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Results for "

β-catenin modulator

" in MedChemExpress (MCE) Product Catalog:

By Targets:	β-catenin (19) Amyloid-β (1) Apoptosis (5) Autophagy (1) Bcl-2 Family (1) Beclin1 (1) Beta-secretase (1) Caspase (1) CaSR (1) CDK (2) Endogenous Metabolite (1) Epigenetic Reader Domain (1) Glucocorticoid Receptor (4) GSK-3 (1) Interleukin Related (1) JAK (1) JNK (2) Lipoxygenase (1) MMP (1) mTOR (1) p38 MAPK (1) Phosphodiesterase (PDE) (4) PI3K (1) PPAR (1) Reactive Oxygen Species (ROS) (2) Reference Standards (2) STAT (2) TGF-beta/Smad (1) TNF Receptor (1) Wnt (12)
By Research Areas:	Cancer (15) Cardiovascular Disease (1) Endocrinology (4) Inflammation/Immunology (7) Neurological Disease (5)

By Targets:

β-catenin (19)

Amyloid-β (1)

Apoptosis (5)

Autophagy (1)

Bcl-2 Family (1)

Beclin1 (1)

Beta-secretase (1)

Caspase (1)

CaSR (1)

CDK (2)

Endogenous Metabolite (1)

Epigenetic Reader Domain (1)

Glucocorticoid Receptor (4)

GSK-3 (1)

Interleukin Related (1)

JAK (1)

JNK (2)

Lipoxygenase (1)

MMP (1)

mTOR (1)

p38 MAPK (1)

Phosphodiesterase (PDE) (4)

PI3K (1)

PPAR (1)

Reactive Oxygen Species (ROS) (2)

Reference Standards (2)

STAT (2)

TGF-beta/Smad (1)

TNF Receptor (1)

Wnt (12)

By Research Areas:

Cancer (15)

Cardiovascular Disease (1)

Endocrinology (4)

Inflammation/Immunology (7)

Neurological Disease (5)

Inhibitors & Agonists

Peptides

MCE Kits

Natural
Products

Targets Recommended: β-catenin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14930

Mirodenafil SK3530	Phosphodiesterase (PDE) Glucocorticoid Receptor Wnt β-catenin Apoptosis	Neurological Disease Inflammation/Immunology Endocrinology
Mirodenafil (SK3530) is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil is a glucocorticoid receptor (GR) modulator Mirodenafil activates the *Wnt/β-catenin* signaling pathway by downregulating Dkk1 expression. Mirodenafil can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc) .

HY-111386

E-7386	Epigenetic Reader Domain	Cancer
E-7386 is an orally active *CBP/beta-catenin* modulator.

HY-14930A

Mirodenafil dihydrochloride SK-3530 dihydrochloride	Phosphodiesterase (PDE) Glucocorticoid Receptor Wnt β-catenin Apoptosis	Neurological Disease Inflammation/Immunology Endocrinology
Mirodenafil (SK3530) dihydrochloride is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil dihydrochloride is a glucocorticoid receptor (GR) modulator Mirodenafil dihydrochloride activates the *Wnt/β-catenin* signaling pathway by downregulating Dkk1 expression. Mirodenafil dihydrochloride can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc) .

HY-N0899

Wilforine	JAK STAT Wnt β-catenin	Inflammation/Immunology Cancer
Wilforine is an orally active JAK-STAT pathway inhibitor with immunomodulatory effects and the ability to inhibit osteoclast fusion. Wilforine disrupts lipid raft integrity, reprograms cholesterol and glycosphingolipid metabolic pathways, regulates NF-κB and the complement system, and modulates the expression of various interleukins. Wilforine also inhibits the *Wnt11/β-catenin* signaling pathway and suppresses the proliferation of fibroblast-like synoviocytes. Wilforine can serve as a quality and pharmacokinetic marker for Tripterygium glycoside tablets, and can be applied to research on related diseases such as rheumatoid arthritis, inflammatory osteolysis, and SAPHO syndrome .

