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Results for "

α,β-unsaturated

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aldehyde Dehydrogenase (ALDH) (3) Bacterial (5) Biochemical Assay Reagents (5) CDK (1) Drug Derivative (2) Drug Intermediate (1) Drug Isomer (2) Endogenous Metabolite (7) Environmental Pollutants (1) Fungal (1) HIV (2) Isotope-Labeled Compounds (4) Microtubule/Tubulin (1) Reference Standards (4)
By Research Areas:	Cancer (7) Cardiovascular Disease (3) Infection (9) Metabolic Disease (5) Neurological Disease (4)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113466

4-Hydroxynonenal 15+ Cited Publications 4-HNE	Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite	Cardiovascular Disease Neurological Disease Cancer
4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria .

HY-Y1644

(E)-Crotonic acid 1 Publications Verification (E)-2-Butenoic acid; trans-2-Butenoic acid; trans-Crotonic acid	Endogenous Metabolite	Metabolic Disease
NSC 8751 (trans-2-Butenoic acid; trans-Crotonic acid) is an unsaturated carboxylic acid compound containing α,β-unsaturated carboxylic acid groups. NSC 8751 is one of the important analogs for evaluating the safety of fragrance ingredients and is used to evaluate the toxicological properties of compounds with similar structures. When NSC 8751 is applied to local lymph nodes, a 50% concentration does not cause skin sensitization. Structural analogs of NSC 8751 have been shown to be non-genotoxic. trans-Crotonic acid can be used in the preparation of cosmetics and food additives .

HY-116446

Pironetin	Microtubule/Tubulin	Cancer
Pironetin is an α/β unsaturated lactone isolated from Streptomyces species. Pironetin binds to α-tubulin and is a potent inhibitor of microtubule polymerization, and has cell cycle arrest and antitumor activity .

HY-134635

Dehydrozingerone	Bacterial Fungal HIV CDK	Infection Cancer
Dehydrozingerone is a ginger-derived component and cyclin D1 inhibitor that downregulates cyclin D1 expression and induces cell cycle G₁ phase arrest. Dehydrozingerone reduces the proliferative capacity of castration-resistant prostate cancer cells under in vitro conditions. Dehydrozingerone reduces subcutaneous tumor growth by inhibiting cell proliferation and angiogenesis. Dehydrozingerone exerts antibacterial and antifungal activities via its α,β-unsaturated carbonyl conjugated system. Dehydrozingerone can be used in studies related to castration-resistant prostate cancer, bacterial infections, and food spoilage fungal infections .

HY-Y1634

4-Hydroxy-6-methyl-2-pyrone	Biochemical Assay Reagents	Others
4-Hydroxy-6-methyl-2-pyrone is an organic reagent that reacts with αβ-unsaturated acyl chlorides .

HY-113466S

4-Hydroxynonenal-d3 4-HNE-d₃	Isotope-Labeled Compounds Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite	Cardiovascular Disease Neurological Disease Cancer
4-Hydroxynonenal-d₃ is the deuterium labeled 4-Hydroxynonenal. 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria .

HY-Y0932

Isophorone	Environmental Pollutants	Others
Isophorone, an α,β-unsaturated cyclic ketone, is used as a precursor to polymers .

HY-133022

trans-2-Undecenoic acid (E)-2-Undecenoic acid; (E)-Undec-2-enoic acid	Drug Isomer	Metabolic Disease
trans-2-Undecenoic acid ((E)-2-Undecenoic acid) is an α,β-unsaturated carboxylic acid and is characterized by acid dimers. The corresponding dimers are connected via intermolecular hydrogen bonds of the carboxylic groups C=O···H-O .

HY-W014352

trans-4-Bromocinnamaldehyde	Drug Derivative	Infection
trans-4-Bromocinnamaldehyde (Compound 6d) is an (E)-α,β-unsaturated aldehyde and cinnamaldehyde derivative. trans-4-Bromocinnamaldehyde serves as a starting material for the synthesis of α-aryl substituted phosphinomycin analogs. trans-4-Bromocinnamaldehyde can be used in the research of tuberculosis .

HY-120893

trans-4,5-Epoxy-(E)-2-decenal	Endogenous Metabolite	Others
trans-4,5-Epoxy-(E)-2-decenal is an oxygenated α,β-unsaturated aldehyde found in mammalian blood that gives blood its characteristic metallic odor. It is used by predators to locate blood or prey .

HY-Y0932S

Isophorone-d5	Isotope-Labeled Compounds	Others
Isophorone-d₅ is the deuterium labeled Isophorone. Isophorone, an α,β-unsaturated cyclic ketone, is used as a precursor to polymers .

