75899-68-2
75899-68-2
Chemical Structure
4-Hydroxynonenal
Synonym(s): 4-HNE
- CAS No.: 75899-68-2
- Formula:C9H16O2
- Molecular Weight:156.22
IUPAC Name: (E)-4-hydroxynon-2-enal
InChIKey: JVJFIQYAHPMBBX-FNORWQNLSA-N
SMILES: CCCCCC(O)/C=C/C=O
Biological Activity: 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4-Hydroxynonenal | 99.75% | 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria. | ||||||||||||||||||||
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4-Hydroxynonenal (Standard) | 99.52% | 4-Hydroxynonenal (Standard) is the analytical standard of 4-Hydroxynonenal. This product is intended for research and analytical applications. 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria. | ||||||||||||||||||||
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4-Hydroxynonenal-d3 | 99.0% | 4-Hydroxynonenal-d3 is the deuterium labeled 4-Hydroxynonenal. 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria. | ||||||||||||||||||||
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2-Octenal | 2-Octenal is an unsaturated aldehyde commonly found in essential oils of various plants, especially citrus fruits. 2-Octenal has unique chemical properties that make it an important ingredient in many applications where a strong, sweet and fruity aroma is desired. It is commonly used as a flavoring agent in food and beverages, and as a fragrance in perfumes, soaps, and cosmetics. | |||||||||||||||||||||
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4-Hydroxynonenal alkyne | 99.9% | 4-Hydroxynonenal alkyne (4-HNE alkyne) is a click chemical reagent containing alkynes. 4-Hydroxynonenal alkyne induces heme oxygenase and cell apoptosis in colon cancer (RKO) cells. | ||||||||||||||||||||
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(E)-4-Oxo-2-nonenal | 95.0% | (E)-4-Oxo-2-nonenal (4-ONE) is one of the major hemolytic decomposition products of lipid hydroperoxides. (E)-4-Oxo-2-nonenal is a major product of the FeII-mediated breakdown of lipid hydroperoxides. (E)-4-Oxo-2-nonenal is a potent transient receptor potential ankyrin 1 (TRPA1) agonist. | ||||||||||||||||||||
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(E)-4-Oxo-2-nonenal-d3 | (E)-4-Oxo-2-nonenal-d3 is the deuterium labeled (E)-4-Oxo-2-nonenal. | |||||||||||||||||||||
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(2E)-4-Hydroperoxy-2-nonenal | (2E)-4-Hydroperoxy-2-nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids, and can be used as a marker of oxidative stress. | |||||||||||||||||||||
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4-Hydroxy hexenal | 99.86% | 4-Hydroxy hexenal (4-HHE) is a lipid peroxidation product derived from oxidized ω-3 fatty acids such as DHA. | ||||||||||||||||||||
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4-Hydroxy hexenal-d3 | 4-Hydroxy hexenal-d3 is the deuterium labeled 4-Hydroxy hexenal. | |||||||||||||||||||||
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Octanoic acid-d3 | 99.1% | Octanoic acid-d3 is the deuterium labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes. | ||||||||||||||||||||
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2-Hydroxyhexanoic acid-d3 | 2-Hydroxyhexanoic acid-d3 is the d3 labeled 2-Hydroxyhexanoic acid (HY-75954). 2-Hydroxyhexanoic acid is a metabolite. 2-Hydroxyhexanoic acid is elevated in metastatic pancreatic neuroendocrine tumors. 2-Hydroxyhexanoic acid does not promote the proliferation, migration or invasion of pancreatic neuroendocrine tumor cells. 2-Hydroxyhexanoic acid can be used in the research of metastatic pancreatic neuroendocrine tumors. | |||||||||||||||||||||
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trans-4-Hydroxy-2-nonenoic acid | 99.78% | trans-4-Hydroxy-2-nonenoic acid (compound 4) is a nature product that could be isolated from the genus Pottsia. | ||||||||||||||||||||
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trans,trans-2,4-Decadienal-d4 | trans,trans-2,4-Decadienal-d4 is deuterated labeled trans,trans-2,4-Decadienal (HY-W013627). trans,trans-2,4-Decadienal is a lipid peroxidation product of linolieic acid. | |||||||||||||||||||||
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trans-2-Nonenal (Standard) | 99.34% | trans-2-Nonenal (Standard) is the analytical standard of trans-2-Nonenal. This product is intended for research and analytical applications. trans-2-Nonenal is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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(E)-2-Octenal | 99.29% | (E)-2-Octenal is an Antifungal agent. (E)-2-Octenal disrupts cell membrane integrity and causes ROS accumulation. (E)-2-Octenal decreases the activities of phosphofructokinase and pyruvate kinase. (E)-2-Octenal inhibits Neofusicoccum parvum growth by disrupting mitochondrial energy metabolism. (E)-2-Octenal suppresses the growth of a Prochloraz (HY-B0845)-resistant Penicillium italicum strain. (E)-2-octenal exerts a broad-spectrum and potent inhibitory effect on various fungi, including Sclerotium rolfsii, Metarhizium anisopliae sensu lato, and Aspergillus flavus, etc. (E)-2-Octenal can be used for the research of citrus blue mold and mango stem-end rot. | ||||||||||||||||||||
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(3R)-1-Octen-3-ol | (3R)-1-Octen-3-ol is an 8-carbon secondary alcohol and an off-flavor compound in soybean products. | |||||||||||||||||||||
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References
- [1]. Zhong H, et al. Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria. Redox Biol. 2015;4:193-9. [Content Brief]
- [2]. Csala M, et al. On the role of 4-hydroxynonenal in health and disease. Biochim Biophys Acta. 2015 May;1852(5):826-38. [Content Brief]
- [3]. Bhowmick S, et al. Traumatic brain injury-induced downregulation of Nrf2 activates inflammatory response and apoptotic cell death. J Mol Med (Berl). 2019 Nov 22. [Content Brief]