HY-12557

γ-Glutamylvaline γ-Glu-Val	Endogenous Metabolite CaSR Wnt TNF Receptor Interleukin Related PPAR β-catenin	Inflammation/Immunology
γ‑Glutamylvaline (γ-Glu-Val) is a calcium‑sensing receptor (CaSR) agonist. γ‑Glutamylvaline activates CaSR and facilitates its binding to β‑arrestin 2 to modulate inflammatory and metabolic homeostasis signaling. γ‑Glutamylvaline inhibits TNF‑α‑induced IL‑6/MCP‑1 and enhances adiponectin/PPARγ in adipocytes. γ‑Glutamylvaline upregulates Wnt5a, restores *β‑catenin* phosphorylation, and reduces serine‑phosphorylated IRS‑1 in adipocytes. γ-Glutamylvaline can be used for the research of low-grade chronic inflammation .

HY-116553

FzM1	Wnt β-catenin	Cancer
FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC_50inh=?6.2). FzM1 binds to an allosteric binding site located in intracellular loop 3 (ICL3) of FZD4 and alters the conformation of the receptor, ultimately inhibiting the *WNT/β-catenin* cascade .

HY-169126

β-catenin modulator IIa-661	β-catenin Wnt	Cancer
β-catenin modulator IIa-661 is a *β-catenin* modulator that modulates β-catenin activity and inhibits the activity of the Wnt/wingless (wg) signaling pathway. β-catenin modulator IIa-661 can be utilized in cancer research .

HY-163896

β-Catenin modulator-7	β-catenin	Cancer
β-Catenin modulator-7 (Compound 5) is a modulator for *β-catenin. β-Catenin* modulator-7 inhibits the expression of β-catenin in HCT-116 cytoplasm and nucleus, suppresses the phosphorylation of GSK 3β. β-Catenin modulator-7 promotes NO release in HCT-116, and inhibits the proliferation of cancer cell HCT-116 with IC₅₀ of 0.6-0.9 μM. β-Catenin modulator-7 can be used in reasearch about colon cancer .

HY-169569

β-Catenin modulator-8	β-catenin	Cancer
β-Catenin modulator-8 (Compound Ⅸa) is a *β-Catenin* modulator and can be used for cancer research .

HY-153678

β-Catenin modulator-1	β-catenin	Cancer
β-Catenin modulator-1 (IIa-650) is a β-Catenin modulator useful in cancer research .

HY-153679

β-Catenin modulator-2	β-catenin	Cancer
β-Catenin modulator-2 (compound IIa-130), an oxazole and thiazole compound, is a potent and selective β-Catenin modulator .

HY-153682

β-Catenin modulator-5	β-catenin	Cancer
β-Catenin modulator-5 (compound IIa-84), an oxazole and thiazole compound, is a potent and selective β-Catenin modulator .

HY-153680

β-Catenin modulator-3	β-catenin	Cancer
β-Catenin modulator-3 (compound IIa-112), an oxazole and thiazole compound, is a potent and selective β-Catenin modulator .

HY-153681

β-Catenin modulator-4	β-catenin	Cancer
β-Catenin modulator-4 (compound IIa-92), an oxazole and thiazole compound, is a potent and selective β-Catenin modulator .

HY-185413

β-Catenin modulator-9	β-catenin Wnt	Cancer
β-Catenin modulator-9 (Compound IIa-2075) is a *β-Catenin* modulator. β-Catenin modulator-9 specifically targets the activity of the stable β-catenin pool and inhibits the Wnt signaling pathway. β-Catenin modulator-9 can be used in cancer-related research .

HY-138979

Lipoxygenin	Lipoxygenase	Others
Lipoxygenin is a non-redox 5-lipoxygenase (5-LO) inhibitor with an IC₅₀ of 5 μM. Lipoxygenin modulates the β-catenin-5-LO complex, inducing a decrease in β-catenin and 5-LO levels in the nucleus .