HY-Y0932S1

Isophorone-d8	Isotope-Labeled Compounds	Others
Isophorone-d₈ is the deuterium labeled Isophorone . Isophorone, an α,β-unsaturated cyclic ketone, is used as a precursor to polymers .

HY-N10391

(-)-Cleistenolide Cleistenolide	Bacterial	Infection Cancer
(-)-Cleistenolide is a α,β-unsaturated δ-lactone isolated from Cleistochlamys kirkii Oliver. (-)-Cleistenolide has antibacterial and antitumor activity .

HY-Y0932R

Isophorone (Standard)	Biochemical Assay Reagents Reference Standards	Others
Isophorone (Standard) is the analytical standard of Isophorone. This product is intended for research and analytical applications. Isophorone, an α,β-unsaturated cyclic ketone, is used as a precursor to polymers .

HY-N16010

4-HNE-Dimethylacetal	Biochemical Assay Reagents	Others
4-HNE-Dimethylacetal is an α,β-unsaturated hydroxyalkenal that can be produced by lipid peroxidation in cells. 4-HNE-Dimethylacetal can be studied in research on cell signal transduction including pathways from cell cycle events to cellular adhesion .

HY-133022R

trans-2-Undecenoic acid (Standard) (E)-2-Undecenoic acid (Standard); (E)-Undec-2-enoic acid (Standard)	Reference Standards Drug Isomer	Metabolic Disease
trans-2-Undecenoic acid (Standard) is the analytical standard of trans-2-Undecenoic acid. This product is intended for research and analytical applications. trans-2-Undecenoic acid ((E)-2-Undecenoic acid) is an α,β-unsaturated carboxylic acid and is characterized by acid dimers. The corresponding dimers are connected via intermolecular hydrogen bonds of the carboxylic groups C=O···H-O[1].

HY-N7860

Δ2-cis Eicosenoic acid	Others	Infection
Δ2-cis Eicosenoic acid is an α,β-unsaturated fatty acid that has been extracted from fresh water clams and purified. A related compound, 2-octadecenoic acid, has been shown to improve liver function and decrease blood sugar in streptozocin-induced diabetic rats. Δ2-cis Eicosenoic acid and its salts have potential medicinal use for treating diabetes and improving lipid metabolism.

HY-Y0191R

α-Pyridone (Standard) 2-Pyridone (Standard)	Reference Standards Endogenous Metabolite Bacterial	Infection Metabolic Disease
α-Pyridone (Standard) is the analytical standard of α-Pyridone. This product is intended for research and analytical applications. α-Pyridone (2-Pyridone) is an antibacterial agent. α-Pyridone can be synthesized via the 1,4-addition of 2-(phenylsulfinyl)acetamide to α,β-unsaturated ketones followed by cyclization and sulfoxide elimination. α-Pyridone can also be used to synthesize a wide range of heterocyclic compounds .

HY-113466R

4-Hydroxynonenal (Standard) 4-HNE (Standard)	Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite Reference Standards	Cardiovascular Disease Neurological Disease Cancer
4-Hydroxynonenal (Standard) is the analytical standard of 4-Hydroxynonenal. This product is intended for research and analytical applications. 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria .

HY-W587725

Drotaveraldine	Drug Intermediate	Others
Drotaveraldine is a compound undergoes a domino reaction with α,β-unsaturated aldehydes. Drotaveraldine can be reacted to generate pyrrolo[2,1-a]isoquinoline .

HY-13211A

2-Decenoic acid	Biochemical Assay Reagents	Infection
2-Decenoic acid is an α,β-unsaturated fatty acid that inhibits plant pollen germination and pollen tube elongation processes. 2-Decenoic acid is promising for research of plant reproductive biology and antifungal/antibacterial agents .

HY-W012346

Geranyl isobutyrate	Drug Derivative Bacterial	Infection
Geranyl isobutyrate is a synthetic α,β‑unsaturated branched‑chain aliphatic ester and a geraniol derivative. Geranyl isobutyrate acts as a food and feed flavouring agent and a biologically active antimicrobial compound. Geranyl isobutyrate shows antimicrobial activity against Gram‑positive and most Gram‑negative bacteria .

HY-N16821

Hydroxydihydrobovolide	HIV	Infection Neurological Disease
Hydroxydihydrobovolide is a α-β-unsaturatedγ-lactone found in Portulaca oleracea L.. Hydroxydihydrobovolide shows cytotoxicity against cancer cells and shows anti-HIV-1 activity (IC₅₀ = 122.7 μM). Hydroxydihydrobovolide can be used for the researches of neuroblastoma and HIV-1 infection .

