cancer, cholestatic liver injury, and neuroinflammation.

Pteroside M (Conpound 3) is a pterosin found in Pteris wallichiana J. Agardh.

Vellosimine ((+)-Vellosimine) is an indole alkaloid. Vellosimine acts as a plant metabolite.

(2S,3S)-Pterosin C is a natural sesquiterpenoid compound.

Wallichoside is a sesquiterpene that can be isolated from Pteris wallichiana.