HY-49597

Pin1 modulator 1	Wnt β-catenin	Cancer
Pin1 modulator 1 (compound IIb-219) is a modulator that specifically targets *β-Catenin* and inhibits the Wnt pathway. Pin1 modulator 1 can be used in the study of Wnt-mediated related diseases, such as cancer .

HY-N2199

Sotetsuflavone	Apoptosis Autophagy PI3K JNK mTOR p38 MAPK CDK MMP TGF-beta/Smad STAT β-catenin Reactive Oxygen Species (ROS) Bcl-2 Family Caspase	Inflammation/Immunology Cancer
Sotetsuflavone is a flavonoid that can be isolated from Cycas revolute. Sotetsuflavone inhibits phosphorylation of PI3K, Akt, mTOR, JNK, and p38 MAPK; modulates expression of Cyclin D1, CDK4, Bcl-2, Bax, cleaved caspases 3/9, MMP-9, TGF-β, STAT3, and *β-catenin. Sotetsuflavone induces G₀/G₁ cell cycle arrest, apoptosis, autophagy, and intracellular ROS* elevation, inhibits cancer cell proliferation. Sotetsuflavone inhibits tumor growth in mouse tumor xenograft models. Sotetsuflavone can be used for the research of non-small cell lung cancer and Crohn’s disease .

HY-14930R

Mirodenafil (Standard) SK3530 (Standard)	Phosphodiesterase (PDE) Glucocorticoid Receptor Wnt β-catenin Apoptosis Reference Standards	Neurological Disease Inflammation/Immunology Endocrinology
Mirodenafil (Standard) is the analytical standard of Mirodenafil. This product is intended for research and analytical applications. Mirodenafil (SK3530) is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil is a glucocorticoid receptor (GR) modulator Mirodenafil activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc) .

HY-181160

*JNK3/Wnt/β-catenin* modulator-1**	JNK Wnt β-catenin Amyloid-β Reactive Oxygen Species (ROS) Beclin1 GSK-3 Beta-secretase	Neurological Disease
JNK3/Wnt/β-catenin modulator-1 is a brain-penetrant JNK3 inhibitor and *Wnt/β-catenin* activator. JNK3/Wnt/β-catenin modulator-1 decreases Aβ_1-42 production and reduced ROS generation. JNK3/Wnt/β-catenin modulator-1 inhibits the activation of JNK and Puma, promotes Beclin-1 expression, reduces GSK-3β and BACE1 expression and activates Wnt/β-catenin signaling. JNK3/Wnt/β-catenin modulator-1 improves cognitive and memory performance, attenuates histopathological brain damage, preserves structure of hippocampal pyramidal cells and cerebral cortical neurons. JNK3/Wnt/β-catenin modulator-1 can be used for the research of Alzheimer's disease .

HY-14930AR

Mirodenafil dihydrochloride (Standard) SK-3530 dihydrochloride (Standard)	Phosphodiesterase (PDE) Glucocorticoid Receptor Wnt β-catenin Apoptosis Reference Standards	Neurological Disease Inflammation/Immunology Endocrinology
Mirodenafil (dihydrochloride) (Standard) is the analytical standard of Mirodenafil (dihydrochloride). This product is intended for research and analytical applications. Mirodenafil (SK3530) dihydrochloride is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil dihydrochloride is a glucocorticoid receptor (GR) modulator Mirodenafil dihydrochloride activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil dihydrochloride can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc) .

HY-E70690

CDK8/CycC Recombinant Human Active Protein Kinase	CDK	Cancer
CDK8 modulates the transcriptional output from distinct transcription factors involved in oncogenic control, including the Wnt/β-catenin pathway, Notch, p53, and transforming growth factor β. Abnormal activity ofCDK8 along with its partner protein cyclin C (CycC) is a common feature of many diseases including colorectal cancer. CDK8/CycC Recombinant Human Active Protein Kinase can be used to study the function of CDK8/CycC .

