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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
40 Results for "
α2δ
" in MedChemExpress (MCE) Product Catalog:
Products (40)
40 Results for "α2δ" in MCE Product Catalog:
9
9 Publications Verification
Synonyms: (S)-2-Amino-3-phenylpropionic acid
6
Target:
Research Areas:
Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS.
6
6 Cited Publications
Synonyms: DS 5565 besylate
Target:
Research Areas:
Mirogabalin besylate is a selective and orally available ligand for the α2δ subunit of voltage-gated calcium channels, with Kds of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively.
2
2 Cited Publications
Cat. No.: HY-N0215S10
CAS No.: 439685-11-7
Synonyms: (S)-2-Amino-3-phenylpropionic acid-13C9
1
1 Cited Publications
Cat. No.: HY-N0215S12
CAS No.: 56253-90-8
Synonyms: (S)-2-Amino-3-phenylpropionic acid-d5
1
1 Cited Publications
Cat. No.: HY-N0215S1
CAS No.: 17942-32-4
Synonyms: (S)-2-Amino-3-phenylpropionic acid-d8
1
1 Cited Publications
Cat. No.: HY-N0215S8
CAS No.: 180268-82-0
Synonyms: (S)-2-Amino-3-phenylpropionic acid-13C6
1
1 Cited Publications
Cat. No.: HY-N0215S7
CAS No.: 136056-02-5
Synonyms: (S)-2-Amino-3-phenylpropionic acid-3-13C
1
1 Cited Publications
Cat. No.: HY-N0215S2
CAS No.: 81201-86-7
Synonyms: (S)-2-Amino-3-phenylpropionic acid-13C
Cat. No.: HY-142240
CAS No.: 2209104-84-5
Synonyms: HSK16149
Target:
Research Areas:
Crisugabalin is an orally active, selective ligand for the α2δ subunit of voltage-gated calcium channels, with a target IC50 of 3.96 nM in rats. Crisugabalin inhibits the binding of [ 3H]gabapentin to the α2δ subunit, reduces calcium influx, decreases neuronal excitability, and impairs nociceptive transmission. Crisugabalin alleviates mechanical allodynia, neuropathic pain and inflammatory pain in rats, and reduces phase II pain behaviors. Crisugabalin can be used in research related to chronic pain, neuropathic pain, diabetic neuropathy, fibromyalgia, inflammatory pain, diabetic peripheral neuropathy and postherpetic neuralgia.
Cat. No.: HY-N0215S5
CAS No.: 29700-34-3
Synonyms: (S)-2-Amino-3-phenylpropionic acid-15N
Cat. No.: HY-N0215S11
CAS No.: 878339-23-2
Synonyms: (S)-2-Amino-3-phenylpropionic acid-13C9,15N
Cat. No.: HY-N0215S3
CAS No.: 221346-31-2
Synonyms: (S)-2-Amino-3-phenylpropionic acid-d2
Cat. No.: HY-12650S1
Synonyms: DS5565-d4
Cat. No.: HY-U00388
CAS No.: 313653-15-5
Target:
Research Areas:
α2δ ligand 1 is a ligand to the α2δ-1 subunit of voltage-sensitive calcium channel, extracted from patent US20040186177.
Cat. No.: HY-148866
CAS No.: 2143584-82-9
Target:
Research Areas:
Cavα2δ1&NET-IN-3 (example 216) is an inhibitor of the subunit α2δ of voltage-gated calcium channels (VGCC) and noradrenaline transporter (NET). Cavα2δ1&NET-IN-3 has Kis of 100-500 nM for human α2δ-1 subunit of Cav2.2 calcium channel and NET, respectively .
Cat. No.: HY-N0215S14
Synonyms: (S)-2-Amino-3-phenylpropionic acid-15N,d8
Cat. No.: HY-P3431
CAS No.: 2279952-25-7
Target:
Research Areas:
Cat. No.: HY-148863
CAS No.: 2143586-17-6
Target:
Research Areas:
Cavα2δ1&NET-IN-2 (Compound 45CS) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-2 inhibits Cavα2δ-1 with a Ki of 454 nM. Cavα2δ1&NET-IN-2 inhibits NET with a Ki of 59 nM and IC50 of 7 nM. Cavα2δ1&NET-IN-2 can be used for research of pain .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