HY-W697750

trans-2-Methyl-2-butenal Tiglaldehyde	Biochemical Assay Reagents	Cancer
trans-2-Methyl-2-butenal (Tiglaldehyde) is an adduct former that can be found in cigarette smoke, and very weakly inhibits growth of cancer cells and normal mouse cells. trans-2-Methyl-2-butenal forms adducts with glutathione (GSH) via Michael addition.trans-2-Methyl-2-butenal is an α,β-unsaturated carbonyl compound .

HY-Y0191S

α-Pyridone-d5 2-Pyridone-d₅	Isotope-Labeled Compounds Bacterial Endogenous Metabolite	Infection Metabolic Disease
α-Pyridone-d₅ (2-Pyridone-d₅) is the deuterium labeled α-Pyridone (HY-Y0191). α-Pyridone (2-Pyridone) is an antibacterial agent. α-Pyridone can be synthesized via the 1,4-addition of 2-(phenylsulfinyl)acetamide to α,β-unsaturated ketones followed by cyclization and sulfoxide elimination. α-Pyridone can also be used to synthesize a wide range of heterocyclic compounds .

Cat. No.	Product Name

HY-L926

Cysteine Protease Focused Covalent Library	2,113 compounds
Cysteine proteases (CPs), a key enzyme family regulating physiological metabolism and mediating pathological processes (e.g., abnormal bone resorption, tumour invasion, and pathogen infection), represent a core therapeutic target for disease intervention via the development of specific inhibitors. Currently reported CP covalent inhibitors encompass diverse structural types, including epoxides, aziridine, and activated double bonds (vinyl sulphones, α,β-unsaturated ketones), providing clear structural references for the development of novel CP covalent inhibitors. This compound library contains multiple warheads that specifically target cysteine proteases, serving as a powerful tool for the efficient discovery of novel covalent inhibitors against this enzyme family.

Cysteine Protease Focused Covalent Library

2,113 compounds

Cysteine proteases (CPs), a key enzyme family regulating physiological metabolism and mediating pathological processes (e.g., abnormal bone resorption, tumour invasion, and pathogen infection), represent a core therapeutic target for disease intervention via the development of specific inhibitors. Currently reported CP covalent inhibitors encompass diverse structural types, including epoxides, aziridine, and activated double bonds (vinyl sulphones, α,β-unsaturated ketones), providing clear structural references for the development of novel CP covalent inhibitors.

This compound library contains multiple warheads that specifically target cysteine proteases, serving as a powerful tool for the efficient discovery of novel covalent inhibitors against this enzyme family.

4-Hydroxy-6-methyl-2-pyrone	Biochemical Assay Reagents
4-Hydroxy-6-methyl-2-pyrone is an organic reagent that reacts with αβ-unsaturated acyl chlorides .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113466

4-Hydroxynonenal 15+ Cited Publications 4-HNE	Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer	Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite
4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria .

HY-Y1644

(E)-Crotonic acid 1 Publications Verification (E)-2-Butenoic acid; trans-2-Butenoic acid; trans-Crotonic acid	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
NSC 8751 (trans-2-Butenoic acid; trans-Crotonic acid) is an unsaturated carboxylic acid compound containing α,β-unsaturated carboxylic acid groups. NSC 8751 is one of the important analogs for evaluating the safety of fragrance ingredients and is used to evaluate the toxicological properties of compounds with similar structures. When NSC 8751 is applied to local lymph nodes, a 50% concentration does not cause skin sensitization. Structural analogs of NSC 8751 have been shown to be non-genotoxic. trans-Crotonic acid can be used in the preparation of cosmetics and food additives .

HY-Y0932

Isophorone	Structural Classification Animals Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Disease Research Fields Source Classification	Environmental Pollutants
Isophorone, an α,β-unsaturated cyclic ketone, is used as a precursor to polymers .

HY-N10391

(-)-Cleistenolide Cleistenolide	Infection Classification of Application Fields Ketones, Aldehydes, Acids Plants Annonaceae Disease Research Fields Cleistochlamys kirkii Oliver Cancer Source Classification	Bacterial
(-)-Cleistenolide is a α,β-unsaturated δ-lactone isolated from Cleistochlamys kirkii Oliver. (-)-Cleistenolide has antibacterial and antitumor activity .

HY-Y0932R

Isophorone (Standard)	Structural Classification Animals Ketones, Aldehydes, Acids Source Classification	Biochemical Assay Reagents Reference Standards
Isophorone (Standard) is the analytical standard of Isophorone. This product is intended for research and analytical applications. Isophorone, an α,β-unsaturated cyclic ketone, is used as a precursor to polymers .

