218461-97-3
Chemical Structure
14,15-EET-SI
- CAS No.: 218461-97-3
- Formula:C21H35NO4S
- Molecular Weight:397.57
IUPAC Name: (5Z,8Z,11Z)-N-(methylsulfonyl)-13-(3-pentyloxiran-2-yl)trideca-5,8,11-trienamide
InChIKey: UPGGGACSUDOHOT-PHTXUDHCSA-N
SMILES: CS(NC(CCC/C=C\C/C=C\C/C=C\CC1C(O1)CCCCC)=O)(=O)=O
Biological Activity: 14,15-EET-SI is a sulfonimide (SI) analog metabolized from 14,15-EET, which is also an effective mitogen. 14,15-EET-SI can stimulate the incorporation of [3H] thymidine, activate pp60c-src and initiate the tyrosine kinase cascade, mediating their mitotic effects. Additionally, 14,15-EET-SI can increase cell proliferation as well as the expression of c-fos and egr-1 mRNA[1].
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14,15-EET-SI | 14,15-EET-SI is a sulfonimide (SI) analog metabolized from 14,15-EET, which is also an effective mitogen. 14,15-EET-SI can stimulate the incorporation of [3H] thymidine, activate pp60c-src and initiate the tyrosine kinase cascade, mediating their mitotic effects. Additionally, 14,15-EET-SI can increase cell proliferation as well as the expression of c-fos and egr-1 mRNA. | |||||||||||||||||||||
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