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Cat. No.: HY-163896

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β-Catenin modulator-7

β-Catenin modulator-7 (Compound 5) is a modulator for β-catenin. β-Catenin modulator-7 inhibits the expression of β-catenin in HCT-116 cytoplasm and nucleus, suppresses the phosphorylation of GSK 3β. β-Catenin modulator-7 promotes NO release in HCT-116, and inhibits the proliferation of cancer cell HCT-116 with IC₅₀ of 0.6-0.9 μM. β-Catenin modulator-7 can be used in reasearch about colon cancer.

For research use only. We do not sell to patients.

CAS No.: 2892294-93-6
Formula: C₂₆H₃₅ClN₄O₉
Molecular Weight:583.03

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

β-Catenin modulator-7 Chemical Structure

CAS No.: 2892294-93-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.6 μM Compound: 5	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 39045852]
A549	IC₅₀	0.8 μM Compound: 5	Antiproliferative activity against human A549 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 24 hrs by MTT assay	[PMID: 39045852]
CCD-841CoN	IC₅₀	11.3 μM Compound: 5	Cytotoxicity against human CCD-841CoN cells incubated for 24 hrs by MTT assay Cytotoxicity against human CCD-841CoN cells incubated for 24 hrs by MTT assay	[PMID: 39045852]
CCD-841CoN	IC₅₀	6.1 μM Compound: 5	Cytotoxicity against human CCD-841CoN cells incubated for 72 hrs by MTT assay Cytotoxicity against human CCD-841CoN cells incubated for 72 hrs by MTT assay	[PMID: 39045852]
HCT-116	IC₅₀	0.6 μM Compound: 5	Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by MTT assay	[PMID: 39045852]
HCT-116	IC₅₀	0.9 μM Compound: 5	Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by MTT assay	[PMID: 39045852]

Chemical Information

CAS No. 2892294-93-6
Molecular Weight 583.03
Formula C₂₆H₃₅ClN₄O₉
SMILES

[O-]/[N+](N(CC)CC)=N\OCOC(CCCCOC1=C(OC)C=C(/C=C/C(N(CCC=C2Cl)C2=O)=O)C=C1OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zou Y, et al., Discovery of Cytotoxic Nitric Oxide-Releasing Piperlongumine Derivatives Targeting Wnt/β-Catenin in Colon Cancer Cells. J Nat Prod. 2024 Jul 24. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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