HY-N16010

4-HNE-Dimethylacetal	Lipid	Biochemical Assay Reagents
4-HNE-Dimethylacetal is an α,β-unsaturated hydroxyalkenal that can be produced by lipid peroxidation in cells. 4-HNE-Dimethylacetal can be studied in research on cell signal transduction including pathways from cell cycle events to cellular adhesion .

HY-N7860

Δ2-cis Eicosenoic acid	Animals Ketones, Aldehydes, Acids Source Classification	Others
Δ2-cis Eicosenoic acid is an α,β-unsaturated fatty acid that has been extracted from fresh water clams and purified. A related compound, 2-octadecenoic acid, has been shown to improve liver function and decrease blood sugar in streptozocin-induced diabetic rats. Δ2-cis Eicosenoic acid and its salts have potential medicinal use for treating diabetes and improving lipid metabolism.

HY-Y0191R

α-Pyridone (Standard) 2-Pyridone (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Bacterial
α-Pyridone (Standard) is the analytical standard of α-Pyridone. This product is intended for research and analytical applications. α-Pyridone (2-Pyridone) is an antibacterial agent. α-Pyridone can be synthesized via the 1,4-addition of 2-(phenylsulfinyl)acetamide to α,β-unsaturated ketones followed by cyclization and sulfoxide elimination. α-Pyridone can also be used to synthesize a wide range of heterocyclic compounds .

HY-113466R

4-Hydroxynonenal (Standard) 4-HNE (Standard)	Structural Classification Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite	Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite Reference Standards
4-Hydroxynonenal (Standard) is the analytical standard of 4-Hydroxynonenal. This product is intended for research and analytical applications. 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria .

HY-W012346

Geranyl isobutyrate	Structural Classification Natural Products Animals Source Classification	Drug Derivative Bacterial
Geranyl isobutyrate is a synthetic α,β‑unsaturated branched‑chain aliphatic ester and a geraniol derivative. Geranyl isobutyrate acts as a food and feed flavouring agent and a biologically active antimicrobial compound. Geranyl isobutyrate shows antimicrobial activity against Gram‑positive and most Gram‑negative bacteria .

HY-N16821

Hydroxydihydrobovolide	Structural Classification Terpenoids Sesquiterpenes Myrtaceae Rhodomyrtus tomentosa Plants Source Classification	HIV
Hydroxydihydrobovolide is a α-β-unsaturatedγ-lactone found in Portulaca oleracea L.. Hydroxydihydrobovolide shows cytotoxicity against cancer cells and shows anti-HIV-1 activity (IC₅₀ = 122.7 μM). Hydroxydihydrobovolide can be used for the researches of neuroblastoma and HIV-1 infection .

HY-W697750

trans-2-Methyl-2-butenal Tiglaldehyde	Structural Classification Natural Products Allium schoenoprasum L. Plants Amaryllidaceae Source Classification	Biochemical Assay Reagents
trans-2-Methyl-2-butenal (Tiglaldehyde) is an adduct former that can be found in cigarette smoke, and very weakly inhibits growth of cancer cells and normal mouse cells. trans-2-Methyl-2-butenal forms adducts with glutathione (GSH) via Michael addition.trans-2-Methyl-2-butenal is an α,β-unsaturated carbonyl compound .

Cat. No.	Product Name	Chemical Structure

HY-113466S

4-Hydroxynonenal-d3
4-Hydroxynonenal-d₃ is the deuterium labeled 4-Hydroxynonenal. 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria .

4-Hydroxynonenal-d3

4-Hydroxynonenal-d₃ is the deuterium labeled 4-Hydroxynonenal. 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria .

HY-Y0932S

Isophorone-d5
Isophorone-d₅ is the deuterium labeled Isophorone. Isophorone, an α,β-unsaturated cyclic ketone, is used as a precursor to polymers .

HY-Y0932S1

Isophorone-d8
Isophorone-d₈ is the deuterium labeled Isophorone . Isophorone, an α,β-unsaturated cyclic ketone, is used as a precursor to polymers .

HY-Y0191S

α-Pyridone-d5
α-Pyridone-d₅ (2-Pyridone-d₅) is the deuterium labeled α-Pyridone (HY-Y0191). α-Pyridone (2-Pyridone) is an antibacterial agent. α-Pyridone can be synthesized via the 1,4-addition of 2-(phenylsulfinyl)acetamide to α,β-unsaturated ketones followed by cyclization and sulfoxide elimination. α-Pyridone can also be used to synthesize a wide range of heterocyclic compounds .

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α,β-unsaturated

Inhibitors & Agonists

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Isotope-Labeled Compounds

Natural
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