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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
(±)14,15-EET
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "(±)14,15-EET" in MCE Product Catalog:
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1 Cited Publications
Cat. No.: HY-120954
CAS No.: 519038-92-7
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14,15-EE-5(Z)-E is a structural analogue of 14, 15-epoxide dicartrienoic acid (14,15-EET). 14,15-EE-5(Z)-E antagonizes the relaxation of vascular smooth muscle induced by EET .
Synonyms: (±)14(15)-EET
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Cat. No.: HY-139961S
CAS No.: 2699608-29-0
Cat. No.: HY-139937S
Cat. No.: HY-131721
CAS No.: 218461-97-3
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14,15-EET-SI is a sulfonimide (SI) analog metabolized from 14,15-EET, which is also an effective mitogen. 14,15-EET-SI can stimulate the incorporation of [3H] thymidine, activate pp60c-src and initiate the tyrosine kinase cascade, mediating their mitotic effects. Additionally, 14,15-EET-SI can increase cell proliferation as well as the expression of c-fos and egr-1 mRNA .
Cat. No.: HY-165005A
CAS No.: 70219-56-6
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(±) 14 (15)-EET Methyl ester (Compound 14,15-EET-Me) is a 14,15-EET (HY-113489) analog and vasodilatory agonist. (±) 14 (15)-EET Methyl ester induces relaxation of precontracted bovine coronary arteries .
Cat. No.: HY-175044
CAS No.: 1469713-10-7
Synonyms: (±)14(15)-Epoxy eicosatrienoyl ethanolamide
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(±)14(15)-EET Ethanolamide ((±)14(15)-Epoxy eicosatrienoyl ethanolamide) is a fatty acid monoepoxide. (±)-14(15)-EET ethanolamide can be used in the research of Pseudomonas aeruginosa infections and respiratory diseases .
Cat. No.: HY-CE00870
CAS No.: 2245272-22-2
Synonyms: 14,15-Epoxy-(5Z,8Z,11Z)-eicosatrienoyl-coenzyme A
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14,15-EET-CoA (14,15-Epoxy-(5Z,8Z,11Z)-eicosatrienoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
Cat. No.: HY-143664
Synonyms: (±)14,15-DiHETrE
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(±)14(15)-DiHET ((±)14,15-DiHETrE) is an epoxide hydrolases enzymatically hydrated metabolite of (±)14(15)-EET .
Cat. No.: HY-143664S
Purity: ≥95.0%
Synonyms: (±)14,15-DiHETrE-d11
Cat. No.: HY-165067
CAS No.: 519038-93-8
Synonyms: 14,15-Epoxyeicosa-8(Z)-enoic acid
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14,15-EE-8(Z)-E (14,15-Epoxyeicosa-8(Z)-enoic acid) has potent vasodilator agonist activity in bovine coronary arteries. 14,15-EE-8(Z)-E is a 14,15-EET (HY-113489) analog. EETs represent important mediators of coronary vascular tone .
Cat. No.: HY-139002
CAS No.: 2428734-45-4
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CYP4Z1-IN-2 (compound 7) is a reversible inhibitor of CYP4Z1 (Ki=2.2 μM), which inhibits the production of 14,15-EET in breast cancer cells. CYP4Z1-IN-2 inhibits the CYP4Z1-mediated Luc-BE O-debenzylation reaction with an IC50 of 5.9 μM .
Cat. No.: HY-N12970
CAS No.: 105304-92-5
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Cat. No.: HY-183844
CAS No.: 2792206-44-9
Research Areas:
C5F2-HCB is a CYP-mediated inhibitor of the biosynthesis of arachidonic acid epoxygenase product (±) 14,15-EET (HY-150084), with an IC50 of 3.1 μM. C5F2-HCB inhibits EET-driven oxidative phosphorylation (OXPHOS) associated with tumor hypoxia, converting an immunologically "cold" tumor microenvironment into a "hot" one. C5F2-HCB reverses the immune-excluded tumor microenvironment in ER +HER2 − breast cancer allograft models. C5F2-HCB can be used in research related to ER +HER2 − breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