HY-115474

Cardionogen-2	Wnt	Cardiovascular Disease
Cardionogen-2 is a biphasic modulator of cardiogenesis, either promoting or inhibiting heart formation depending on the stage of treatment. Cardionogen-2 inhibits *Wnt/β-catenin*-dependent transcription in murine embryonic stem (ES) cells and zebrafish embryos .

Cat. No.	Product Name	Target	Research Area

HY-12557

γ-Glutamylvaline γ-Glu-Val	Endogenous Metabolite CaSR Wnt TNF Receptor Interleukin Related PPAR β-catenin	Inflammation/Immunology
γ‑Glutamylvaline (γ-Glu-Val) is a calcium‑sensing receptor (CaSR) agonist. γ‑Glutamylvaline activates CaSR and facilitates its binding to β‑arrestin 2 to modulate inflammatory and metabolic homeostasis signaling. γ‑Glutamylvaline inhibits TNF‑α‑induced IL‑6/MCP‑1 and enhances adiponectin/PPARγ in adipocytes. γ‑Glutamylvaline upregulates Wnt5a, restores *β‑catenin* phosphorylation, and reduces serine‑phosphorylated IRS‑1 in adipocytes. γ-Glutamylvaline can be used for the research of low-grade chronic inflammation .

Human iPSC/ESC Cardiomyocyte Induction Differentiation Kit
MCE Human iPSC/ESC Cardiomyocyte Induction Differentiation Kit is based on the classical GiWi system. By precisely modulating the Wnt/β-catenin signaling pathway in a temporally controlled manner (sequential activation and inhibition), the kit enables highly efficient directed differentiation of human pluripotent stem cells into cardiomyocytes. It is suitable for cardiac disease modeling, drug cardiotoxicity assessment, and mechanistic studies.

Wilforine	Cardiovascular Disease Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Celastraceae Tripterygium wilfordii Hook. f. Plants Disease Research Fields Source Classification	JAK STAT Wnt β-catenin
Wilforine is an orally active JAK-STAT pathway inhibitor with immunomodulatory effects and the ability to inhibit osteoclast fusion. Wilforine disrupts lipid raft integrity, reprograms cholesterol and glycosphingolipid metabolic pathways, regulates NF-κB and the complement system, and modulates the expression of various interleukins. Wilforine also inhibits the *Wnt11/β-catenin* signaling pathway and suppresses the proliferation of fibroblast-like synoviocytes. Wilforine can serve as a quality and pharmacokinetic marker for Tripterygium glycoside tablets, and can be applied to research on related diseases such as rheumatoid arthritis, inflammatory osteolysis, and SAPHO syndrome .

Sotetsuflavone	Structural Classification Flavonoids Classification of Application Fields Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Source Classification Cancer	Apoptosis Autophagy PI3K JNK mTOR p38 MAPK CDK MMP TGF-beta/Smad STAT β-catenin Reactive Oxygen Species (ROS) Bcl-2 Family Caspase
Sotetsuflavone is a flavonoid that can be isolated from Cycas revolute. Sotetsuflavone inhibits phosphorylation of PI3K, Akt, mTOR, JNK, and p38 MAPK; modulates expression of Cyclin D1, CDK4, Bcl-2, Bax, cleaved caspases 3/9, MMP-9, TGF-β, STAT3, and *β-catenin. Sotetsuflavone induces G₀/G₁ cell cycle arrest, apoptosis, autophagy, and intracellular ROS* elevation, inhibits cancer cell proliferation. Sotetsuflavone inhibits tumor growth in mouse tumor xenograft models. Sotetsuflavone can be used for the research of non-small cell lung cancer and Crohn’s disease .

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